Smartphone-based clinical diagnostics

Zhang, Shengwei; Tis, Taleb Ba; Wei, Qingshan

doi:10.1016/b978-0-12-819178-1.00048-4

“…Smartphones, as controllers, processors, and detectors, are alternatives for laboratory-based equipment due to their high-resolution camera, great computing ability and easy operation software. 22–24 In general, smartphone cameras capture photographs and translate them into various color spaces, such as red, green, blue (RGB), hue, saturation, value (HSV) and grayscale, for quantitative analysis. Integrating optical assays (colorimetric, fluorometric and chemiluminescence methods), smartphones, as instrument-free analytical devices, have been applied in medical diagnosis, food safety and environmental monitoring fields.…”

Section: Introductionmentioning

confidence: 99%

Integrating smartphone-assisted ratiometric fluorescent sensors with in situ hydrogel extraction for visual detection of organophosphorus pesticides

Tong

¹

,

Cai

²

,

Zhu

³

et al. 2022

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“…Because they are portable, ubiquitous and also produce rapid and simple quantitative results that can be interpreted by untrained personnel especially in resource-limited areas [14,[20][21][22][23]. To-date, one research teams have been reported smartphone platform for POC quanti cation of VB12 in blood using immonuassay-based lateral ow biosensors [24].…”

Section: Introductionmentioning

confidence: 99%

Nicotinamide-Functionalized Carbon Quantum Dot as New Sensing Platform for Portable Quantification of Vitamin B12 in Fluorescence, UV–Vis and Smartphone Triple Mode

Dadkhah

¹

,

Mehdinia

²

,

Jabbari

³

et al. 2022

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Development of an e cient, portable and simple nanosensor-based systems with reliable analytical performance for on-site monitoring of vitamin B12 (VB12) are still major problems and a challenging work for quality control of manufacturers. Herein, a new uorescence, UV-Vis and smartphone triple mode nanosensors were designed for the simultaneous detection of VB12 with high sensitivity and accuracy. A novel nanosensor was synthesized through nicotinamide-functionalizing on carbon quantum dot (NA-CQDs) by an one-step microwave-assisted method with green approaches. The NA-CQDs as new nanosensor showed excellent uorescence properties and wide linear ranges from 0.1-60 µM with the detection limits of 31.7 nM. Moreover, color changes of NA-CQDs induced by the VB12 could also be detected by UV-Vis spectrophotometer and inhouse-developed application installed on smartphone as a signal reader, simultanusly. The Red, Green and Blue (RGB) intensities of the colorimetric images of NA-CQDs/VB12 system which taken by smartphone's camera converted into quantitative values by the introduced application. A smartphone-integrated with NA-CQDs as colorimetric sensing platform displays good linear ranges (4.16 to 66.6 µM) for on-site determination of VB12 with detection limit of 1.40 µM.The method was successfully applied in the determination of VB12 in complex pharmaceutical supplement formulations without any sample pre-treatment and matrix interfering effects. The recovery results (96.52-105.10%) which are in agreement with the reference methods, demonstrating the capability of the smartphone-assisted colorimetric sensing platform in many on-site practical applications of quality controls.

show abstract

“…Because they are portable, ubiquitous and also produce rapid and simple quantitative results that can be interpreted by untrained personnel especially in resource-limited areas [14,[20][21][22][23]. To-date, one research teams have been reported smartphone platform for POC quanti cation of VB12 in blood using immonuassay-based lateral ow biosensors [24].…”

Section: Introductionmentioning

confidence: 99%

Nicotinamide-Functionalized Carbon Quantum Dot as New Sensing Platform for Portable Quantification of Vitamin B12 in Fluorescence, Uv-Vis and Smartphone Triple Mode

Dadkhah

¹

,

Mehdinia

²

,

Jabbari

³

et al. 2021

SSRN Journal

0

View full text Add to dashboard Cite

Development of an e cient, portable and simple nanosensor-based systems with reliable analytical performance for on-site monitoring of vitamin B12 (VB12) are still major problems and a challenging work for quality control of manufacturers. Herein, a new uorescence, UV-Vis and smartphone triple mode nanosensors were designed for the simultaneous detection of VB12 with high sensitivity and accuracy. A novel nanosensor was synthesized through nicotinamide-functionalizing on carbon quantum dot (NA-CQDs) by an one-step microwave-assisted method with green approaches. The NA-CQDs as new nanosensor showed excellent uorescence properties and wide linear ranges from 0.1-60 µM with the detection limits of 31.7 nM. Moreover, color changes of NA-CQDs induced by the VB12 could also be detected by UV-Vis spectrophotometer and inhouse-developed application installed on smartphone as a signal reader, simultanusly. The Red, Green and Blue (RGB) intensities of the colorimetric images of NA-CQDs/VB12 system which taken by smartphone's camera converted into quantitative values by the introduced application. A smartphone-integrated with NA-CQDs as colorimetric sensing platform displays good linear ranges (4.16 to 66.6 µM) for on-site determination of VB12 with detection limit of 1.40 µM.The method was successfully applied in the determination of VB12 in complex pharmaceutical supplement formulations without any sample pre-treatment and matrix interfering effects. The recovery results (96.52-105.10%) which are in agreement with the reference methods, demonstrating the capability of the smartphone-assisted colorimetric sensing platform in many on-site practical applications of quality controls.

show abstract

Smartphone-based clinical diagnostics

Cited by 7 publications

References 74 publications

Integrating smartphone-assisted ratiometric fluorescent sensors with in situ hydrogel extraction for visual detection of organophosphorus pesticides

Integrating smartphone-assisted ratiometric fluorescent sensors with in situ hydrogel extraction for visual detection of organophosphorus pesticides

Nicotinamide-Functionalized Carbon Quantum Dot as New Sensing Platform for Portable Quantification of Vitamin B12 in Fluorescence, UV–Vis and Smartphone Triple Mode

Nicotinamide-Functionalized Carbon Quantum Dot as New Sensing Platform for Portable Quantification of Vitamin B12 in Fluorescence, Uv-Vis and Smartphone Triple Mode

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