Smoking behavior in liver transplant recipients

Heide, Frans van der; Dijkstra, Gerard; Porte, Robert J.; Kleibeuker, Jan H.; Haagsma, Elizabeth B.

doi:10.1002/lt.21722

Cited by 75 publications

(41 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After de-duplication, 5644 articles were left for screening according to the titles and abstracts, with 78 records determined as potentially eligible. The full texts and data integrity of these studies were reviewed, and 8 articles and 3 additional articles retrieved through the references of the above were included in this meta-analysis (Fig 1)[2,3,5,20–27]. The characteristics of the included studies are presented in Table 5.…”

Section: Resultsmentioning

confidence: 99%

“…Pungpapong et al found that the incidence of vascular complications increased from 8% in non-smokers to 17.8% in smokers after liver transplantation[32]. Van der Heide et al also showed that hepatic artery thrombosis following liver transplantation occurred more frequently in smokers (15%) than nonsmokers (7%)[2]. However, considering the small number of smokers in whom vascular complications developed in these studies (i.e., 29 of 163 smokers in Pungpapong’s study and 9 in 59 smokers in Van del Heide’s study), these results could not be generalized.…”

Section: Discussionmentioning

confidence: 99%

“…And it remains a major public health problem in the 21 st century[1]. Tobacco use is quite prevalent among liver transplant patients, with a reported range of 14.7% to 75%[2–5]. However, the potential relevance of cigarette smoking to morbidity and mortality following liver transplantation is understudied.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of cigarette smoking on early complications after liver transplantation: A single-center experience and a meta-analysis

Li¹,

Wang²,

Ma³

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

BackgroundWhile studies have shown that cigarette smoking has negative implications on the long-term outcome following liver transplantation, its role in early complications is inconclusive.MethodsThe clinical data of 162 consecutive adult patients who underwent elective liver transplantation from January, 2012 to March, 2016 were analyzed. Patients were defined as active smokers, ex-smokers, or non-smokers on the basis of documentation at the time of liver transplantation. The overall complications following liver transplantation were expressed as the comprehensive complication index (CCI). The specific complications such as the incidence of hepatic artery thrombosis, biliary complications, acute kidney injury were also assessed. A meta-analysis was carried out based on results from the present study and 11 published studies.ResultsWe found that cigarette smoking was not associated with higher CCI scores and smokers did not have a higher risk for developing hepatic artery thrombosis, biliary complications, acute kidney injury after liver transplantation. Meta-analysis confirmed the null association between cigarette smoking and an increased incidence of hepatic artery thrombosis or biliary complications in liver transplant recipients. However, the pooled results showed a significantly higher risk of cardiovascular diseases and de-novo malignancies in smokers following liver transplantation.ConclusionThere is not enough evidence supporting an association between cigarette smoking and early mortality and morbidity after liver transplantation. However, smokers should still be encouraged to quit before and after liver transplantation due to the long-term health benefits of smoking cessation.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of cigarette smoking on early complications after liver transplantation: A single-center experience and a meta-analysis

Li¹,

Wang²,

Ma³

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Up to 60% of liver transplant candidates have a lifetime history of smoking and the prevalence in alcoholic liver disease is up to 70%(42). Smoking is considered to be responsible for morbidity and mortality after liver transplant, contributing to the increased incidence of cardiovascular disease and cancers in this group(21, 43).…”

Section: Special Issues In Patients With Alcoholic Liver Disease and mentioning

confidence: 99%

Management of Alcohol Use Disorder in Patients Requiring Liver Transplant

Lee

Leggio

2015

AJP

View full text Add to dashboard Cite

Alcoholic liver disease is the second most common indication for orthotopic liver transplantation in western countries. The majority of patients with alcoholic liver disease, however, are not referred for transplant evaluation. If evaluated, a 6 month period of sobriety is required before waitlisting for transplant. The consequences of relapse to alcohol use in patients on the waitlist are usually removal from the list. Therefore, identification and treatment of alcohol use disorder in patients with end-stage liver disease greatly impacts quality of life, treatment options and survival in patients’ course with this grave illness. Psychosocial and behavioral interventions prior to transplant appear to reduce drinking in the period before the surgery as well as reduce relapse rates post-transplant. Only one of the three medications approved by the Food and Drug Administration, acamprosate, seems feasible for use in patients with end-stage liver disease, while several other medications currently under investigation for the treatment of alcohol use disorder can be considered for use in this population. While only baclofen has been formally studied in alcoholic patients with end-stage liver disease with positive results for safety and efficacy, other medications also hold promise to treat alcohol use disorder in this population. Transplant programs with addictions specialists who function as an integral part of the treatment team may offer better outcomes to patients in terms of success of maintaining sobriety both pre- and post-transplant.

show abstract

“…17 Finally, active smoking was found in 16% of our patients, which appears to be similar to the recent report of Van der Heide. 18 Smokers are at risk for both de novo malignancies 19 and cardiovascular events. Ceasing smoking before undergoing a liver transplant is important and a challenge.…”

Section: Olivier Guillaud Et Al /Experimental and Clinical Transplantmentioning

confidence: 99%

Cardiovascular Risk 10 Years After Liver Transplant

Guillaud

Boillot²,

Sebbag³

et al. 2014

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: We sought to evaluate the frequency of cardiovascular risk factors in a cohort of patients 10 years after a liver transplant, and to assess their 10-year risk of fatal cardiovascular disease using Systematic COronary Risk Evaluation charts. Materials and Methods: Between January 1990 and June 1996, one hundred eighty-nine adults underwent a first liver transplant in our center. Fifty-nine patients (31%) died before reaching their tenth year, and 115 patients were available with complete clinical data at 10 years. Results: The main indications for liver transplant were alcoholic (38%) and viral cirrhosis (40%). The median age of patients was 56 (range, 29-73 y), 80% were men, 23% were obese, 16% were active smokers, 18% were diabetic, 40% had hypercholesterolemia, and 77% had hypertension. Before the 10th year after transplant, 6 deaths were because of cardiovascular diseases, which represents the third cause of late death (> 1 year after liver transplant). After liver transplant, 5% of the surviving patients underwent ischemic cardiovascular events during the first decade. At a 10-year assessment, the median estimated 10-year risk of fatal cardiovascular disease was 1% (range, 0%-9%) and 10% of the patients had a high risk (ie, SCORE ≥ 5%). Conclusions: Our results suggest that the frequency of cardiovascular events is relatively low after a liver transplant, even if most of the patients had 1 or more cardiovascular risk factors. Nevertheless, clinicians should perform a similar evaluation 15 or 20 years after the liver transplant because cardiovascular risk exponentially increases with age.

show abstract

Smoking behavior in liver transplant recipients

Cited by 75 publications

References 43 publications

Impact of cigarette smoking on early complications after liver transplantation: A single-center experience and a meta-analysis

Impact of cigarette smoking on early complications after liver transplantation: A single-center experience and a meta-analysis

Management of Alcohol Use Disorder in Patients Requiring Liver Transplant

Cardiovascular Risk 10 Years After Liver Transplant

Contact Info

Product

Resources

About