Smears are important for adequate cytologic diagnosis of kidney lesions

Chen, Athena L.; Brown, Peter; Sweeney, Brenda; Feldman, Adam S.; Arellano, Ronald S.; Tambouret, Rosemary

doi:10.1016/j.jasc.2017.05.001

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…The diagnostic yield of HP alone in our study was 88.1%, and that of HP plus LBC was 94.0%, which is comparable with the results from a meta-analysis that reported an overall diagnostic rate of 92% ( 11 ). There is some evidence that FNA is a complementary technique to CNB in renal masses ( 12 ), especially in necrotic lesions ( 13 ). Meanwhile, it has also been highlighted that the added value combined CNB and FNA should be weighed against time, complications, healthcare cost, and resources ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Sequential liquid-based cytology based on exfoliative cells of 18-gauge core needle groove to improve renal mass core needle biopsy yield: a real-world observational study

Han,

Yang,

Wang

et al. 2023

Quant Imaging Med Surg

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Background Renal mass biopsy (RMB) has regained clinical interest in recent years due to the pursuit of individualized and precision medicine. Renal mass core needle biopsy (RMCNB) for histopathology (HP), with or without liquid-based cytology (LBC), has been used increasingly in our hospital. This study investigated factors influencing the HP diagnostic yield of RMCNB, and compared the diagnostic rate between HP alone and HP plus LBC. Methods In this retrospective cross-sectional study, a total of 134 patients who underwent ultrasound-guided percutaneous RMCNB in the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College between January 2015 and May 2022 were enrolled. All biopsies were performed using an 18-gauge core needle biopsy gun, and the sampling tissues and exfoliative cells of 18-gauge core needle groove were delivered for HP and LBC diagnosis, respectively. The patient demographics, clinical indications, tumor characteristics, number of biopsies, final pathological diagnosis, and follow-up data were reviewed. Univariate and multivariate logistic regression analyses were performed to evaluate the association between variables and HP diagnostic yield of RMCNB. The diagnostic rate between HP and HP plus LBC was compared using McNemar’s test and agreement was evaluated using the Kappa score. Results The most common indication of RMCNB was renal masses with a radiological diagnosis of locally advanced disease or distant metastasis (86.6%). The HP diagnostic yield was established in 88.1% (118/134) of cases, and the diagnostic rate of HP plus LBC was 94.0% (126/134). Logistic regression analyses revealed that non-enhanced area exceeding 50% [odds ratio (OR): 0.021, 95% confidence interval (CI): 0.003–0.134, P<0.001] and number of core biopsies (OR: 9.479, 95% CI: 1.528–58.794, P=0.016) were associated with the HP diagnostic yield of RMCNB. The diagnostic rate of HP plus LBC was significantly higher than that of HP alone (94.0% vs. 88.1%, P=0.008), and they showed substantial agreement (Kappa =0.638, P<0.001). Meanwhile, in the non-enhanced area ≥50% subgroup, the diagnostic rate between HP plus LBC and HP alone was significantly different (86.7% vs. 60%, P=0.008), and the agreement was fair (Kappa =0.375, P=0.009). Conclusions RMCNB has a high diagnostic yield with a minimum of two high-quality core biopsies, LBC can improve the diagnostic yield of HP alone, especially in masses with large non-enhanced area.

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Section: Discussionmentioning

confidence: 99%

Sequential liquid-based cytology based on exfoliative cells of 18-gauge core needle groove to improve renal mass core needle biopsy yield: a real-world observational study

Han,

Yang,

Wang

et al. 2023

Quant Imaging Med Surg

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Current Management of Small Renal Masses, Including Patient Selection, Renal Tumor Biopsy, Active Surveillance, and Thermal Ablation

Sánchez

Feldman

Hakimi³

2018

JCO

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111

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Renal cancer represents 2% to 3% of all cancers, and its incidence is rising. The increased use of ultrasonography and cross-sectional imaging has resulted in the clinical dilemma of incidentally detected small renal masses (SRMs). SRMs represent a heterogeneous group of tumors that span the full spectrum of metastatic potential, including benign, indolent, and more aggressive tumors. Currently, no composite model or biomarker exists that accurately predicts the diagnosis of kidney cancer before treatment selection, and the use of renal mass biopsy remains controversial. The management of SRMs has changed dramatically over the last two decades as our understanding of tumor biology and competing risks of mortality in this population has improved. In this review, we critically assess published consensus guidelines and recent literature on the diagnosis and management of SRMs, with a focus on patient treatment selection and use of renal mass biopsy, active surveillance, and thermal ablation. Finally, we highlight important opportunities for leveraging recent research discoveries to identify patients with SRMs at high risk for renal cell carcinoma–related mortality and minimize overtreatment and patient morbidity.

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Localized Renal Masses: Comment on Recent American Urological Association Guideline

Fatheree

Fitzgibbons

Rao

et al. 2019

Archives of Pathology &Amp; Laboratory Medicine

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Smears are important for adequate cytologic diagnosis of kidney lesions

Cited by 3 publications

References 22 publications

Sequential liquid-based cytology based on exfoliative cells of 18-gauge core needle groove to improve renal mass core needle biopsy yield: a real-world observational study

Sequential liquid-based cytology based on exfoliative cells of 18-gauge core needle groove to improve renal mass core needle biopsy yield: a real-world observational study

Current Management of Small Renal Masses, Including Patient Selection, Renal Tumor Biopsy, Active Surveillance, and Thermal Ablation

Localized Renal Masses: Comment on Recent American Urological Association Guideline

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