Smart stimuli-responsive drug delivery systems in spotlight of COVID-19

Najjari, Zeinab; Sadri, Farzaneh; Varshosaz, Jaleh

doi:10.1016/j.ajps.2023.100873

Cited by 2 publications

(1 citation statement)

References 210 publications

(200 reference statements)

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“…With an increasing focus on addressing human health needs, the demands for drug release are escalating. Controlled drug-delivery systems have become crucial in biomedicine for their ability to regulate release rate and target specific sites, thus improving drug efficacy and safety, mitigating adverse reactions, and enhancing patient compliance and comfort. − Nonetheless, the selection of appropriate materials and their synthesis are critical steps in the design of drug delivery systems. , Commercially available drug carriers, including liposomes, polymer micelles, lipid nanoparticles, and hydrogels, suffer from low drug loading capacity limitation and the loss of drug activity before reaching the target tissue. − Moreover, their fixed release rates hinder the achievement of personalized adjustments tailored to specific patient requirements. To overcome above-mentioned problems, metal–organic frameworks (MOFs) have emerged as a promising candidate for drug delivery due to their tunable pore size for encapsulation of particular drug molecules. − Among them, adaptive MOFs exhibit great potential in achieving controlled drug release under desired conditions by selective activation under specific endogenous or exogenous stimuli.…”

Section: Introdutionmentioning

confidence: 99%

Transformation of Metal–Organic Framework from Kinetic to Thermodynamic Product for Controlled Delivery of Vitamin C

Zhang,

Lu,

Cai

et al. 2024

Inorg. Chem.

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A biocompatible metal−organic framework (MOF), named HSTC-4, constructed using the flexible 4,4′-oxybis(benzoic acid) (OBA), was developed to enable efficient loading and controlled release of vitamin C (VC) through a combination of strategies involving ligand length, structure design, and metal selection. The kinetic product HSTC-4 demonstrates a propensity for transforming into the thermodynamically stable HSTC-5 under external stimuli, such as photoillumination and vacuum heating, as witnessed by single-crystal to single-crystal transformation. Density functional theory (DFT) calculations reveal that the VC guest molecules exhibit stronger binding affinity with HSTC-5 due to its narrower pores compared to HSTC-4, resulting in a slower release of VC from VC@HSTC-5. Furthermore, precise control over VC release can be achieved by introducing surface modifications involving SiO 2 onto the structure of VC@HSCT-5, while simultaneously adjusting environmental factors such as pH and temperature conditions. Preliminary cell culture experiments and cytotoxicity assays highlight the biocompatibility of HSTC-5, suggesting that it is a promising platform for sustained drug delivery and diverse biomedical applications.

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Section: Introdutionmentioning

confidence: 99%

Transformation of Metal–Organic Framework from Kinetic to Thermodynamic Product for Controlled Delivery of Vitamin C

Zhang,

Lu,

Cai

et al. 2024

Inorg. Chem.

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Application of Nanobiomedicine in Acute Lung Injury

Lei,

Wang,

Yin

et al. 2024

j biomater tissue eng

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The respiratory system plays a crucial role in human life activities, and acute lung injury (ALI) is a highly fatal respiratory disease caused by a variety of reasons. At present, although several preclinical studies have demonstrated the efficacy of pharmacological interventions, supportive care and mechanical ventilation still remain the primary modalities for managing ALI, there are still no safe and effective treatments for ALI. With the rapid development of nanotechnology, a variety of nanobiomedicines with different structures and functional moieties have been well-designed based on their targeting ability and the pathophysiology of ALI. In this review, it summarizes the challenges faced by ALI therapy, introduces nanobiomedicines including liposomes, polymers, inorganic materials, and others to bring effective therapeutic effects for ALI, and discusses the research progress in recent years based on nanobiomedicine applied to acute lung injury. Finally, it provides a summary and prospect on the application of nanobiomedicine in ALI.

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Smart stimuli-responsive drug delivery systems in spotlight of COVID-19

Cited by 2 publications

References 210 publications

Transformation of Metal–Organic Framework from Kinetic to Thermodynamic Product for Controlled Delivery of Vitamin C

Transformation of Metal–Organic Framework from Kinetic to Thermodynamic Product for Controlled Delivery of Vitamin C

Application of Nanobiomedicine in Acute Lung Injury

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