Smart Solid Drug Delivery Systems: Exploring the pH Sensitivity of Cashew Gum‑Doxorubicin Prodrug
Irisvan Ribeiro,
Adisom Leonardo,
Maria Carneiro
et al.
Abstract:Polysaccharide-based prodrugs formed via pH-responsive covalent interactions can be used to prepare nanoparticles for drug delivery to tumor cells. This study reports the synthesis of cashew gum-doxorubicin prodrugs via Schiff base (CG-S-DOX) and amide bonds (CG-A-DOX), both of which exhibit pH-responsive behavior. Synthesis was confirmed using spectroscopic techniques. Drug-binding content and efficiency were higher for CG-S-DOX than for CG-A-DOX. The capacity of the nanoparticles to self-organize in aqueous … Show more
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