Smartphone-based integrated voltammetry system for simultaneous detection of ascorbic acid, dopamine, and uric acid with graphene and gold nanoparticles modified screen-printed electrodes

Ji, Daizong; Liu, Zixiang; Liu, Lei; Low, Sze Shin; Lu, Yanli; Yu, Xiongjie; Zhu, Long; Li, Candong; Liu, Qingjun

doi:10.1016/j.bios.2018.07.074

Cited by 174 publications

(64 citation statements)

References 37 publications

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“…As a rule, an electrode modified, in one way or another, serves as a sensor. Currently, carbon materials are widely used in sensor technologies: graphene [13], graphene oxide [14,15], carbon nanotubes [16] to increase the sensor surface, its electrical conductivity and catalytic activity. Unique properties (catalytic, electronic, magnetic, high surface to volume ratio) make nanoparticles highly effective components of sensors [17].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensor Based on a Carbon Veil Modified by Phytosynthesized Gold Nanoparticles for Determination of Ascorbic Acid

Брайнина

Bukharinova

Stozhko

et al. 2020

Sensors

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An original voltammetric sensor (Au-gr/CVE) based on a carbon veil (CV) and phytosynthesized gold nanoparticles (Au-gr) was developed for ascorbic acid (AA) determination. Extract from strawberry leaves was used as source of antioxidants (reducers) for Au-gr phytosynthesis. The sensor was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy and electrochemical methods. Optimal parameters of AA determination were chosen. The sensor exhibits a linear response to AA in a wide concentration range (1 μM–5.75 mM) and a limit of detection of 0.05 μM. The developed sensor demonstrated a high intra-day repeatability of 1 μM AA response (RSD = 1.4%) and its stability during six weeks, selectivity of AA determination toward glucose, sucrose, fructose, citric, tartaric and malic acids. The proposed sensor based on Au-gr provides a higher sensitivity and a lower limit of AA detection in comparison with the sensor based on gold nanoparticles synthesized by the Turkevich method. The sensor was successfully applied for the determination of AA content in fruit juices without samples preparation. The recovery of 99%–111% and RSD no more than 6.8% confirm the good reproducibility of the juice analysis results. A good agreement with the potentiometric titration data was obtained. A correlation (r = 0.9867) between the results of AA determination obtained on the developed sensor and integral antioxidant activity of fruit juices was observed.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Sensor Based on a Carbon Veil Modified by Phytosynthesized Gold Nanoparticles for Determination of Ascorbic Acid

Брайнина

Bukharinova

Stozhko

et al. 2020

Sensors

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“…The merits of smartphones brought new possibilities for biomedical and biosensor research. Recently, many studies on smartphone-controlled platforms at the point of care (POC) have been published and several electrochemical methods have been combined with smartphone for quantitative electrochemical detections, such as chronoamperometry (CA), cyclic voltammetry (CV), differential pulse voltammetry (DPV) [13,14] and electrochemical impedance spectroscopy (EIS) [14][15][16][17]. Among them, DPV is capable of detection of low-level concentrations of analytes.…”

Section: Introductionmentioning

confidence: 99%

Salivary Cortisol Determination on Smartphone-Based Differential Pulse Voltammetry System

Liu

Men

et al. 2020

Sensors

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Cortisol is commonly used as a significant biomarker of psychological or physical stress. With the accelerated pace of life, non-invasive cortisol detection at the point of care (POC) is in high demand for personal health monitoring. In this paper, an ultrasensitive immunosensor using gold nanoparticles/molybdenum disulfide/gold nanoparticles (AuNPs/MoS2/AuNPs) as transducer was explored for non-invasive salivary cortisol monitoring at POC with the miniaturized differential pulse voltammetry (DPV) system based on a smartphone. Covalent binding of cortisol antibody (CORT-Ab) onto the AuNPs/MoS2/AuNPs transducer was achieved through the self-assembled monolayer of specially designed polyethylene glycol (PEG, SH-PEG-COOH). Non-specific binding was avoided by passivating the surface with ethanolamine. The miniaturized portable DPV system was utilized for human salivary cortisol detection. A series current response of different cortisol concentrations decreased and exhibited a linear range of 0.5–200 nM, the detection limit of 0.11 nM, and high sensitivity of 30 μA M−1 with a regression coefficient of 0.9947. Cortisol was also distinguished successfully from the other substances in saliva. The recovery ratio of spiked human salivary cortisol and the variation of salivary cortisol level during one day indicated the practicability of the immunosensor based on the portable system. The results demonstrated the excellent performance of the smartphone-based immunosensor system and its great potential application for non-invasive human salivary cortisol detection at POC.

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“…Several studies are reported on sensitive detection of dopamine using various electrode materials. [18][19][20][21] Improved selectivity is often achieved using thin films or composites of permselective polymers like Nafion [22][23][24] and various functionalized carbon nanomaterials. 11,13,15,25 However, to the best of the authors' knowledge, none of these studies have demonstrated both selectivity and sensitivity towards nanomolar levels of dopamine in the presence of physiologically relevant concentrations of anionic interferents in cyclic voltammetry measurements.…”

Section: Introductionmentioning

confidence: 99%

Multiwalled Carbon Nanotubes/Nanofibrillar Cellulose/Nafion Composite-Modified Tetrahedral Amorphous Carbon Electrodes for Selective Dopamine Detection

et al. 2019

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Vasuki Durairaj) 2 ABSTRACT: We introduce a composite membrane comprising of multi-walled carbon nanotubes (MWCNTs) dispersed in a matrix of sulfated nanofibrillar cellulose (SNFC) and Nafion. The high negative charge densities of the SNFC and Nafion ionomers enhance the cationic selectivity of the composite. The composite is characterized by scanning electron (SEM) and transmission electron (TEM) microscopies as well as Fourier transform infrared (FTIR) and Raman spectroscopies. Tetrahedral amorphous carbon (ta-C) electrodes modified with the composite are investigated as potential dopamine (DA) electrochemical sensors. The composite-modified electrodes show significant selectivity and sensitivity towards DA in the presence of ascorbic acid (AA) and uric acid (UA) in physiologically relevant concentrations. A linear dopamine detection range of 0.05 -100 µM with detection limits of 65 nM in PBS and 107 nM in interferent solution was determined using 100 mV/s cyclic voltammetry (CV) measurements. These results highlight the potential of the composite membrane for in vivo detection of neurotransmitters.

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Smartphone-based integrated voltammetry system for simultaneous detection of ascorbic acid, dopamine, and uric acid with graphene and gold nanoparticles modified screen-printed electrodes

Cited by 174 publications

References 37 publications

Electrochemical Sensor Based on a Carbon Veil Modified by Phytosynthesized Gold Nanoparticles for Determination of Ascorbic Acid

Electrochemical Sensor Based on a Carbon Veil Modified by Phytosynthesized Gold Nanoparticles for Determination of Ascorbic Acid

Salivary Cortisol Determination on Smartphone-Based Differential Pulse Voltammetry System

Multiwalled Carbon Nanotubes/Nanofibrillar Cellulose/Nafion Composite-Modified Tetrahedral Amorphous Carbon Electrodes for Selective Dopamine Detection

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