Smartphone-Based Pupillometer with Chromatic Stimuli to Screen Neuro-Ophthalmological Diseases

Sousa, Ana Isabel; Marques-Neves, Carlos; Vieira, Pedro

doi:10.1007/978-3-030-92328-0_19

Cited by 2 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This environment light was chosen to be red coloured, as per previous findings [ 21 ], with the main function of illuminating the individual’s eye and allowing good quality of the recorded image. A red coloured environment light, with a wavelength of 625 ± 5, is opposite to the ipRGCs peak sensitivity at around 482 nm [ 6 , 8 , 9 ] in the visible light spectrum, so it would not stimulate the ipRGCs neither impact their sustained pupillary response after stimulus.…”

Section: Methodsmentioning

confidence: 99%

“…The protocol followed is based on previous works [ 18 , 20 , 21 , 26 ] and is represented in a schema in Figure 3 . Initially, the individual was in a dark room for 7 min, with just the red environment light switched on.…”

Section: Methodsmentioning

confidence: 99%

“…Smartphones, an accessible and easy-to-use technology, could have high interest as a solution to spread this technique and make it affordable and reachable. Some research has been presented over the last ten years for pupillometry using a smartphone [ 19 , 20 , 21 , 22 ]. In 2022, our group presented a preliminary study for chromatic pupillometry using a smartphone [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Some research has been presented over the last ten years for pupillometry using a smartphone [ 19 , 20 , 21 , 22 ]. In 2022, our group presented a preliminary study for chromatic pupillometry using a smartphone [ 21 ]. This work showed good-quality records of the eye and pupil detection with the smartphone.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Development of a Smartphone-Based System for Intrinsically Photosensitive Retinal Ganglion Cells Targeted Chromatic Pupillometry

Sousa,

Marques-Neves,

Vieira

2024

Bioengineering

Self Cite

View full text Add to dashboard Cite

Chromatic Pupillometry, used to assess Pupil Light Reflex (PLR) to a coloured light stimulus, has regained interest since the discovery of melanopsin in the intrinsically photosensitive Retinal Ganglion Cells (ipRGCs). This technique has shown the potential to be used as a screening tool for neuro-ophthalmological diseases; however, most of the pupillometers available are expensive and not portable, making it harder for them to be used as a widespread screening tool. In this study, we developed a smartphone-based system for chromatic pupillometry that allows targeted stimulation of the ipRGCs. Using a smartphone, this system is portable and accessible and takes advantage of the location of the ipRGCs in the perifovea. The system incorporates a 3D-printed support for the smartphone and an illumination system. Preliminary tests were carried out on a single individual and then validated on eleven healthy individuals with two different LED intensities. The average Post-Illumination Pupil Light Response 6 s after the stimuli offsets (PIPR-6s) showed a difference between the blue and the red stimuli of 9.5% for both intensities, which aligns with the studies using full-field stimulators. The results validated this system for a targeted stimulation of the ipRGCs for chromatic pupillometry, with the potential to be a portable and accessible screening tool for neuro-ophthalmological diseases.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of a Smartphone-Based System for Intrinsically Photosensitive Retinal Ganglion Cells Targeted Chromatic Pupillometry

Sousa,

Marques-Neves,

Vieira

2024

Bioengineering

Self Cite

View full text Add to dashboard Cite

show abstract

“…Using a 360° protractor application, the axis of the eye can be compared between smartphone-macro lens images before and after surgical intervention to quantify torsion of the iris and retina ( 425 , 426 ). It is possible to perform pupillometry using SI, giving smartphones additional utility in the management of neuro-ophthalmological disease ( 427 , 428 ). McAnany et al observed excellent agreement when comparing smartphone pupillometry with infrared camera pupillometry, and found significant correlations in pupillary light reflex and re-dilation size between both methods ( 429 ).…”

Section: Teleophthalmology and Smartphone Fundus Imagingmentioning

confidence: 99%

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

et al. 2022

View full text Add to dashboard Cite

The field of ophthalmic imaging has grown substantially over the last years. Massive improvements in image processing and computer hardware have allowed the emergence of multiple imaging techniques of the eye that can transform patient care. The purpose of this review is to describe the most recent advances in eye imaging and explain how new technologies and imaging methods can be utilized in a clinical setting. The introduction of optical coherence tomography (OCT) was a revolution in eye imaging and has since become the standard of care for a plethora of conditions. Its most recent iterations, OCT angiography, and visible light OCT, as well as imaging modalities, such as fluorescent lifetime imaging ophthalmoscopy, would allow a more thorough evaluation of patients and provide additional information on disease processes. Toward that goal, the application of adaptive optics (AO) and full-field scanning to a variety of eye imaging techniques has further allowed the histologic study of single cells in the retina and anterior segment. Toward the goal of remote eye care and more accessible eye imaging, methods such as handheld OCT devices and imaging through smartphones, have emerged. Finally, incorporating artificial intelligence (AI) in eye images has the potential to become a new milestone for eye imaging while also contributing in social aspects of eye care.

show abstract

Smartphone-Based Pupillometer with Chromatic Stimuli to Screen Neuro-Ophthalmological Diseases

Cited by 2 publications

References 14 publications

Development of a Smartphone-Based System for Intrinsically Photosensitive Retinal Ganglion Cells Targeted Chromatic Pupillometry

Development of a Smartphone-Based System for Intrinsically Photosensitive Retinal Ganglion Cells Targeted Chromatic Pupillometry

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

Contact Info

Product

Resources

About