Smoking and plastic surgery, part II. Clinical implications: A systematic review with meta-analysis

Pluvy, I.; Panouilleres, Marie; Garrido, I.; Pauchot, J.; Saboye, J.; Chavoin, J.-P.; Tropet, Y.; Grolleau, J L; Chaput, Benoît

doi:10.1016/j.anplas.2014.09.011

Cited by 72 publications

(37 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Over the last few decades, there has been an increasing amount of evidence supporting the association between smoking and woundrelated complications. 22,35 However, there is limited literature examining the link between smoking or diabetes and hematoma formation in the aesthetic population. A retrospective study of 1936 breast augmentations showed no statistically significant association between smoking and postoperative hematoma.…”

Section: Risk Factorsmentioning

confidence: 99%

Incidence and Risk Factors for Major Hematomas in Aesthetic Surgery: Analysis of 129,007 Patients

Kaoutzanis

Winocour

Gupta

et al. 2017

Aesthetic Surgery Journal

View full text Add to dashboard Cite

Background: Postoperative hematomas are one of the most frequent complications following aesthetic surgery. Identifying risk factors for hematoma has been limited by underpowered studies from single institution experiences. Objectives: To examine the incidence and identify independent risk factors for postoperative hematomas following cosmetic surgery utilizing a prospective, multicenter database. Methods: A prospectively enrolled cohort of patients who underwent aesthetic surgery between 2008 and 2013 was identified from the CosmetAssure database. Primary outcome was occurrence of major hematomas requiring emergency room visit, hospital admission, or reoperation within 30 days of the index operation. Univariate and multivariate analysis was used to identify potential risk factors for hematomas including age, gender, body mass index (BMI), smoking, diabetes, type of surgical facility, procedure by body region, and combined procedures. Results: Of 129,007 patients, 1180 (0.91%) had a major hematoma. Mean age (42.0 ± 13.0 years vs 40.9 ± 13.9 years, P < 0.01) and BMI (24.5 ± 5.0 kg/m 2 vs 24.3 ± 4.6 kg/m 2 , P < 0.01) were higher in patients with hematomas. Males suffered more hematomas than females (1.4% vs 0.9%, P < 0.01). Hematoma rates were higher in patients undergoing combined procedures compared to single procedures (1.1% vs 0.8%, P < 0.01), and breast procedures compared to body/extremity or face procedures (1.0% vs 0.8% vs 0.7%, P < 0.01). On multivariate analysis, independent predictors of hematoma included age (Relative Risk [RR] 1.01), male gender (RR 1.98), the procedure being performed in a hospital setting rather than an office-based setting (RR 1.68), combined procedures (RR 1.35), and breast procedures rather than the body/extremity and face procedures (RR 1.81). Conclusions: Major hematoma is the most common complication following aesthetic surgery. Male patients and those undergoing breast or combined procedures have a significantly higher risk of developing hematomas.

show abstract

Section: Risk Factorsmentioning

confidence: 99%

Incidence and Risk Factors for Major Hematomas in Aesthetic Surgery: Analysis of 129,007 Patients

Kaoutzanis

Winocour

Gupta

et al. 2017

Aesthetic Surgery Journal

View full text Add to dashboard Cite

show abstract

“…We can make several assumptions to explain this finding. Multiple risk factors increasing the incidence of postoperative complications have been proposed, including smoking 18 and obesity. 19 Our demographic characteristics showed no statistical differences between both groups regarding these risk factors.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Autologous Platelet-rich Plasma Glue in Weight Loss Sequelae Surgery and Breast Reduction: A Prospective Study

Hersant

SidAhmed-Mezi

Padula

et al. 2016

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

Background:Seroma and hematoma formations are the most common complications after plastic surgery. The aim of this study was to assess the efficacy of autologous platelet-rich plasma (A-PRP) glue to reduce postoperative wound complications and improve surgical outcomes.Methods:Fifty-four patients were included in this study. They underwent breast reduction surgery, abdominoplasty, or limb lifting with A-PRP glue application on the entire surface of the subcutaneous tissue at the time of suture. Retrospective data were used for the control group. The primary endpoint was the incidence of postoperative seroma or hematoma. The secondary endpoint was the Patient and Observer Scar Assessment Scale score.Results:Demographics and clinical characteristics were not statistically different between the A-PRP glue group and the control group regarding age, sex ratio, and body mass index. After abdominoplasty, 37.5% of patients (3/8) in the control group experienced seroma and hematoma complications versus 12.5% of patients (2/16) in the A-PRP glue group (P = 0.55 and P = 0.25, respectively). After limb lifting, 50% of patients experienced postoperative complications in the control group versus no patient in the A-PRP glue group (P = 0.03*; * indicates that the P value is significant). After breast reduction, no patient experienced complication in the A-PRP glue group versus 25% of patients in the control group who experienced hematoma (P = 0.04*). The scar quality assessed 12 months after surgery showed no statistical differences between the groups.Conclusions:A-PRP glue seems effective to prevent seroma formation after limb lifting and hematoma formation after breast reduction. Wound-healing quality did not seem to be improved.

show abstract

“…At first, migrated nasal fibroblast cells fabricate early ECM and granulation tissue through protein synthesis and growth factor secretion. Until 6 months postsurgery, continuous synthesis and degradation of ECM form the wound remodeling phase . Such dynamic balance is important for wound maturation.…”

Section: Discussionmentioning

confidence: 99%

“…It has been well established that smoking has a deteriorating effect on cell physiological functions such as wound healing and tissue repair mechanisms, cell viability, cell adhesion, cell migration, myofibroblast differentiation, and tissue remodeling in the lungs . Moreover, a recent systematic review on the relation between smoking and wound healing after surgery showed that smoking significantly delays postsurgical wound healing . Furthermore, smoking has been reported to be closely associated with success and recovery of patients post–endoscopic sinus surgery .…”

mentioning

confidence: 99%

Cigarette smoke extract inhibits cell migration and contraction via the reactive oxygen species/adenosine monophosphate–activated protein kinase pathway in nasal fibroblasts

Shin

Park

Yang

et al. 2019

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background Fibroblast migration plays a significant role in wound healing after endoscopic sinonasal surgery. Cigarette smoke extract (CSE) is a potent inhibitor of fibroblast functions including cell proliferation and migration. The purpose of the study was to determine the influence of CSE on migration and collagen gel contraction in nasal fibroblasts and investigate its underlying mechanisms. Methods Fibroblast migration was evaluated using wound healing assay and transwell migration assay. Contractile activity was assessed by collagen gel contraction assay. Reactive oxygen species (ROS) were quantified by 2′,7′‐dichlorofluorescein diacetate. Fibroblasts were treated with CSE and N‐acetylcysteine (NAC), metformin, compound C, or transfected with small interfering RNA (siRNA) to suppress adenosine monophosphate–activated protein kinase (AMPK) expression. AMPK activation was determined by Western blot. Results CSE and metformin were found to significantly reduce the migration and collagen gel contraction activity of nasal fibroblasts. Conversely, pretreatment with NAC and compound C significantly enhanced the migration and collagen gel contraction activity of fibroblasts. ROS production and AMPK phosphorylation were found to be significantly induced by CSE treatment, whereas the activity was inhibited on treatment with NAC, metformin, compound C, or AMPK siRNA. Silencing of AMPK expression was found to significantly reverse the suppressive effect of CSE in nasal fibroblasts. Conclusion CSE has an inhibitory effect on cell migration and collagen gel contraction activity via the ROS/AMPK signaling pathway in nasal fibroblasts.

show abstract

Smoking and plastic surgery, part II. Clinical implications: A systematic review with meta-analysis

Cited by 72 publications

References 105 publications

Incidence and Risk Factors for Major Hematomas in Aesthetic Surgery: Analysis of 129,007 Patients

Incidence and Risk Factors for Major Hematomas in Aesthetic Surgery: Analysis of 129,007 Patients

Efficacy of Autologous Platelet-rich Plasma Glue in Weight Loss Sequelae Surgery and Breast Reduction: A Prospective Study

Cigarette smoke extract inhibits cell migration and contraction via the reactive oxygen species/adenosine monophosphate–activated protein kinase pathway in nasal fibroblasts

Contact Info

Product

Resources

About