Smoking and apolipoprotein levels: A meta-analysis of published data

Effects of cigarette smoking on semen quality, reproductive hormone levels, metabolic profile, zinc and sperm DNA fragmentation in men: results from a population-based study

“…The results of our study showed that cigarette smoking had an adverse effect on the metabolic health of smokers (an increase in triglycerides and uric acid, as well as a decrease in the HDL-C), which corresponds to the data obtained in other studies ( 71 , 89 – 91 ). A meta-analysis conducted by Kauss and co-authors demonstrated that smoking was also associated with a decrease in the levels of apolipoproteins AI and AII and an increase in the level of apolipoprotein B, thereby confirming the negative impact of smoking on lipid metabolism ( 92 ). A possible mechanism for how cigarette smoking can alter the lipid profile has been proposed ( 92 , 93 ).…”

“…A meta-analysis conducted by Kauss and co-authors demonstrated that smoking was also associated with a decrease in the levels of apolipoproteins AI and AII and an increase in the level of apolipoprotein B, thereby confirming the negative impact of smoking on lipid metabolism ( 92 ). A possible mechanism for how cigarette smoking can alter the lipid profile has been proposed ( 92 , 93 ). During cigarette smoking, nicotine stimulates the secretion of catecholamines and cortisol, activating adenylcyclase in adipose tissue, which leads to both lipolysis and the release of free fatty acids into the circulation, as well as to an increase in the lipoprotein production, including the HDL concentration.…”

Insulin resistance and metabolic syndrome in hepatitis C virus seronegative heroin dependents

“…The apoB was considered as the most significant marker of the atherogenic potential in the body and strongly correlated with the ultrasonographic finding of atherosclerotic changes of blood vessels and the occurrence of MS in the general population. The presented apolipoprotein levels in HDM+ group could be partially explained by the significantly increased cumulative index of cigarette smoking, Brinkman index, i.e, decreased apoA-I with increased apoB profile was associated with cigarette smoking 48 .…”

“…Hypoadiponectinemia also correlates with an increased hepatic lipase activity increasing the catabolism of HDL-C and apoA-I 47 . Of course, cigarette smoking and alcohol are significant mechanisms that participate in less than 50% of the variation of HDL-C values in the general population and in the population of HD, in addition to TGl, cholesterol and IR 48 . Considering the protective functions of apoA-I and HDL-C, several controlled epidemiological studies have confirmed the existence of a significant inverse association between HDL-C and its major lipoprotein ApoA-I with a high cardiovascular risk and atherosclerosis.…”

Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation

“…In fact, smoking induced endothelial dysfunction and damage, increasing lipid oxidation, decreasing HDL, and promoting inflammation, and a pro-thrombotic state ( 146 , 147 ). Furthermore, a worse lipid profile characterized by increased ApoB and reduced ApoA-I and ApoA-II was reported in smokers compared to non-smokers independently from their sex ( 148 ). Interestingly, smoking was reported as a stronger risk factor for CVD in women than in men accordingly to the Finnmark Study ( 149 ).…”