Smoking and the patency of lower extremity bypass grafts: A meta-analysis

Willigendael, Edith M.; Teijink, Joep A.W.; Bartelink, Marie-Louise; Peters, Ron J.G.; Büller, Harry R.; Prins, Martin H.

doi:10.1016/j.jvs.2005.03.024

Cited by 168 publications

(74 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Smoking independently increases the risk of graft failure by ≤4-fold. 33 It was recently shown that smokers with atherosclerotic diseases benefit more from antiplatelet therapy targeting the P2Y 12 -receptor than nonsmoking atherosclerotic patients. However, the mechanism remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Aberrant Circulating Levels of Purinergic Signaling Markers Are Associated With Several Key Aspects of Peripheral Atherosclerosis and Thrombosis

Jalkanen

Yegutkin

Hollmén

et al. 2015

Circulation Research

View full text Add to dashboard Cite

Rationale: Purinergic signaling plays an important role in inflammation and vascular integrity, but little is known about purinergic mechanisms during the pathogenesis of atherosclerosis in humans. Objective: The objective of this study is to study markers of purinergic signaling in a cohort of patients with peripheral artery disease. Methods and Results: Plasma ATP and ADP levels and serum nucleoside triphosphate diphosphohydrolase-1 (NTPDase1/CD39) and ecto-5′-nucleotidase/CD73 activities were measured in 226 patients with stable peripheral artery disease admitted for nonurgent invasive imaging and treatment. The major findings were that ATP, ADP, and CD73 values were higher in atherosclerotic patients than in controls without clinically evident peripheral artery disease ( P <0.0001). Low CD39 activity was associated with disease progression ( P =0.01). In multivariable linear regression models, high CD73 activity was associated with chronic hypoxia ( P =0.001). Statin use was associated with lower ADP ( P =0.041) and tended to associate with higher CD73 ( P =0.054), while lower ATP was associated with the use of angiotensin receptor blockers ( P =0.015). Conclusions: Purinergic signaling plays an important role in peripheral artery disease progression. Elevated levels of circulating ATP and ADP are especially associated with atherosclerotic diseases of younger age and smoking. The antithrombotic and anti-inflammatory effects of statins may partly be explained by their ability to lower ADP. We suggest that the prothrombotic nature of smoking could be a cause of elevated ADP, and this may explain why cardiovascular patients who smoke benefit from platelet P2Y 12 receptor antagonists more than their nonsmoking peers.

show abstract

Section: Discussionmentioning

confidence: 99%

Aberrant Circulating Levels of Purinergic Signaling Markers Are Associated With Several Key Aspects of Peripheral Atherosclerosis and Thrombosis

Jalkanen

Yegutkin

Hollmén

et al. 2015

Circulation Research

View full text Add to dashboard Cite

show abstract

“…The number of cigarettes smoked is associated with the severity of the disease and a higher risk of amputation. Moreover, in the case of vascular grafts there is a three-fold higher risk of therapy failure with continuation of smoking [10,18,19]. Several randomised studies clearly demonstrate the advantage of anti-smoking therapy with the use of substitutes for nicotine [9,10,20].…”

Section: Discussionmentioning

confidence: 99%

Cross-sectional study of the ankle–brachial index and cardiovascular risk factors in postmenopausal women

Wierzchowski

Dereziński²,

Migdalski³

et al. 2017

Kardiol Pol

View full text Add to dashboard Cite

A b s t r a c tBackground: The incidence of peripheral artery disease (PAD) and cardiovascular (CV) events in the female population has been on the increase. Aim:To analyse the risk factors of a CV event and PAD in women and to assess the usefulness of the ankle-brachial index (ABI). Methods:Evaluation of selected parameters in a cohort of 365 women living in the same district. The following data were prospectively recorded: weight, height, waist size, hip circumference, smoking, the intima-media complex, ABI value, and laboratory results. PAD symptoms, CV events and neurological events were noted. ABI was analysed assuming pathology for values: ≤ 0.9 or ≤ 1.0.Results: Age, plasma glucose level, atrial fibrillation, and nicotine addiction were correlated independently with CV disease and stroke (p < 0.001). The high-density lipoprotein cholesterol level, height, and systolic blood pressure were correlated independently with ABI values (p < 0.05). There was no correlation between the occurrence of a CV event in the past and the ABI, irrespective of the cut-off point for the reference value (p = NS). Conclusions:There is no evidence that stricter criteria for the assessment of ABI better represent the vascular status in the female population.

show abstract

“…However, smoking cessation is associated with a reduced risk of cardiovascular events and a reduced risk of amputation. Those patients that do undergo bypass surgery have a three-fold increased risk of graft failure with continued smoking which reduces to that of non-smokers with smoking cessation (Willigendael et al, 2005). These significant findings make smoking cessation a pre-requisite for any semi-elective or elective bypass surgery.…”

Section: Smoking Cessationmentioning

confidence: 99%

The Management of Peripheral Arterial Disease (PAD) in Primary Care

Coveney¹

2012

Primary Care at a Glance - Hot Topics and New Insights

View full text Add to dashboard Cite

Smoking and the patency of lower extremity bypass grafts: A meta-analysis

Cited by 168 publications

References 38 publications

Aberrant Circulating Levels of Purinergic Signaling Markers Are Associated With Several Key Aspects of Peripheral Atherosclerosis and Thrombosis

Aberrant Circulating Levels of Purinergic Signaling Markers Are Associated With Several Key Aspects of Peripheral Atherosclerosis and Thrombosis

Cross-sectional study of the ankle–brachial index and cardiovascular risk factors in postmenopausal women

The Management of Peripheral Arterial Disease (PAD) in Primary Care

Contact Info

Product

Resources

About