Smoking and Colorectal Cancer in Lynch Syndrome: Results from the Colon Cancer Family Registry and The University of Texas M.D. Anderson Cancer Center

Pande, Mala; Lynch, Patrick M.; Hopper, John L.; Jenkins, Mark A.; Gallinger, Steve; Haile, Robert W.; LeMarchand, Loïc; Lindor, Noralane M.; Campbell, Peter T.; Newcomb, Polly A.; Potter, John D.; Baron, John A.; Frazier, Marsha L.; Amos, Christopher I.

doi:10.1158/1078-0432.ccr-09-1877

Cited by 63 publications

(41 citation statements)

References 34 publications

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“…We have shown that body mass index in early adulthood is similarly associated with CRC risk for both carriers and noncarriers (93). Studies of alcohol consumption (94), fruit consumption (95), dietary fiber intake (95), smoking (95,96) have not directly compared strengths of associations for carriers with noncarriers.…”

Section: Environmental Factorsmentioning

confidence: 99%

Risk Prediction Models for Colorectal Cancer: A Review

Win

MacInnis

Hopper

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Risk prediction models are important to identify individuals at high risk of developing the disease who can then be offered individually tailored clinical management, targeted screening and interventions to reduce the burden of disease. They are also useful for research purposes when attempting to identify new risk factors for the disease. In this article, we review the risk prediction models that have been developed for colorectal cancer and appraise their applicability, strengths, and weaknesses. We also discuss the factors to be considered for future development and improvement of models for colorectal cancer risk prediction. We conclude that there is no model that sufficiently covers the known risk factors for colorectal cancer that is suitable for assessment of people from across the full range of risk and that a new comprehensive model is needed. Cancer Epidemiol Biomarkers Prev; 21(3); 398-410. Ó2011 AACR.

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Section: Environmental Factorsmentioning

confidence: 99%

Risk Prediction Models for Colorectal Cancer: A Review

Win

MacInnis

Hopper

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The lifetime probability of developing colorectal cancer is estimated to be 54% to 74% for men and 30% to 52% for women with Lynch syndrome, compared to 5% to 6% for the general population (8,9,10). Various health behaviours have been demonstrated to reduce the risk of hereditary colorectal cancer in Lynch syndrome families, such as colonoscopy use (11,12), smoking (13,14), and other lifestyle behaviours, including diet (15). Based on data availability, this study focused on colonoscopy and smoking behaviours.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Receiving Predictive Genetic Information about Lynch Syndrome on Individual Colonoscopy and Smoking Behaviors

Kim

Coyte

Cotterchio

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background This study investigated whether receiving the results of predictive genetic testing for Lynch syndrome—indicating the presence or absence of an inherited predisposition to various cancers, including colorectal cancer—was associated with change in individual colonoscopy and smoking behaviours, which could prevent colorectal cancer. Methods The study population included individuals with no previous diagnosis of colorectal cancer, whose families had already-identified deleterious mutations in the mismatch repair or EPCAM genes. Hypotheses were generated from a simple health economics model and tested against individual-level panel data from the Australasian Colorectal Cancer Family Registry. Results The empirical analysis revealed evidence consistent with some of the hypotheses, with a higher likelihood of undergoing colonoscopy in those who discovered their genetic predisposition to colorectal cancer and a lower likelihood of quitting smoking in those who discovered their lack thereof. Conclusion Predictive genetic information about Lynch syndrome was associated with change in individual colonoscopy and smoking behaviours but not necessarily in ways to improve population health. Impact The study findings suggest that the impact of personalized medicine on disease prevention is intricate, warranting further analyses to determine the net benefits and costs.

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“…The prevalence of LS may differ among ethnicities, races and countries because of a lack of sufficient data and may be influenced by selection biases in studies or by the age distribution of the study cohort. In addition, a lifetime risk of developing CRC among carriers of the mutations may be influenced by environmental factors and the lifestyles (14)(15)(16)(17). Under these circumstances, there have been no credible data on the prevalence of LS among CRC patients in Japan, which represents one of the most rapidly aging societies in the world, and where CRC was estimated in 2015 as being the most frequently occurring of all malignant tumors and also as being the first and second leading causes of death in women and men, respectively (18).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Lynch syndrome and Lynch-like syndrome among patients with colorectal cancer in a Japanese hospital-based population

Chika

Eguchi

Kumamoto

et al. 2016

Japanese Journal of Clinical Oncology

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Objective: We investigated the prevalence of Lynch syndrome and Lynch-like syndrome among Japanese colorectal cancer patients, as there have been no credible data from Japan. Methods: Immunohistochemical analyses for mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2) were carried out in surgically resected, formalin-fixed paraffin-embedded specimens obtained from 1,234 newly diagnosed colorectal cancer patients between March 2005 and April 2014. The presence/absence of the BRAF V600E mutation and hypermethylation of the MLH1 promoter was analyzed where necessary. Genetic testing was finally undertaken in patients suspected as having Lynch syndrome. Results: By the universal screening approach with immunohistochemical analysis for mismatch repair proteins followed by analyses for the BRAF V600E mutation and MLH1 promoter methylation status, 11 (0.9%) of the 1,234 patients were identified as candidates for genetic testing. Out of the 11 patients, 9 (0.7%) were finally diagnosed as having Lynch syndrome; the responsible genes included MLH1 (n = 1), MSH2 (n = 4), EPCAM (n = 1) and MSH6 (n = 3). The remaining two patients (0.2%) were regarded as having Lynch-like syndrome, since biallelic somatic deletion of the relevant mismatch repair genes was detected in the absence of germline mismatch repair alterations. None of the cases was identified as having germline MLH1 epimutation. Conclusions: The prevalence of Lynch syndrome among all newly diagnosed cases of colorectal cancer in Japan is in the same range as that recently reported by studies in Western population. The prevalence of Lynch-like syndrome seems to be extremely low.

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Smoking and Colorectal Cancer in Lynch Syndrome: Results from the Colon Cancer Family Registry and The University of Texas M.D. Anderson Cancer Center

Cited by 63 publications

References 34 publications

Risk Prediction Models for Colorectal Cancer: A Review

Risk Prediction Models for Colorectal Cancer: A Review

The Impact of Receiving Predictive Genetic Information about Lynch Syndrome on Individual Colonoscopy and Smoking Behaviors

Prevalence of Lynch syndrome and Lynch-like syndrome among patients with colorectal cancer in a Japanese hospital-based population

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