Smoking and risk of glioma: a meta-analysis

Mandelzweig, Lori; Novikov, Ilya; Sadetzki, Siegal

doi:10.1007/s10552-009-9386-z

Cited by 32 publications

(28 citation statements)

References 56 publications

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“…No clear association has been found between smoking and incidence of other tumours of the CNS, including glioma or meningioma, either in this cohort (Benson et al, 2008) or in other studies (Mandelzweig et al, 2009). Possible mechanisms for an association between smoking and risk of acoustic neuroma include, as well as direct effects of tobacco carcinogens, the effects of cigarette smoking on hormonal status (Kapoor and Jones, 2005); female sex hormones may have a function in development of some central nervous system tumours, including acoustic neuroma (Benson et al, 2010).…”

Section: Discussioncontrasting

confidence: 70%

Cigarette smoking and risk of acoustic neuromas and pituitary tumours in the Million Women Study

et al. 2010

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BACKGROUND:The relationship between cigarette smoking and incidence of acoustic neuromas and pituitary tumours is uncertain. METHODS: We examined the relation between smoking and risk of acoustic neuromas and pituitary tumours in a prospective study of 1.2 million middle-aged women in the United Kingdom. RESULTS: Over 10.2 million person years of follow-up, 177 women were diagnosed with acoustic neuromas and 174 with pituitary tumours. Current smokers at recruitment were at significantly reduced risk of incident acoustic neuroma compared with never smokers (adjusted relative risk (RR) ¼ 0.41, 95% confidence interval (CI) ¼ 0.24 -0.70, P ¼ 0.001). Past smokers did not have significantly different risk of acoustic neuroma than never smokers (RR ¼ 0.87, 95% CI ¼ 0.62 -1.22, P ¼ 0.4). Smoking was not associated with incidence of pituitary tumours (RR in current vs never smokers ¼ 0.91, 95% CI ¼ 0.60 -1.40, P ¼ 0.7). CONCLUSION: Women who smoke are at a significantly reduced risk of acoustic neuromas, but not of pituitary tumours, compared with never smokers. Acoustic neuromas are much rarer than the cancers that are increased among smokers.

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Section: Discussioncontrasting

confidence: 70%

Cigarette smoking and risk of acoustic neuromas and pituitary tumours in the Million Women Study

et al. 2010

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“…However, previous epidemiologic research has not provided a clear indication of whether smoking can increase the risk of brain tumours. While most studies have failed to demonstrate any excess risks [5,13-20,25-27,30-32], some studies have found excess risks in their entire population or in some subpopulation [28,29,34,35]. …”

Section: Discussionmentioning

confidence: 99%

“…Among cohort studies, some found no association [25-27] and some found significant positive associations in women but not men [28] and in a study of women only [29]. A recent meta-analysis on smoking and glioma found no overall association when case–control and cohort studies were pooled, although there was a small but significant increased risk among cohort studies [30]. For meningioma, some case–control studies found no evidence of increased risk [16,27,31,32] and others found an association in one sex but not the other [17,18,33-35].…”

Section: Introductionmentioning

confidence: 99%

Brain tumours and cigarette smoking: analysis of the INTERPHONE Canada case–control study

et al. 2014

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BackgroundThere is conflicting evidence regarding the associations between cigarette smoking and glioma or meningioma. Our purpose is to provide further evidence on these possible associations.MethodsWe conducted a set of case–control studies in three Canadian cities, Montreal, Ottawa and Vancouver. The study included 166 subjects with glioma, 93 subjects with meningioma, and 648 population-based controls. A lifetime history of cigarette smoking was collected and various smoking indices were computed. Multivariable logistic regression was used to estimate odds ratios (ORs) between smoking and each of the two types of brain tumours.ResultsAdjusted ORs between smoking and each type of brain tumour were not significantly elevated for all smokers combined or for smokers with over 15 pack-years ((packs / day) x years) accumulated. We tested for interactions between smoking and several sociodemographic variables; the interaction between smoking and education on glioma risk was significant, with smoking showing an elevated OR among subjects with lower education and an OR below unity among subjects with higher education.ConclusionExcept for an unexplained and possibly artefactual excess risk in one population subgroup, we found little or no evidence of an association between smoking and either glioma or meningioma.

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“…A study on a population of 22.946 icelanders, also found smoking as a risk factor of cancer for all sites, except endometrium (85). Multiple studies did not find any relation between smoking and glioma risk (82,(86)(87)(88), while others have mixed conclusions (89). Alcohol and cigarette smoking are not currently considered to be risk factors for malignant brain tumors (90).…”

Section: Lifestyle Factorsmentioning

confidence: 99%

Risk factors for gliomas. An extensive review

Florian¹,

Ungureanu²,

Berce³

2013

Romanian Neurosurgery

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Smoking and risk of glioma: a meta-analysis

Abstract: Overall, results of pooling of all studies suggested that smoking is not associated with risk of glioma. However, the small but significant increased risk seen for cohort studies remains to be clarified.

Cited by 32 publications

References 56 publications

Cigarette smoking and risk of acoustic neuromas and pituitary tumours in the Million Women Study

Cigarette smoking and risk of acoustic neuromas and pituitary tumours in the Million Women Study

Brain tumours and cigarette smoking: analysis of the INTERPHONE Canada case–control study

Risk factors for gliomas. An extensive review

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