Smoking and SARS-CoV-2 Impair Dendritic Cells and Regulate DC-SIGN Expression in Tissues

Cai, Guoshuai; Bossé, Yohan; Du, Mulong; Albrecht, Helmut; Qin, Fei; Yu, Xuanxuan; Luo, Xizhi; Zhu, Xiaolong; Zhou, Jun; Cui, Xiang; Yi, Changhua; Cheng, Chao; Nagarkatti, Mitzi; Christiani, David C.; Whitfield, Michael L.; Amos, Christopher I.; Xiao, Feifei

doi:10.1101/2020.12.23.20245316

“…Nicotine has an important role in the regulation of ACE 2 receptors' immunomodulation, and this is shown in the fact that ex-smokers have a 25% increase in pulmonary ACE2 receptor expression over non-smokers. These findings revealed that former smokers were more susceptible to getting viruses and allowed them to enter their lungs [27]. Smoking has emerged as an independent risk not only for transmission but also for the severity of coronavirus disease 2019 (COVID-19).…”

Section: Covid-19 Primarily Targets Lung Epithelial Cells Causing Vir...mentioning

confidence: 99%

Association of smoking type, status, number times of smoking and their effect on infected people by COVID-19

,¹,

Ahmed²,

Mahmood³

2022

djm

0

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Background: Smoking has a significant role in weakening the pulmonary immune system function. Infection with infectious agents can cause more serious outcomes in the pulmonary system among people who smoke than those who do not. Objective: To show the relationship between smoking and the progression of the infectious COVID-19. Patients and Methods: A questionnaire the following data was gathered from both sexes using a Google form: age, smoking status, smoking habits, blood type, and medical conditions. Results: Results: Statistical analysis indicated that there are highly significant differences between males and females, and older patients included in the study who are infected and non-infected with COVID-19 (P < 0.01), and there are significant differences among blood groups (P < 0.05). In regard to smoking status, there are highly significant differences in the disease severity between the never-smoking group compared to current smokers (P≤0.01, P≤0.05), respectively. This differences increase with the number of times of smoking, and there is no significant difference between types of smoking between infected and non-infected groups with COVID-19. Statistical analysis indicated that there are highly significant differences in the disease severity in the male and female groups who have not smoked compared to former smokers (P < 0.01). Conclusion: Recent studies have reported the real role of the virus in the health status of smokers. However, this study showed no strong relationship between the virus and smokers.

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“…Nicotine has an important role in the regulation of ACE 2 receptors' immunomodulation, and this is shown in the fact that ex-smokers have a 25% increase in pulmonary ACE2 receptor expression over non-smokers. These findings revealed that former smokers were more susceptible to getting viruses and allowed them to enter their lungs [27]. Smoking has emerged as an independent risk not only for transmission but also for the severity of coronavirus disease 2019 (COVID-19).…”

Section: Covid-19 Primarily Targets Lung Epithelial Cells Causing Vir...mentioning

confidence: 99%

Association of smoking type, status, number times of smoking and their effect on infected people by COVID-19

,¹,

Ahmed²,

Mahmood³

2022

DJM

0

View full text Add to dashboard Cite

Background: Smoking has a significant role in weakening the pulmonary immune system function. Infection with infectious agents can cause more serious outcomes in the pulmonary system among people who smoke than those who do not. Objective: To show the relationship between smoking and the progression of the infectious COVID-19. Patients and Methods: A questionnaire the following data was gathered from both sexes using a Google form: age, smoking status, smoking habits, blood type, and medical conditions. Results: Results: Statistical analysis indicated that there are highly significant differences between males and females, and older patients included in the study who are infected and non-infected with COVID-19 (P < 0.01), and there are significant differences among blood groups (P < 0.05). In regard to smoking status, there are highly significant differences in the disease severity between the never-smoking group compared to current smokers (P≤0.01, P≤0.05), respectively. This differences increase with the number of times of smoking, and there is no significant difference between types of smoking between infected and non-infected groups with COVID-19. Statistical analysis indicated that there are highly significant differences in the disease severity in the male and female groups who have not smoked compared to former smokers (P < 0.01). Conclusion: Recent studies have reported the real role of the virus in the health status of smokers. However, this study showed no strong relationship between the virus and smokers.

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In silico study of mechanism of neem leaf (Azadirachta indica) active compound inhibits SARS CoV2 infection through inhibition of ACE2 and CD209 receptors

Damayanti

¹

,

Aini

²

,

Rachma

³

2023

The 4TH INTERNATIONAL CONFERENCE ON LIFE SCIENCE AND TECHNOLOGY (ICoLiST)

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Smoking and SARS-CoV-2 Impair Dendritic Cells and Regulate DC-SIGN Expression in Tissues

Cited by 3 publications

References 91 publications

Association of smoking type, status, number times of smoking and their effect on infected people by COVID-19

Association of smoking type, status, number times of smoking and their effect on infected people by COVID-19

Association of smoking type, status, number times of smoking and their effect on infected people by COVID-19

In silico study of mechanism of neem leaf (Azadirachta indica) active compound inhibits SARS CoV2 infection through inhibition of ACE2 and CD209 receptors

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