Smoking, aging, and expression of proteins related to the FOXO3 signaling pathway in lung tissues

Yuan, Yitong; Luo, Li; Guo, Ziyan; Yang, Ming; Lin, Yixin; Luo, Chi‐Cheng

doi:10.4238/2015.july.31.2

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…Additionally, Akt expression and activation in the mouse skin increases with age [ 61 ]. Smoking inactivates FoxO3, which accelerates the aging of lung tissue during chronic obstructive pulmonary disease [ 62 ]. Cells with depletion of FoxO1 exhibited a change in the usage of metabolic substrates from free fatty acids to glucose, which is associated with decreasing lipid accumulation in the heart.…”

Section: Differential Roles Of Akt/foxos Axis In Metabolic- and Non-metabolic Organsmentioning

confidence: 99%

“…We previously reported that Akt-induced FoxO1 phosphorylation was reduced in the livers of aged rats, whereas it was increased in the kidney [ 65 ]. Different trends of changes in the Akt/FoxOs axis in metabolic and non-metabolic organs during aging are shown in Table 1 [ 31 , 32 , 60 - 62 , 66 - 73 ].…”

Section: Differential Roles Of Akt/foxos Axis In Metabolic- and Non-metabolic Organsmentioning

confidence: 99%

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Organ-differential Roles of Akt/FoxOs Axis as a Key Metabolic Modulator during Aging

Kim

Bang

et al. 2021

Aging and disease

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FoxOs and their post-translational modification by phosphorylation, acetylation, and methylation can affect epigenetic modifications and promote the expression of downstream target genes. Therefore, they ultimately affect cellular and biological functions during aging or occurrence of age-related diseases including cancer, diabetes, and kidney diseases. As known for its key role in aging, FoxOs play various biological roles in the aging process by regulating reactive oxygen species, lipid accumulation, and inflammation. FoxOs regulated by PI3K/Akt pathway modulate the expression of various target genes encoding MnSOD, catalases, PPARγ, and IL-1β during aging, which are associated with age-related diseases. This review highlights the age-dependent differential regulatory mechanism of Akt/FoxOs axis in metabolic and non-metabolic organs. We demonstrated that age-dependent suppression of Akt increases the activity of FoxOs (Akt/FoxOs axis upregulation) in metabolic organs such as liver and muscle. This Akt/FoxOs axis could be modulated and reversed by antiaging paradigm calorie restriction (CR). In contrast, hyperinsulinemia-mediated PI3K/Akt activation inhibited FoxOs activity (Akt/FoxOs axis downregulation) leading to decrease of antioxidant genes expression in non-metabolic organs such as kidneys and lungs during aging. These phenomena are reversed by CR. The results of studies on the process of aging and CR indicate that the Akt/FoxOs axis plays a critical role in regulating metabolic homeostasis, redox stress, and inflammation in various organs during aging process. The benefical actions of CR on the Akt/FoxOs axis in metabolic and non-metabolic organs provide further insights into the molecular mechanisms of organ-differential roles of Akt/FoxOs axis during aging.

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Section: Differential Roles Of Akt/foxos Axis In Metabolic- and Non-metabolic Organsmentioning

confidence: 99%