Smartphone based optical spectrometer for diffusive reflectance spectroscopic measurement of hemoglobin

Recent advancements in bioanalytical techniques have led to the development of novel and robust diagnostic approaches that hold promise for providing optimal patient treatment, guiding prevention programs and widening the scope of personalized medicine. However, these advanced diagnostic techniques are still complex, expensive and limited to centralized healthcare facilities or research laboratories. This significantly hinders the use of evidence-based diagnostics for resource-limited settings and the primary care, thus creating a gap between healthcare providers and patients, leaving these populations without access to precision and quality medicine. Smartphone-based imaging and sensing platforms are emerging as promising alternatives for bridging this gap and decentralizing diagnostic tests offering practical features such as portability, cost-effectiveness and connectivity. Moreover, towards simplifying and automating bioanalytical techniques, biosensors and lab-on-a-chip technologies have become essential to interface and integrate these assays, bringing together the high precision and sensitivity of diagnostic techniques with the connectivity and computational power of smartphones. Here, we provide an overview of the emerging field of clinical smartphone diagnostics and its contributing technologies, as well as their wide range of areas of application, which span from haematology to digital pathology and rapid infectious disease diagnostics.

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“…(c) A smartphone spectrometer configuration with optical fiber and micro USB interface for operation. Reprinted from . CC BY 4.0.…”

Section: Smartphone‐based Imaging Technologiesmentioning

confidence: 99%

Smartphone‐based clinical diagnostics: towards democratization of evidence‐based health care

et al. 2018

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“…Fortunately, several portable spectrometers have become commercially available due to advancements in sensor and IT technology; e.g., startup companies such as Stratio, SCiO, and TellSpec have developed pocket-sized spectrometers [1][2][3]. Several research groups recently demonstrated that a low-cost smartphone spectrometer can be designed using off-the-shelf components [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Minimizing Device-to-Device Variation in the Spectral Response of Portable Spectrometers

Choi

Kim²,

Lee³

et al. 2019

Journal of Sensors

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As portable spectrometers have been developed, the research of spectral analysis has evolved from a traditional laboratory-based closed environment to a network-connected open environment. Consequently, its application areas are expanding in combination with machine learning techniques. The device-to-device variation in the spectral response of portable spectrometers is a critical issue in a machine learning-based service scenario since the classification performance is highly dependent on the consistency of spectral responses from each spectrometer. To minimize device-to-device variation, a cuboid prism is employed instead of a combination of mirrors and prism to construct an optical system for the spectrometer. The spectral responses are calibrated to correct pixel shift on the image sensor. Experimental results show that the proposed method can minimize the device-to-device variation in spectral response of portable spectrometers.

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“…It has been demonstrated recently that incorporation of advanced optical systems into smartphone platforms is a useful development [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. In our previous work, we developed a digital camera-based portable imaging spectrometer to detect reflectance spectra from the ocean, a lake, and a human hand [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental Demonstration of Remote and Compact Imaging Spectrometer Based on Mobile Devices

Chen

Cai

et al. 2018

Sensors

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Imaging spectrometers show great potential for environmental and biomedical sensing applications. Selfie sticks, which are tools used to take photographs or videos, have gained global popularity in recent years. Few people have connected these two objects, and few people have researched the application of imaging spectrometers to perform scientific monitoring in point-of-use scenarios. In this paper, we develop a compact imaging spectrometer (35 g in weight, 18 mm in diameter, and 72 mm in length) that can be equipped on a motorized selfie stick to perform remote sensing. We applied this system to perform environmental and facial remote sensing via motorized scanning. The absorption of chlorophyll and hemoglobin can be found in the reflectance spectra, indicating that our system can be used in urban greening monitoring and point-of-care testing. In addition, this compact imaging spectrometer was also easily attached to an underwater dome port and a quad-rotor unmanned aerial vehicle to perform underwater and airborne spectral detection. Our system offers a route toward mobile imaging spectrometers used in daily life.

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Smartphone based optical spectrometer for diffusive reflectance spectroscopic measurement of hemoglobin

Cited by 84 publications

References 38 publications

Smartphone‐based clinical diagnostics: towards democratization of evidence‐based health care

Smartphone‐based clinical diagnostics: towards democratization of evidence‐based health care

Minimizing Device-to-Device Variation in the Spectral Response of Portable Spectrometers

Experimental Demonstration of Remote and Compact Imaging Spectrometer Based on Mobile Devices

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