Smart Wound Scaffolds: Light‐Controlled Growth Factors Release on Tetrapodal ZnO‐Incorporated 3D‐Printed Hydrogels for Developing Smart Wound Scaffold (Adv. Funct. Mater. 22/2021)

Abstract

In article number 2007555, Leonard Siebert, Eunjung Lee, Su Ryon Shin, and co‐workers develop a 3D printed smart wound scaffold encapsulating growth factors decorated with light‐sensitive and antibacterial tetrapodal zinc oxide (t‐ZnO) microparticles for the treatment of chronic wounds. The multifunctional pro perties of the smart scaffold combined with light‐triggered angiogenic factor release, antibacterial properties, and tissue compatibility enable fast wound recovery.

Biofabricated poly (γ-glutamic acid) bio-ink reinforced with calcium silicate exhibiting superior mechanical properties and biocompatibility for bone regeneration

“… 37 Previous studies had demonstrated a favorability of micro-environments with roughness, interconnecting networks, and pores for cellular growth and differentiation. 38 Hence, hydrogels involving higher concentrations of CS, which displayed denser surface architectures, were speculated to be able to promote better osteogenesis and regeneration in comparison to other groups. 39 The degradation rates of the CS/γ-PGA-GMA were determined by assessing the pre- and post-immersion weights of the hydrogels.…”

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

“…The mechanisms of photoresponsive scaffolds mainly involve the cleavage of photosensitive chemical bonds, photo-induced isomerization, charge transfer, and photothermal effects [ 257 , 258 ]. Polymer scaffolds containing photosensitive chemical bonds (e.g., photocleavable ester bonds or photocleavable amide bonds) undergo chemical bond breaking under light irradiation, leading to the destruction of the scaffold structure and the consequent release of the drug ( Figure 4 ) [ 257 ].…”

Recent developments in stimuli‐responsive hydrogels for biomedical applications

“…To design photoresponsive hydrogels, light-sensitive nanoparticles or functional groups, such as azobenzenes, nitrobenzyl, and their derivatives, are non-covalently or covalently coupled to a polymer chain. Siebert et al [64] developed a 3D-printed hydrogel incorporating photo-responsive tetrapod zinc oxide (T-ZnO) particles to encapsulate VEGF. They demonstrated that T-ZnO could be activated by UV/visible light to release VEGF, thereby promoting cell proliferation, angiogenesis, and the anti-inflammatory response, consequently accelerating the wound healing process.…”