Smart nanotheranostic hydrogels for on-demand cancer management

Misra, Ranjita; Acharya, Sarbari

doi:10.1016/j.drudis.2020.11.010

Cited by 17 publications

(10 citation statements)

References 105 publications

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“…Compared with conventional (no‐stimuli‐responsive) hydrogels, smart‐responsive hydrogels can achieve the effect of the controllable on‐demand release of functional molecules at the site of tissue damage 32,33 . That is more drugs or proteins are released when the body needs more and when the body needs less, fewer drugs or proteins are released 34 . In recent years, compared with conventional hydrogels, smart responsive hydrogels with various response mechanisms have attracted extensive attention in the field of tissue repair (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…32,33 That is more drugs or proteins are released when the body needs more and when the body needs less, fewer drugs or proteins are released. 34 In recent years, compared with conventional hydrogels, smart responsive hydrogels with various response mechanisms have attracted extensive attention in the field of tissue repair (Figure 1). 35 The review summarizes the current progress and advantages of smart responsive hydrogels in the field of tissue repair.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances in smart‐responsive hydrogels for tissue repairing

Yang

Wang

2022

MedComm – Biomaterials and Applications

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The rapid development of biomedical materials and tissue engineering technology has played an increasingly important role in the process of tissue repair in recent years. Smart-responsive hydrogels are three-dimensional network structures formed by cross-linking of hydrophilic polymers. In addition to having conventional hydrogels that approximate the natural extracellular matrix structure and serve as delivery vehicles for functional molecules (drugs and proteins). More importantly, smart-responsive hydrogels can achieve relevant changes in material morphology or properties under the conditions of changes in physical, chemical, and biological factors, thereby achieving controlled functional molecules release. It is more urgent to design and build smart-responsive hydrogels to achieve precise tissue repair with the introduction of the concept of precision medicine and drug delivery. In this review, we highlight different types of smart-responsive hydrogels and their mechanisms of response to different stimuli and discuss their potential for application in different types of tissue repair, such as chronic wound repair, damaged heart tissue repair, brain nerve tissue repair, and other fields. Finally, we present the prospects of smart-responsive hydrogels in tissue repair. In general, the current progress in the application of smart-responsive hydrogels in tissue repair lays the foundation for future applications in other diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent advances in smart‐responsive hydrogels for tissue repairing

Yang

Wang

2022

MedComm – Biomaterials and Applications

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“…Cancer is a group of diseases affecting different organs or systems. It is considered to be developed by multiple carcinogenesis mechanisms involving a range of physiological systems like signaling pathways and cell death in cancer cells. , Though they occur in a particular part, eventually they spread to other regions in the body, making it more complex to cure. The occurrence of cancer can be controlled to some extent by avoidance of smoking and high alcohol consumption and dietary restrictions.…”

Section: Introductionmentioning

confidence: 99%

Multifaceted Engineered Biomimetic Nanorobots Toward Cancer Management

Nehru

Misra

Bhaswant

2022

ACS Biomater. Sci. Eng.

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The noteworthy beneficiary to date in nanotechnology is cancer management. Nanorobots are developed as the result of advancements in the nanostructure, robotics, healthcare, and computer systems. These devices at the nanoscale level are beneficial in the prevention, diagnosis, and treatment of various health conditions notably cancer. Though these structures have distinct potentialities, the usage of inorganic substances in their construction can affect their performance and can cause health issues in the body. To overcome this, naturally inspired substances are incorporated in the fabrication process of nanorobots termed biomimetic nanorobots that can overcome the immunological responses and reduce the side effects with effective functionalization. These biomimetic nanorobots can widen the opportunities in cancer imaging and therapy. Herein, an up-to-date review of biomimetic nanorobots along with their applications in cancer management is provided. Furthermore, the safety issues and future directions of biomimetic nanorobots to achieve clinical translation are also stated.

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“…The physical cross‐linking process of a hydrogel, which leads to conformational changes and prevents dispersion in aqueous media, is generally reversible. Whereby chemical cross‐linking is an irreversible mechanism that causes obtaining stable hydrogels 29 . Chemical cross‐linking can take place as a result of the use of cross‐linking agents, chemical or radiation grafting reactions, condensation reactions, addition reactions, radical polymerization, enzymatic reactions, or through high‐energy radiation.…”

Section: Introductionmentioning

confidence: 99%

“…Chemical cross‐linking can take place as a result of the use of cross‐linking agents, chemical or radiation grafting reactions, condensation reactions, addition reactions, radical polymerization, enzymatic reactions, or through high‐energy radiation. These processes result in the formation of covalent bonds between the polymer chains, which affect the mechanical strength properties and degree of hydrogel swelling, and also they determine particles transportation in the hydrogel matrix 11,27–29 . The hydrogels cross‐linked chemically are characterized by improved mechanical properties; however, cross‐linking agents used during the gelation process can not only affect the integrity of the substance, but they are also often toxic compounds that can cause undesirable reactions with bioactive substances present in the hydrogel matrix 11,30 …”

Section: Introductionmentioning

confidence: 99%

A comprehensive review on hydrogel materials in urology: Problems, methods, and new opportunities

et al. 2022

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Hydrogel materials provide an extremely promising group of materials that can find an increasingly wide range of use in treating urinary system conditions due to their unique properties. The present review describes achievements to date in terms of the use and development prospects of hydrogel materials applications in the treatment and reconstruction of the urinary system organs, which among others include: hydrogel systems of intravesical drug delivery, ureteral stents design, treatment of vesicoureteral reflux, urinary bladder and urethral defects reconstruction, design of modern urinary catheters and also solutions applied in urinary incontinence therapy (Figure 4). In addition, hydrogel materials find increasingly growing applications in the construction of educational simulation models of organs and specific conditions of the urinary system, which enable the education of medical personnel. Numerous research efforts are underway to expand the existing treatment methods and reconstruction of the urinary system based on hydrogel materials. After conducting the further necessary research, many of the innovative solutions developed to date have high application potential.

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Smart nanotheranostic hydrogels for on-demand cancer management

Cited by 17 publications

References 105 publications

Recent advances in smart‐responsive hydrogels for tissue repairing

Recent advances in smart‐responsive hydrogels for tissue repairing

Multifaceted Engineered Biomimetic Nanorobots Toward Cancer Management

A comprehensive review on hydrogel materials in urology: Problems, methods, and new opportunities

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