Smartphone-based dynamic measurements of electro-optically modulated lossy-mode resonance and its biosensing applications

Pituła, Emil; Janik, Monika; Sezemsky, Petr; Szymańska, Katarzyna; Olszewski, Marcin; Straňák, Vítězslav; Koba, Marcin; Śmietana, Mateusz

doi:10.1016/j.measurement.2022.112349

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…Due to the optimized thickness and optical properties of the film, LMR could be observed in the optical domain, while the electrical properties of ITO/FTO allow to apply the sensor as a working electrode in an EC setup. It has been confirmed that the LMR response depends on both E applied to the electrode as well as the optical properties of the external medium [1][2][3] . When considering optical labelfree biosensing, the properties of the target biological materials include mainly its RI, uniformity of its distribution on the surface, and the size/thickness of formed layer.…”

Section: Introductionmentioning

confidence: 74%

“…There are additional factors which have not been addressed till now, such as those related to the disturbed distribution of charge carriers at the sensor surface. Such change usually is followed by further modulation of optical properties of the sensor, i.e., n and imaginary part of the RI (k) of the material, and therefore, in many cases, need to be concerned 1,2 . These apply to the optical sensors consisting of both conductive and non-conductive materials, where the distribution of the carriers may be disturbed.…”

Section: Introductionmentioning

confidence: 99%

“…This, in turn, determines both electrochemical as well as optical properties of the film. The mechanism of electro-optical modulation was described in 1,2 . As an example of multi-domain sensing concept we can consider lossy-mode resonance (LMR) supported by conductive layers such as ITO or FTO.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does the refractive index sensitivity matter the most? Charge of biological material and performance of label-free biosensors

Janik

Niedziałkowski

Lechowicz

et al. 2023

European Workshop on Optical Fibre Sensors (EWOFS 2023)

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The work discusses the possible impact of the electric charge of biological material on the properties of label-free biosensors, in particular those operating in dual domains, i.e., optical and electrochemical. Optical fiber lossy-mode resonance (LMR) sensors based on indium tin oxide (ITO) were investigated as label-free biosensors with a model biological receptor-target pair, i.e., biotin-avidin. Each of the used biological materials shows different properties, i.e., size, isoelectric point, and, therefore, also charge. The investigations were performed in two electrolytes with differently charged redox couples to better identify the possible influence of chargé of biological material on the optical readout. The obtained results clearly indicate that in designing label-free biosensing solutions, consideration of a broader range of biological materials properties than just refractive index, such as their charge, is required.

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Section: Introductionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Does the refractive index sensitivity matter the most? Charge of biological material and performance of label-free biosensors

Janik

Niedziałkowski

Lechowicz

et al. 2023

European Workshop on Optical Fibre Sensors (EWOFS 2023)

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“…LSPR sensors can also be integrated with optical fibers [132,133]. In fact, fibers can be used for index sensing themselves using their own optical modes, such as the lossymode resonance (LMR)-based sensing technique [134][135][136][137][138]. The integration of LSPR can improve the sensitivity of the fiber-based sensors and further enable the combination of the SERS technique.…”

Section: Refractive Index Sensingmentioning

confidence: 99%

Chemical Sensing and Analysis with Optical Nanostructures

Dong,

Wang,

Zhao

et al. 2023

Chemosensors

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Nanostructures and nanomaterials, especially plasmonic nanostructures, often show optical properties that conventional materials lack and can manipulate light, as well as various light–matter interactions, in both their near-field and far-field regions with a high efficiency. Thanks to these unique properties, not only can they be used to enhance the sensitivity of chemical sensing and analysis techniques, but they also provide a solution for designing new sensing devices and simplifying the design of analytical instruments. The earliest applications of optical nanostructures are surface-enhanced spectroscopies. With the help of the resonance field enhancement of plasmonic nanostructures, molecular signals, such as Raman, infrared absorption, and fluorescence can be significantly enhanced, and even single-molecule analysis can be realized. Moreover, the resonant field enhancements of plasmonic nanostructures are often associated with other effects, such as optical forces, resonance shifts, and photothermal effects. Using these properties, label-free plasmonic sensors, nano-optical tweezers, and plasmonic matrix-assisted laser desorption/ionization have also been demonstrated in the past two decades. In the last few years, the research on optical nanostructures has gradually expanded to non-periodic 2D array structures, namely metasurfaces. With the help of metasurfaces, light can be arbitrarily manipulated, leading to many new possibilities for developing miniaturized integrated intelligent sensing and analysis systems. In this review, we discuss the applications of optical nanostructures in chemical sensing and analysis from both theoretical and practical aspects, aiming at a concise and unified framework for this field.

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“…Electro-optical sensors are also considered for label-free sensing applications, especially in biosensing. ,− However, to date, no detailed study has been conducted concerning the impact of a layer formation on the thin film’s surface on the sensor’s performance in both domains. It is known that growth of a biological or chemical layer disturbs electrode–electrolyte charge transfer in the EC domain. , The forming layer also changes the distribution of the electromagnetic field and guiding conditions for lossy modes in the optical domain.…”

Section: Introductionmentioning

confidence: 99%

Electro-Optically Modulated Lossy-Mode Resonance─A New Approach for Label-Free Sensing

Śmietana,

Burnat,

Curda

et al. 2024

ACS Photonics

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In this work, we report studies on the impact of thin dielectric layer formation on the optical, electrochemical, and electro-optically modulated responses of an indium tin oxide (ITO)-coated optical fiber sensor. The properties of ITO, such as optical transparency, high refractive index, and electrochemical activity, make it possible to obtain a lossy-mode resonance (LMR) effect in the optical domain and simultaneously use the sensor as an electrode in the electrochemical domain. The dielectric layer has been obtained on the ITO surface with precision down to a single nanometer using the atomic layer deposition (ALD) method. It is considered a reference to forming a biological or chemical layer during label-free sensing applications of such dual-domain sensors. It has been found that the sensor responds in both optical and electrochemical domains to the formation of a coating on the ITO surface. Numerical and experimental studies have proven that there is also a strong impact of the dielectric layer on the electro-optical modulation effectiveness. Changes in ITO's refractive index and extinction coefficient at its interface with the layer are induced by the modulation of free charge carriers' density. It has been shown that changes in the thickness of the dielectric layer, down to tenths of nanometers, can be precisely monitored when modulation is applied. Such an attribute is hardly possible when standard optical measurements, i.e., without modulation are considered. The findings open new opportunities for using electro-optical modulation in label-free sensing and biosensing, especially when small biological species or their low concentrations are targeted.

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Smartphone-based dynamic measurements of electro-optically modulated lossy-mode resonance and its biosensing applications

Cited by 5 publications

References 32 publications

Does the refractive index sensitivity matter the most? Charge of biological material and performance of label-free biosensors

Does the refractive index sensitivity matter the most? Charge of biological material and performance of label-free biosensors

Chemical Sensing and Analysis with Optical Nanostructures

Electro-Optically Modulated Lossy-Mode Resonance─A New Approach for Label-Free Sensing

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