Smoke exposure, wheezing, and asthma development: A systematic review and meta‐analysis in unselected birth cohorts

Silvestri, Michela; Franchi, Sara; Pistorio, Angela; Petecchia, Loredana; Rusconi, Franca

doi:10.1002/ppul.23037

Cited by 125 publications

(109 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This analysis found a 36% increased risk of wheezing in early life of infants whose mothers smoked during pregnancy, while no clear exclusive postnatal effect could be demonstrated [64]. While maternal smoking and exposure increase the risk of asthma development, in nonsmoking mothers antenatal maternal ETS exposure also increased the risk of asthma development in their children [65].…”

Section: Resultsmentioning

confidence: 99%

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Vanker

Gie

Zar

2017

Expert Review of Respiratory Medicine

136

View full text Add to dashboard Cite

Introduction: Childhood respiratory illness is a major cause of morbidity and mortality particularly in low and middle-income countries. Environmental tobacco smoke (ETS) exposure is a recognised risk factor for both acute and chronic respiratory illness.Areas covered: The aim of this paper was to review the epidemiology of ETS exposure and impact on respiratory health in children. We conducted a search of 3 electronic databases of publications on ETS and childhood respiratory illness from 1990–2015. Key findings were that up to 70% of children are exposed to ETS globally, but under-reporting may mask the true prevalence. Maternal smoking and ETS exposure influence infant lung development and are associated with childhood upper and lower respiratory tract infection, wheezing or asthma. Further, exposure to ETS is associated with more severe respiratory disease. ETS exposure reduces lung function early in life, establishing an increased lifelong risk of poor lung health.Expert commentary: Urgent and effective strategies are needed to decrease ETS exposure in young children to improve child and long-term lung health in adults especially in low and middle income countries where ETS exposure is increasing.

show abstract

Section: Resultsmentioning

confidence: 99%

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Vanker

Gie

Zar

2017

Expert Review of Respiratory Medicine

136

View full text Add to dashboard Cite

show abstract

“…One of the well-known risk factors implicated in the development of wheezing and an associated diminished lung function is maternal smoking during pregnancy [2,3]. The role of other prenatal exposures, including pregnancy complications or air pollution exposure, is less clear [4].…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to antibiotics and wheezing in infancy: a birth cohort study

et al. 2015

Self Cite

View full text Add to dashboard Cite

The role of prenatal antibiotic exposure in the development of childhood wheezing is debated. We evaluated whether this association could potentially be explained by confounding factors.Antibiotic use in the first and third trimester of pregnancy, wheezing in children aged ⩽18 months and confounding factors were assessed in singletons participating in the NINFEA (Nascita e Infanzia: gli Effetti dell'Ambiente) birth cohort (n=3530 for first-trimester exposure and n=3985 for third-trimester exposure).There was no evidence of an association between antibiotic exposure in the first trimester of pregnancy and ever-wheezing (adjusted risk ratio (RR) 1.02, 95% CI 0.80-1.30) or recurrent wheezing (RR 0.99, 95% CI 0.54-1.82). For the third-trimester exposure, the crude RRs (95% CI) of ever-wheezing and recurrent wheezing were 1.34 (1.10-1.64) and 2.72 (1.80-4.11), respectively, which decreased to 1.12 (0.90-1.39) and 2.09 (1.32-3.29) after adjustment. The RRs of wheezing after genitourinary infections during pregnancy were increased independently of antibiotic treatment.In conclusion, the association between prenatal antibiotic exposure and infant wheezing could be largely explained by confounding factors, in particular respiratory infections during pregnancy. An excess risk of wheezing after antibiotic exposure during the third trimester of pregnancy remains after adjustment. @ERSpublications Confounders explain increased risk of infant wheeze after antibiotic exposure in the first but not third trimester

show abstract

“…Our data revealing the high percentage of active smokers among asthma patients imply that asthma should also be considered for these patients in differential diagnosis. In addition to this, second-hand smoke is a particular problem for people with asthma, as it directly triggers asthma episodes and increases airway responsiveness to irritants and allergens (21). As the most common trigger factor is air pollution in our study (65.4% and 60.7% for asthma and COPD, respectively), efforts to control environmental air pollution are also essential to help minimizing the exacerbation risk especially in asthma patients (22).…”

Section: Discussionmentioning

confidence: 99%

Real life profile of asthma and chronic obstructive pulmonary disease patients in Turkey

et al. 2017

View full text Add to dashboard Cite

Smoke exposure, wheezing, and asthma development: A systematic review and meta‐analysis in unselected birth cohorts

Cited by 125 publications

References 56 publications

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Prenatal exposure to antibiotics and wheezing in infancy: a birth cohort study

Real life profile of asthma and chronic obstructive pulmonary disease patients in Turkey

Contact Info

Product

Resources

About