Smoking as an independent risk factor for severe skin reactions due to adjuvant radiotherapy for breast cancer

Sharp, Lena; Johansson, Hemming; Hatschek, Thomas; Bergenmar, Mia

doi:10.1016/j.breast.2013.07.047

Cited by 63 publications

(50 citation statements)

References 36 publications

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“…Yet for smoking, the habit has been associated with the occurrence of radiodermatitis before, 19,20 which was confirmed in this study. Chronic exposure to tobacco smoke causes changes in the physiology of many organ systems, including the skin.…”

Section: Discussionsupporting

confidence: 84%

“…25 In addition to the known relationship between smoking and the incidence of different types of cancer, this study demonstrates the pernicious role of this habit also in the occurrence of radiodermatitis, a major adverse effect of antineoplastic therapy that impacts on patient's quality of life. 13,15,16,20 CONCLUSION Two-thirds of the study patients had chronic radiodermatitis after 6 months of completion of radiotherapy for cancer treatment in the head and neck region. Smoking was associated with the occurrence of radiodermatitis in this group.…”

Section: Discussionmentioning

confidence: 93%

“…21 Smoking has been identified previously as a serious risk factor for skin reaction in patients undergoing radiotherapy for breast cancer. 20 The longer the smoking habit, the higher and more severe will be the skin reactions; and the concomitant application of radiotherapy makes the habit even more harmful for the skin. 19 It is important to highlight the high number of smokers found in this study population (86.8%).…”

Section: Discussionmentioning

confidence: 99%

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Smoking influences the Occurrence of Radiodermatitis in Head and Neck-irradiated Patients

Kuga¹,

Tonetto²,

Caetano³

et al. 2017

World Journal of Dentistry

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Smoking influences the Occurrence of Radiodermatitis in Head and Neck-irradiated Patients

Kuga¹,

Tonetto²,

Caetano³

et al. 2017

World Journal of Dentistry

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“…Non-smokers had lower skin toxicity scores (Wells et al 2004). Sharp et al (2013) examined risk factors for severe acute radiation skin reactions in women undergoing RT for breast cancer. Radiation dose and smoking were the factors most strongly related to severe acute skin reactions (Sharp et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Sharp et al (2013) examined risk factors for severe acute radiation skin reactions in women undergoing RT for breast cancer. Radiation dose and smoking were the factors most strongly related to severe acute skin reactions (Sharp et al 2013). Duffy et al (2002) who used a QOL questionnaire SF-36V (Ware et al, 1994) on 81 head and neck cancer patients found that smoking was negatively associated with physical and social functioning, general health, vitality, and role-emotional health.…”

Section: Discussionmentioning

confidence: 99%

Changes in health related quality of life in women and men undergoing radiation treatment for head and neck cancer and the impact of smoking status in the radiation treatment period

Egestad

Emaus

2014

European Journal of Oncology Nursing

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Abstract:Purpose The aim of this study was to evaluate health-related quality of life (HRQOL) in women and men undergoing radiation treatment for head and neck cancer through the intervention period and examine if age, body mass index (BMI) and smoking status at baseline may modify changes in HRQOL. Results Most aspects of HRQOL declined substantially and significantly (p<0.001) with a magnitude of more than one standard deviation during the radiation treatment period irrespective of sex and age. Smoking status at baseline had some, albeit minor, influence on changes in HRQOL. Patients who continued smoking during therapy had significantly higher decline in several aspects of HRQOL, compared to patients who stopped smoking.Conclusions HRQOL decline with substantial magnitude in patients undergoing radiation treatment for head and neck cancer, but smoking cessation may modify the declining quality of life. IntroductionTreatments of head and neck (H&N) cancer include surgery, radiotherapy (RT), chemotherapy, target therapy or a combination of these modalities. The diagnosis and the following treatment may exert a severe impact on patient's quality of life (QOL) (So et al., 2012). The malignancy affects the most visible area of the body, and may influence the most fundamental activities of daily life in a negative way, such as speech, breathing, eating and drinking (Larsson and Hedelin, 2003;Wells 1998). H&N cancer patients' illness often involves physical symptoms, psychological distress, as well as side effects from RT (Archer et al., 2008). The treatment can result in dry mouth (xerostomia), oral discomfort, mucositis, recurrent microbial infections, difficulty in chewing and swallowing, increased incidence of dental caries, impaired taste, and an inability to wear dentures (Parsons et al., 1994). In addition, depression is reported to increase in H&N cancer patients undergoing RT (Neilson et al., 2010;Kelly et al., 2007).The interest in health-related quality of life (HRQOL) (i.e. the physical, mental, and social functioning and well-being) in H&N cancer patients has increased over the two decades (So et al., 2012). Even if the most important outcome for cancer patients is overall survival, the disease and its treatment often have a major impact on HRQOL and functional status (List et al., 2002). Reliable and valid HRQOL questionnaires are available (Aaronson et al., 1993; Bjordal et al., 2000;Ringash and Bezjak, 2001). The EORTC QLQ-H&N35 is widely used to measure quality of life in H&N cancer patients (Singer et al., 2013). Both prospective and cross-sectional studies (Bjordal et al., 2001;Hammerlid et al., 2001aHammerlid et al., , 2001bHammerlid et al., , 2001cNguyen et al., 2002;Talmi et al., 2002;Shepherd and Fisher, 2004) have documented reductions in HRQOL in populations of H&N cancer patients who have received RT. Several studies have also examined changes in HRQOL during the treatment period (Bjordal et al., 2001;Henson et al., 2001; Airolldi et al., 2004;Parliament et al., 2004;Jabbari et al., 2...

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Acute and Late Skin Toxicity from Breast Radiation

Sloan

Alcorn

2019

Toxicities of Radiation Treatment for Breast Cancer

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Smoking as an independent risk factor for severe skin reactions due to adjuvant radiotherapy for breast cancer

Cited by 63 publications

References 36 publications

Smoking influences the Occurrence of Radiodermatitis in Head and Neck-irradiated Patients

Smoking influences the Occurrence of Radiodermatitis in Head and Neck-irradiated Patients

Changes in health related quality of life in women and men undergoing radiation treatment for head and neck cancer and the impact of smoking status in the radiation treatment period

Acute and Late Skin Toxicity from Breast Radiation

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