Smoking, blood DNA methylation sites and lung cancer risk

Domingo‐Relloso, Arce; Joehanes, Roby; Rodriguez-Hernandez, Zulema; Lahousse, Lies; Haack, Karin; Fallin, M. Daniele; Herreros-Martinez, Miguel; Umans, Jason G.; Best, Lyle G.; Huan, Tianxiao; Liu, Chunyu; Ma, Jiantao; Yao, Chen; Jérolon, Allan; Bermúdez, José D.; Cole, Shelley A.; Rhoades, Dorothy A.; Levy, Daniel; Navas‐Acien, Ana; Téllez-Plaza, María

doi:10.1016/j.envpol.2023.122153

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Although tobacco smoking is widely recognized as a harmful behaviour with significant impacts on human health, smoking or exposure to smoke continues to be prevalent worldwide. Tobacco smoking is a risk factor for and is a frequent cause of many adverse health consequences, such as chronic obstructive pulmonary disease (COPD) [ 1 ], cardiovascular diseases [ 2 ], asthma [ 3 ] and various forms of cancer, in particular lung cancer [ 4 , 5 ]. Moreover, smoking status appears to contribute to a poor prognosis in COVID-19 patients [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Epigenetic mechanisms, specifically alterations in DNA methylation, have been suggested to moderate the impact of tobacco smoking, leading to changes in transcriptional activity and contributing to smoking-related diseases [ 9 ]. With the update of DNA methylation arrays, the impact of smoking on DNA 5-methylcytosine (5mC) methylation has been thoroughly investigated in blood cells from adults, revealing significant disparities between smokers and non-smokers [ 10 , 11 ], which can be even more conspicuous in specific tissues like vascular endothelial cells [ 12 ], and vulnerable groups like cancer patients [ 4 ]. The impact of tobacco smoking on DNA methylation is also prominent in the blood of newborns whose mothers smoked during pregnancy [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Smoking-Induced DNA Hydroxymethylation Signature Is Less Pronounced than True DNA Methylation: The Population-Based KORA Fit Cohort

Lai,

Matías-García,

Kretschmer

et al. 2024

Biomolecules

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Despite extensive research on 5-methylcytosine (5mC) in relation to smoking, there has been limited exploration into the interaction between smoking and 5-hydroxymethylcytosine (5hmC). In this study, total DNA methylation (5mC+5hmC), true DNA methylation (5mC) and hydroxymethylation (5hmC) levels were profiled utilizing conventional bisulphite (BS) and oxidative bisulphite (oxBS) treatment, measured with the Illumina Infinium MethylationEPIC BeadChip. An epigenome-wide association study (EWAS) of 5mC+5hmC methylation revealed a total of 38,575 differentially methylated positions (DMPs) and 2023 differentially methylated regions (DMRs) associated with current smoking, along with 82 DMPs and 76 DMRs associated with former smoking (FDR-adjusted p < 0.05). Additionally, a focused examination of 5mC identified 33 DMPs linked to current smoking and 1 DMP associated with former smoking (FDR-adjusted p < 0.05). In the 5hmC category, eight DMPs related to current smoking and two DMPs tied to former smoking were identified, each meeting a suggestive threshold (p < 1 × 10−5). The substantial number of recognized DMPs, including 5mC+5hmC (7069/38,575, 2/82), 5mC (0/33, 1/1), and 5hmC (2/8, 0/2), have not been previously reported. Our findings corroborated previously established methylation positions and revealed novel candidates linked to tobacco smoking. Moreover, the identification of hydroxymethylated CpG sites with suggestive links provides avenues for future research.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Smoking-Induced DNA Hydroxymethylation Signature Is Less Pronounced than True DNA Methylation: The Population-Based KORA Fit Cohort

Lai,

Matías-García,

Kretschmer

et al. 2024

Biomolecules

View full text Add to dashboard Cite

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Methods for the Analysis of Multiple Epigenomic Mediators in Environmental Epidemiology

Domingo-Relloso,

Tellez-Plaza,

Valeri

2024

Curr Envir Health Rpt

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Racial disparity in uterine leiomyoma: new insights of genetic and environmental burden in myometrial cells

Khan,

McNally,

Kim

et al. 2024

Molecular Human Reproduction

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Uterine leiomyoma (LM), also known as uterine fibroids, are common gynecological tumors and can reach a prevalence of 70% among women by the age of 50 years. Notably, the LM burden is much higher in Black women with earlier onset, a greater tumor number, size, and severity compared to White women. Published knowledge shows that there are genetic, environmental, and lifestyle-based risk factors associated with racial disparity for LM. Significant strides have been made on genomic, epigenomic, and transcriptomic data levels in Black and White women to elucidate the underlying pathomolecular reasons of racial disparity in LM development. However, racial disparity of LM remains a major area of concern in gynecological research. This review highlights risk factors of LM and their role in different races. Furthermore, we discuss the genetics and uterine myometrial microenvironment in LM development. Comparative findings revealed that a major racial difference in the disease is linked to myometrial oxidative burden and altered ROS pathways which is relevant to the oxidized guanine in genomic DNA and MED12 mutations that drive the LM genesis. Considering the burden and morbidity of LM, we anticipate that this review on genetic risk and myometrial microenvironment will strengthen understanding and propel the growth of research to address the racial disparity of LM burden.

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Smoking, blood DNA methylation sites and lung cancer risk

Cited by 3 publications

References 41 publications

Smoking-Induced DNA Hydroxymethylation Signature Is Less Pronounced than True DNA Methylation: The Population-Based KORA Fit Cohort

Smoking-Induced DNA Hydroxymethylation Signature Is Less Pronounced than True DNA Methylation: The Population-Based KORA Fit Cohort

Methods for the Analysis of Multiple Epigenomic Mediators in Environmental Epidemiology

Racial disparity in uterine leiomyoma: new insights of genetic and environmental burden in myometrial cells

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