Smart tetrazole-based antibacterial nanoparticles as multifunctional drug carriers for cancer combination therapy

Abstract

Due to multidrug resistance of cancer tissues and immune-suppression of cancerous patients during chemotherapy in one hand and the use of tetrazole derivatives in medicine because of its anticancer, antifungal, and antiviral properties, on the other, we were encouraged to design novel smart antibacterial nanocomposites-based polymer of tetrazole as dual anticancer drug delivery systems. The structures of nanocomposites characterized by FTIR, H NMR, FESEM-EDX, and TGA analyzes and antibacterial activity of smart carriers were evaluated by determination of minimum inhibitory concentration (MIC) values against some bacteria and fungi. Then, the pH-responsive manner of both nanocomposites was proved by checking their release profiles at pH of the physiological environment (pH 7.4) and pH of tumor tissues (mildly acidic). Finally, the potential antitumoral activity of these nanocomposite systems against MCF7 cell lines was evaluated by MTT assay and cell cycle studies. The results demonstrated that the novel developed nanocomposites not only meet our expectations about simultaneous release of two anticancer drugs according to the predicted profile but also showed antibacterial and anticancer properties in vitro experimental. Moreover, it was proved that these carriers have tremendous potential in multifunctional drug delivery in cancer therapy.

Application of Light Scattering Techniques to Nanoparticle Characterization and Development

“…Zakerzadeh et al . designed silica NPs with encapsulated tetrazole, a cyclic/aromatic molecule with antimicrobial, antifungal and anticancer activity (Zakerzadeh et al, 2017 ).…”

Novel Methotrexate-Ciprofloxacin Loaded Alginate-Clay Based Nanocomposite as Anticancer and Antibacterial Co-Drug Delivery System

“…The newly developed multifunctional OLPALg and OMTALg nanocomposites have a cationic segments containing imidazolium ionic liquid segments intercalated in Laponit-RD and montmorillonite. Previous studies proved antibacterial properties of different polymeric nanocomposites with cationic blocks [28][29][30]32,54 . In order to investigate the probable antibacterial ability of prepared nanocomposites, their antibacterial tests were performed against the standard microbial strains of Pseudomonas aeruginosa (p. aeruginosa) and Escherichia coli (E. coli) ( Table 2).…”

“…There is an urgent need for the discovery of different antimicrobial agents that damage microbial membrane. Different polymers with such properties have been recently discovered [28][29][30][31][32] . Samples of these antibacterial agents developed as prospective alternatives for common antibiotics are: antimicrobial peptides (AMPs) 26 , synthetic cationic polymers 33,34 , quaternized amine containing polymers [35][36][37][38] , guanidine derivatives, polymeric guanidine salts like polyhexamethylene biguanide (PHMB( 39 , antimicrobial nanoparticles and nanoclays 40 .…”

Towards Universal Stimuli-Responsive Drug Delivery Systems: Pillar[5]arenes Synthesis and Self-Assembly into Nanocontainers with Tetrazole Polymers

“…Recently, polymer compositions based on polyvinyltetrazoles (PVTs) (Figure 1) are considered promising carriers for the formation of DDSs [26][27][28][29]. Polymers based on PVTs are easily synthesized, have a pronounced anti-inflammatory activity, promote blood clotting, accelerate wound healing [30,31].…”

“…14,18,23,26,28,31,32,35-Deca-(4-methylbenzylsulfonate-1-ethoxy)-pillar[5]arene(6). Light yellow crystalline substance.…”