Smoking behaviour and knowledge of the health effects of smoking in patients with inflammatory bowel disease

Bie, Charlotte de; Ballet, Vera; Hendriks, Niels; Coenen, Samuel; Weyts, Ellen; Assche, Gert Van; Vermeire, Séverine; Ferrante, Marc

doi:10.1111/apt.13423

Cited by 28 publications

(21 citation statements)

References 33 publications

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“…16,18 Studies in non-IBD populations have found that smoking initiation is more likely when there is a perceived short-term benefit, despite acceptance of short-and long-term risks. Furthermore, we found no evidence that smoking cessation impacts adversely on subsequent clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…18 Data from the Swiss IBD Cohort found that only 2.6% of smokers with UC received any support to cease smoking, suggesting clinicians may be hesitant to recommend smoking cessation to patients with UC. 18 Data from the Swiss IBD Cohort found that only 2.6% of smokers with UC received any support to cease smoking, suggesting clinicians may be hesitant to recommend smoking cessation to patients with UC.…”

Section: Findings In Relation To Previous Studiesmentioning

confidence: 99%

“…16 The wider health benefits of smoking cessation are beyond dispute 17 but its impact on clinical outcomes in UC is poorly understood. 18 One study found that four out of 19 ex-smokers with UC (21%) reported resuming smoking to prevent a flare of their disease. 3,5,11 One small study, following 32 patients who stopped smoking after being diagnosed with UC, reported that patients subsequently had more active disease, hospital admissions and use of corticosteroids and thiopurines compared with the period when they were actively smoking.…”

Section: Introductionmentioning

confidence: 99%

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The impact of smoking and smoking cessation on disease outcomes in ulcerative colitis: a nationwide population‐based study

Blackwell

Saxena

Alexakis

et al. 2019

Aliment Pharmacol Ther

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Background:Smokers are less likely to develop ulcerative colitis (UC) but the impact of smoking and subsequent cessation on clinical outcomes in UC is unclear. Aim:To evaluate the effect of smoking status and smoking cessation on disease outcomes.Methods: Using a nationally representative clinical research database, we identified incident cases of UC during 2005-2016. Patients were grouped as never-smokers, ex-smokers and smokers based on smoking status recorded in the 2 years preceding UC diagnosis. We defined subgroups of persistent smokers and smokers who quit within 2 years after diagnosis. We compared the rates of overall corticosteroid use, corticosteroid-requiring flares, corticosteroid dependency, thiopurine use, hospitalisation and colectomy between these groups. Results:We identified 6754 patients with a new diagnosis of UC over the study period with data on smoking status, of whom 878 were smokers at diagnosis. Smokers had a similar risk of corticosteroid-requiring flares (OR 1.16, 95% CI 0.92-1.25), thiopurine use (HR 0.84, 95% CI 0.62-1.14), corticosteroid dependency (HR 0.85, 95% CI 0.60-1.11), hospitalisation (HR 0.92, 95% CI 0.72-1.18) and colectomy (HR 0.78, 95% CI 0.50-1.21) in comparison with never-smokers. Rates of flares, thiopurine use, corticosteroid dependency, hospitalisation and colectomy were not significantly different between persistent smokers and those who quit smoking after a diagnosis of UC. Conclusions:Smokers and never-smokers with UC have similar outcomes with respect to flares, thiopurine use, corticosteroid dependency, hospitalisation and colectomy. Smoking cessation was not associated with worse disease course. The risks associated with smoking outweigh any benefits. UC patients should be counselled against smoking. | 557 BLACKWELL Et AL.

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Section: Discussionmentioning

confidence: 99%

Section: Findings In Relation To Previous Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The impact of smoking and smoking cessation on disease outcomes in ulcerative colitis: a nationwide population‐based study

Blackwell

Saxena

Alexakis

et al. 2019

Aliment Pharmacol Ther

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“…Prior studies demonstrated that only one-third to one-half of patients with Crohn's disease were aware that smoking could worsen their prognosis ( 17,18 ). Patients who were actively smoking were the least informed ( 17 ).…”

Section: Conflict Of Interestmentioning

confidence: 99%

Editorial: Smoking Cessation for Crohn’s Disease: Clearing the Haze

Kaplan

2016

American Journal of Gastroenterology

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The TABACROHN Study Group conducted a multicenter prospective cohort study, demonstrating that smoking cessation improved the prognosis of Crohn's disease. Patients who continued to smoke were 50% more likely to relapse compared with non-smokers. Smoking cessation reduced the risk of fl aring, regardless of exposure to anti-tumor necrosis factor agents. Despite the evidence that smoking cessation is benefi cial, many patients do not quit smoking after their diagnosis of Crohn's disease. Lack of awareness, physical addiction, and social context of smoking inhibit smoking cessation. In spite of this, comprehensive smoking cessation programs have been shown to be effective and reduce costs.

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“…1 The authors examined patient-awareness of the effects of smoking on the natural history of inflammatory bowel disease (IBD). The majority of IBD patients seemed unaware of the fact that smokers have an increased risk of developing Crohn's disease, an increased likelihood of requiring surgery, and higher rates of recurrence after surgery.…”

mentioning

confidence: 99%

Letter: smoking as a modifiable risk factor for a complicated course in Crohn's disease

Gracie

Ford

2016

Aliment Pharmacol Ther

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Smoking behaviour and knowledge of the health effects of smoking in patients with inflammatory bowel disease

Abstract: SUMMARY BackgroundThe detrimental effect of smoking on development and progression of Crohn's disease (CD) is generally accepted.

Cited by 28 publications

References 33 publications

The impact of smoking and smoking cessation on disease outcomes in ulcerative colitis: a nationwide population‐based study

The impact of smoking and smoking cessation on disease outcomes in ulcerative colitis: a nationwide population‐based study

Editorial: Smoking Cessation for Crohn’s Disease: Clearing the Haze

Letter: smoking as a modifiable risk factor for a complicated course in Crohn's disease

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