Smokers can learn to influence their urge to smoke

Dols, M.; Willems, Brecht A. G.; Hout, Marcel van den; Bittoun, Renee

doi:10.1016/s0306-4603(98)00115-4

Cited by 70 publications

(81 citation statements)

References 4 publications

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“…Research has also demonstrated that contextual cues (i.e. cues that indicate smoking availability) can increase cravings for smoking [38,37,170,169]. Consistent with these data, research in mice has demonstrated that nicotine alters contextual learning.…”

Section: Nicotinic Acetylcholine Receptors: Animal Researchmentioning

confidence: 75%

“…In addition to changes in reward, evidence from both human and animal research has demonstrated that nicotine alters cognitive processes, including associative learning [35,37,48,58,88]. For example, cravings for nicotine were increased following the presentation of previously neutral environmental cues that were associated with smoking [88].…”

Section: Nicotinic Acetylcholine Receptors: Animal Researchmentioning

confidence: 99%

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Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research

Portugal

Gould

2008

Behavioural Brain Research

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Tobacco smoking is a leading preventable cause of death in the United States and produces a major health and economic burden. Although the majority of smokers want to quit, few are successful. These data highlight the need for additional research into the neurobiology of tobacco dependence. Addiction to nicotine, the main psychoactive component of tobacco, is influenced by multiple factors that include individual differences in genetic makeup. Twin studies have demonstrated that genetic factors can influence vulnerability to nicotine addiction, and subsequent research has identified genes that may alter sensitivity to nicotine. In humans, genome-wide and candidate gene association studies have demonstrated that genes encoding nicotinic acetylcholine receptor (nAChR) proteins are associated with multiple smoking phenotypes. Similarly, research in mice has provided evidence that naturally occurring variability in nAChR genes is associated with changes in nicotine sensitivity. Furthermore, the use of genetic knockout mice has allowed researchers to determine the nAChR genes that mediate the effects of nicotine, whereas research with knockin mice has demonstrated that changes to nAChR genes can dramatically alter nicotine sensitivity. This review will examine the genetic factors that alter susceptibility to nicotine addiction, with an emphasis on the genes that encode nAChR proteins.

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Section: Nicotinic Acetylcholine Receptors: Animal Researchmentioning

confidence: 75%

Section: Nicotinic Acetylcholine Receptors: Animal Researchmentioning

confidence: 99%

Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research

Portugal

Gould

2008

Behavioural Brain Research

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“…External and sensory conditioned cues may play a critical role in tobacco addiction (Balfour et al, 2000;Caggiula et al, 2001) and, more specifically, in the maintenance of nicotine-taking behavior (Brauer et al, 2001). Consequently, stimuli associated with smoking or nicotine produce craving and support smoking behavior in humans (Mucha et al, 1999;Dols et al, 2000). Similarly, preclinical experiments have also indicated an important role of nicotine-associated CS in nicotine-seeking and nicotine-taking behavior, and this relation has been demonstrated in the nicotine selfadministration paradigm where such stimuli support instrumental behavior even in the absence of nicotine (Caggiula et al, 2001).…”

Section: Introductionmentioning

confidence: 96%

Repeated Nicotine Exposure Enhances Reward-Related Learning in the Rat

Olausson

Jentsch

Taylor

2003

Neuropsychopharmacol

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Repeated exposure to addictive drugs causes neuroadaptive changes in cortico-limbic-striatal circuits that may underlie alterations in incentive-motivational processes and reward-related learning. Such drug-induced alterations may be relevant to drug addiction because enhanced incentive motivation and increased control over behavior by drug-associated stimuli may contribute to aspects of compulsive drug-seeking and drug-taking behaviors. This study investigated the consequences of repeated nicotine treatment on the acquisition and performance of Pavlovian discriminative approach behavior, a measure of reward-related learning, in male rats. Water-restricted rats were trained to associate a compound conditioned stimulus (tone+light) with the availability of water (the unconditioned stimulus) in 15 consecutive daily sessions. In separate experiments, rats were repeatedly treated with nicotine (0.35 mg/kg, s.c.) either (1) prior to the onset of training, (2) after each daily training session was completed (ie postsession injections), or (3) received nicotine both before the onset of training as well as after each daily training session. In this study, all nicotine treatment schedules increased Pavlovian discriminative approach behavior and, thus, prior repeated exposure to nicotine, repeated postsession nicotine injections, or both, facilitated rewardrelated learning.

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“…Studies of smokers in both laboratory and naturalistic environments have confirmed a positive relationship between exposure to smoking cues and measurable changes in subjective and physiological responses (e.g., Baumann & Sayette, 2006;Bordnick, et al, 2005;Dols, Willems, van den Hout, & Bittoun, 2000;Harakeh, Engels, van Baaren, & Scholte, 2007). With this in mind, it was decided that the second laboratory activity would be a presentation of short film clips shown in an enhanced media environment (i.e.…”

Section: Task 4: Development Of Mediated Intervention Materials (12 Wmentioning

confidence: 99%

Transformative Learning: Patterns of Psychophysiologic Response and Technology-Enabled Learning and Intervention Systems

Jerome¹,

Jordan²,

Rodericks³

2008

PsycEXTRA Dataset

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Smokers can learn to influence their urge to smoke

Cited by 70 publications

References 4 publications

Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research

Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research

Repeated Nicotine Exposure Enhances Reward-Related Learning in the Rat

Transformative Learning: Patterns of Psychophysiologic Response and Technology-Enabled Learning and Intervention Systems

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