“…To achieve our goal, we began with a desk review of the literature regarding S3, paying special attention to the aspects related to governance, inter-government coordination, innovative approaches in public intervention and S3 regional ecosystems (Marinelli and Perianez-Forte, 2017 ; Radosevic, 2017 ; Marques and Morgan, 2018 ; Larrea et al, 2019 ; Gianelle et al, 2020 ; Magro et al, 2020 ; Trippl et al, 2020 ; Guzzo and Gianelle, 2021 ; Hegyi et al, 2021 ). We supplemented this review with the literature concerning S3 in Spain which has focused on a number of aspects such as the early challenges of RIS3 in Spain (del Castillo et al, 2015 ); the validity of the RIS3 approach regarding disadvantaged regions (Madeira et al, 2021 ); the role of Universities (Pérez et al, 2017 ); and vocational education and training and RIS3 (Moso-Díez, 2020 ). Very few references were found in the recent literature, however, to multilevel governance between regional S3 strategies and the Resilience and Recovery planning process.…”