Smoking, alcohol and family history of cancer as risk factors for small intestinal neuroendocrine tumors: a systematic review and meta-analysis

Haugvik, Sven-Petter; Ibrahim, Ibrahim Basim; Hedenström, Per; Valente, Roberto; Hayes, Alastair; Siuka, Darko; Gladhaug, Ivar P.; Capurso, Gabriele

doi:10.1080/00365521.2017.1310290

Cited by 22 publications

(16 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cancer constitutes a global burden and has become a serious health challenge ( 1 , 2 ). The occurrence of cancer is increasing due to an increasing aging population and prevalence of established risk factors ( 3 – 6 ). Although over the last few decades, novel therapeutic strategies have been developed, the prognosis and survival rate for patients with cancer is far from satisfactory.…”

Section: Introductionmentioning

confidence: 99%

Effects of aspirin on proliferation, invasion and apoptosis of Hep‑2 cells via the PTEN/AKT/NF‑κB/survivin signaling pathway

Jin

Zhang³

et al. 2018

Oncol Lett

View full text Add to dashboard Cite

Aspirin may exhibit antitumor activities, as it is able to inhibit cell proliferation. However, the ability of aspirin to inhibit cellular proliferation in Hep-2 cells and its underlying molecular mechanisms have been poorly determined. The aim of the present study was to investigate whether aspirin may induce cell apoptosis in the neoplastic cell line Hep-2. The effects of aspirin on the migratory and invasive abilities of Hep-2 cells were also investigated using Transwell assays. In the present study, it was demonstrated that aspirin induced apoptosis and inhibited proliferation, migration and invasion in Hep-2 cells. Aspirin also significantly decreased the expression of B-cell lymphoma 2 (Bcl-2) and caspase-3, and increased the expression of Bcl-2-associated X protein, suggesting that aspirin induced apoptosis through the intrinsic apoptotic pathway. Hep-2 cells treated with aspirin exhibited a significant upregulation of phosphatase and tensin homolog (PTEN) and decreased levels of phosphorylated protein kinase B (AKT). However, the total amount of AKT protein was not altered in response to aspirin treatment. Furthermore, the expression of nuclear factor (NF)-κB and survivin, which are the downstream targets of the PTEN/AKT signaling pathway, was inhibited. These results indicated that the molecular mechanism underlying the antitumor effects of aspirin may be associated with the inhibition of tumor invasion and induction of apoptosis by regulating the activity of the PTEN/AKT/NF-κB/survivin signaling pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of aspirin on proliferation, invasion and apoptosis of Hep‑2 cells via the PTEN/AKT/NF‑κB/survivin signaling pathway

Jin

Zhang³

et al. 2018

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…Haugvik et al performed a metaanalysis for risk factors of pancreatic NETs and reported that diabetes, family history of cancer, alcohol, and smoking were risk factors [16]. The other risk factors for NETs in sites other than pancreas include family history of carcinoid or other cancers, race, sex, age, alcohol drinking, social economic status, obesity, smoking, and LDL-cholesterol level [17][18][19][20][21]. However, more investigations are needed to generate solid evidence.…”

Section: Discussionmentioning

confidence: 99%

The epidemiologic trends of neuroendocrine tumors in Taiwan: an updated analysis of a nation-wide population-based study

Chang

Chen

Shan

et al. 2020

Preprint

View full text Add to dashboard Cite

Background The incidence of neuroendocrine tumors (NETs) has been increasing in recent decades and there has been a rising awareness by the physicians for the diagnosis of NETs. Several novel agents have been developed and demonstrated to improve the survival of NETs recently. Previously, we reported the incidence and survival of NETs in Taiwan by analyzing the 1996–2008 data from the Taiwan Cancer Registry (TCR). Here we performed an updated analysis on the incidence and survival of NETs in Taiwan from 1996 to 2015. Methods Data for the current analysis were obtained from the TCR and the Death Registry Database. The incidence was age-standardized to the WHO 2000 population and the overall survival was calculated by life-table method. The risk of NETs death was evaluated by performing Cox proportional hazards regression analysis. Results There were a total of 7,760 cases of NETs diagnosed during 1996–2015. The most common site of NETs was rectum (29.65%), followed by lung and bronchus (17.22%), and pancreas (10.71%). The incidence of NETs was 0.244 per 100,000 in 1996 and increased to 3.162 per 100,000 in 2015 with an annual percentage change (APC) of 15.44 (P < 0.0001). The site with the most rapid increase was pancreas with an APC of 28.04 (P < 0.0001). The 5- and 10-year survival rates of all NETs were 54.6% and 45.3%, respectively. Female and younger NETs patients had a better survival. The HR for survival of all NETs diagnosed between 2010 and 2015 was 0.91 (95%CI, 0.84–0.99) compared to those diagnosed between 2004 and 2009. Among the common sites of NETs, an improved survival of NETs diagnosed between 2010 and 2015 compared to those diagnosed between 2004 and 2009 was only observed in pancreatic NET (HR = 0.52, 95% CI, 0.41–0.66). This result was likely due to the early diagnosis and improvement in the treatment of pancreatic NET. Conclusions Overall, the incidence of NETs in Taiwan has continued to increase. The survival of pancreatic NET has shown recent improvement. The development of novel therapeutic agents has the potential to improve the prognosis of NETs of other primary sites in the near future.

show abstract

“…Incidence of carcinoid tumors is about 2.47 (0.87 for small intestine alone) per 100,000 population per year with the incidence having increased 3-fold over the past 40 years [1,2]. Multiple factors likely contribute to the rise in incidence of small intestinal neuroendocrine (carcinoid) tumors (SINT) including better and more accurate detection, tobacco use, and changes in environmental exposures [3][4][5][6]. Tobacco use has declined since its peak in the 1960's, however the lag time from tobacco exposure to cancer later in life is consistent with the recent rise in incidence of SINT [7].…”

Section: Introductionmentioning

confidence: 99%

“…Cigarette smoking and alcohol have been associated with an elevated risk of SINT, but reports are varied. In a meta-analysis including patients from the U.S.A. and Europe, an odds ratio of 1.40 (1.06-1.86) was observed for smoking and 1.04 (0.63-1.72) for alcohol [6]. In Utah, we observed an odds ratio of 1.44 (1.11-1.86) for smoking and 1.62 (1.05-2.49) for alcohol and risk of SINT [13].…”

Section: Introductionmentioning

confidence: 99%

Early life exposures associated with risk of small intestinal neuroendocrine tumors

et al. 2020

View full text Add to dashboard Cite

Small intestinal neuroendocrine tumors (SINT) are rare with incidence increasing over the past 40 years. The purpose of this work is to examine the role of environmental exposures in the rise of SINT incidence using the Utah Population Database, a resource of linked records including life events, cancer diagnoses and residential histories. SINT cases born in Utah were identified through the Utah Cancer Registry with: diagnosis years of 1948 to 2014 and age at diagnosis of 23 to 88 years. Controls were matched to cases 10:1 based on sex, birth year and residence time in Utah. Cases and controls were geocoded to their birth locale. An isotonic spatial scan statistic was used to test for the occurrence and location(s) of SINT clusters. Potential environmental exposures and economic conditions in the birth locales at the time of the birth (1883-1982) were generated using historical references. Conditional logistic regression was used to estimate odd ratios. We report a spatial cluster central to historic coal mining communities, associated with a 2.86 relative risk (p = 0.016) of SINT. Aspatial analyses of industry and mining exposures further suggest elevated risk for early life exposure near areas involved in the construction industry (OR 1.98 p = 0.024). Other exposures approached significance including coal, uranium and hard rock mining during the earliest period (1883-1929) when safety from exposures was not considered. We do observe a lower risk (OR 0.58 p = 0.033) associated with individuals born in rural areas in the most recent period (1945-1982). Environmental exposures early in life, especially those from industries such as mining, may confer an elevated risk of SINT.

show abstract

Smoking, alcohol and family history of cancer as risk factors for small intestinal neuroendocrine tumors: a systematic review and meta-analysis

Cited by 22 publications

References 21 publications

Effects of aspirin on proliferation, invasion and apoptosis of Hep‑2 cells via the PTEN/AKT/NF‑κB/survivin signaling pathway

Effects of aspirin on proliferation, invasion and apoptosis of Hep‑2 cells via the PTEN/AKT/NF‑κB/survivin signaling pathway

The epidemiologic trends of neuroendocrine tumors in Taiwan: an updated analysis of a nation-wide population-based study

Early life exposures associated with risk of small intestinal neuroendocrine tumors

Contact Info

Product

Resources

About