Smoking and FOS expression from blood leukocyte transcripts in patients with coronary artery disease

Saliques, Sébastien; Teyssier, Jean-Raymond; Vergely, Catherine; Lorgis, Luc; Lorin, Julie; Donzel, Anne; Sicard, Pierre; Berchoud, Juliane; Ragot, Sylviane; Touzery, Claude; Cottin, Yves; Rochette, Luc; Zeller, Marianne

doi:10.1016/j.atherosclerosis.2011.09.026

Cited by 12 publications

(8 citation statements)

References 27 publications

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“…Studies indicated that lipoic acid scavenges hydroxyl radicals, hypochlorous acid and singlet oxygen. In our Laboratory, where we have developed several projects in the field of oxidative stress associated with cardiovascular disease [40][41][42][43][44], we also observed that lipoic acid was able to diminish the superoxide-driven oxidation of a sensitive spin probe, in a manner comparable to that of superoxide dismutase; this effect being not noted with all the antioxidant agents [45]. It can be stated that the sites of reaction of antioxidant agents are not always the same.…”

Section: Discussionmentioning

confidence: 59%

Carbon Monoxide Protects Against Ischemia-reperfusion Injuryin Vitrovia Antioxidant Properties

Berne¹,

Lauzier²,

Rochette³

et al. 2012

Cell Physiol Biochem

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Carbon monoxide (CO) is believed to mediate many of the cytoprotective effects attributed to the activation of heme oxygenase (HO-1), the enzyme responsible for CO production. Recently, the study of CO-releasing molecules (CO-RMs) has provided a new approach for the delivery of CO. In the present study, we examined whether the cardioprotective properties of CO-RM2 in isolated rat hearts subjected to an ischemia-reperfusion (I/R) sequence were associated with the presence of CO. In addition, the antioxidant properties of CO-RM2 were evaluated. In hearts pretreated with CO-RM2, the improvement in contractile function at the end of the reperfusion period after 20 min of global total ischemia was significantly greater than in controls. These beneficial effects were accompanied by a reduction in 1) LDH activity release 2) infarct size 3) ventricular superoxide production. The improvement in myocardial function and the reduction in oxidative stress were not observed when hearts were pretreated with inactivated CO-RM2 (iCO-RM2). Additionally, CO-RM2, but not iCO-RM2, was found to exert antioxidant properties. These results suggest that the production of CO is a necessary factor in the cardioprotective and antioxidant actions of CO-releasing compound. These results may open up new ground for a novel class of cardioprotective compounds.

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Section: Discussionmentioning

confidence: 59%

Carbon Monoxide Protects Against Ischemia-reperfusion Injuryin Vitrovia Antioxidant Properties

Berne¹,

Lauzier²,

Rochette³

et al. 2012

Cell Physiol Biochem

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“…The steady state amounts of mRNA and the MTL have been assessed by the relative, real-time quantitative polymerase chain reaction method (rQ-PCR), as previously described [34], [35].…”

Section: Methodsmentioning

confidence: 99%

Up-Regulation of leucocytes Genes Implicated in Telomere Dysfunction and Cellular Senescence Correlates with Depression and Anxiety Severity Scores

Teyssier

Chauvet-Gélinier

Ragot³

et al. 2012

PLoS ONE

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BackgroundMajor depressive disorder (MDD) is frequently associated with chronic medical illness responsible of increased disability and mortality. Inflammation and oxidative stress are considered to be the major mediators of the allostatic load, and has been shown to correlate with telomere erosion in the leucocytes of MDD patients, leading to the model of accelerated aging. However, the significance of telomere length as an exclusive biomarker of aging has been questioned on both methodological and biological grounds. Furthermore, telomeres significantly shorten only in patients with long lasting MDD. Sensitive and dynamic functional biomarkers of aging would be clinically useful to evaluate the somatic impact of MDD.MethodologyTo address this issue we have measured in the blood leucocytes of MDD patients (N = 17) and controls (N = 16) the expression of two genes identified as robust biomarkers of human aging and telomere dysfunction: p16INK4a and STMN1. We have also quantified the transcripts of genes involved in the repair of oxidative DNA damage at telomeres (OGG1), telomere regulation and elongation (TERT), and in the response to biopsychological stress (FOS and DUSP1).ResultsThe OGG1, p16INK4a, and STMN1 gene were significantly up-regulated (25 to 100%) in the leucocytes of MDD patients. Expression of p16INK4a and STMN1 was directly correlated with anxiety scores in the depression group, and that of p16INK4a, STMN and TERT with the depression and anxiety scores in the combined sample (MDD plus controls). Furthermore, we identified a unique correlative pattern of gene expression in the leucocytes of MDD subjects.ConclusionsExpression of p16INK4 and STMN1 is a promising biomarker for future epidemiological assessment of the somatic impact of depressive and anxious symptoms, at both clinical and subclinical level in both depressive patients and general population.

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“…Aging-related endothelial dysfunction involves increased oxidative stress, the activation of inflammatory pathways, and impaired regeneration of ECs. Multiple mechanisms responsible for cellular senescence have been proposed, among which the shortening of telomeres associated with the increased oxidative stress appears to be the most important [82]. It is now recognized that OPG participates in protection against atherosclerosis and vascular calcification.…”

Section: Opg/rankl/rank and Cellular Senescencementioning

confidence: 99%

The Role of Osteoprotegerin and Its Ligands in Vascular Function

Rochette

Méloux

Rigal

et al. 2019

IJMS

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112

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The superfamily of tumor necrosis factor (TNF) receptors includes osteoprotegerin (OPG) and its ligands, which are receptor activators of nuclear factor kappa-B ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL). The OPG/RANKL/RANK system plays an active role in pathological angiogenesis and inflammation as well as cell survival. It has been demonstrated that there is crosstalk between endothelial cells and osteoblasts during osteogenesis, thus establishing a connection between angiogenesis and osteogenesis. This OPG/RANKL/RANK/TRAIL system acts on specific cell surface receptors, which are then able to transmit their signals to other intracellular components and modify gene expression. Cytokine production and activation of their receptors induce mechanisms to recruit monocytes and neutrophils as well as endothelial cells. Data support the role of an increased OPG/RANKL ratio as a possible marker of progression of endothelial dysfunction in metabolic disorders in relationship with inflammatory marker levels. We review the role of the OPG/RANKL/RANK triad in vascular function as well as molecular mechanisms related to the etiology of vascular diseases. The potential therapeutic strategies may be very promising in the future.

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Smoking and FOS expression from blood leukocyte transcripts in patients with coronary artery disease

Cited by 12 publications

References 27 publications

Carbon Monoxide Protects Against Ischemia-reperfusion Injuryin Vitrovia Antioxidant Properties

Carbon Monoxide Protects Against Ischemia-reperfusion Injuryin Vitrovia Antioxidant Properties

Up-Regulation of leucocytes Genes Implicated in Telomere Dysfunction and Cellular Senescence Correlates with Depression and Anxiety Severity Scores

The Role of Osteoprotegerin and Its Ligands in Vascular Function

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