Smart Nanobots: The Future in Nanomedicine and Biotherapeutics

Ahmad, Usama; Faiyazuddin, Md.

doi:10.4172/2155-983x.1000e140

Cited by 11 publications

(5 citation statements)

References 10 publications

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“…Scientists are to produce increasingly more complex nanomachines such as red blood cells 2.0 (synthetic particles that are like real red blood cells and can stay longer in the body), microbivores (nanobots capable of destroying pathogens inside the body) [58] and nanobots which suck up ocean pollution [59]. Although they are still in the research and development phase, their potential is innumerable.…”

Section: Resultsmentioning

confidence: 99%

A Review on Dna Nanobots – A New Technique for Cancer Treatment

Thiruchelvi

2018

Asian J Pharm Clin Res

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Cancer is one of the deadliest diseases of this century. Tedious and painful radiation therapy and chemotherapy are administered using many drugs including antitumor antibiotics, which cause a lot of side effects. As an alternate, DNA nanorobots serve as a potential cancer treatment technique which is very much safer than other therapies and acts specifically as well. DNA nanobots are said to set a new milestone in the development of medical studies. The primary objective of this bot is to target and eliminate cancer cells from the human body. These bots are made of a single strand of DNA folded into the desired shape. The bots will have two states -an "off" position, where the clamshells are closed tightly to bypass healthy cells without any damage and an "on" position, where the clamshell opens up to expose cancerous cells to the drug so that the drug can do its job to eliminate the cancer cell. This novel idea will be actively used within the public when it passes its first human trial. In this review, we focus on eliminating cancer cells. Since the bot can be programmed and is capable enough to carry a payload, it can also be used to cure any other diseases as a secondary target. Creation of nanobots has been under progress already and may come within the public after an estimated time of 5 years.

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Section: Resultsmentioning

confidence: 99%

A Review on Dna Nanobots – A New Technique for Cancer Treatment

Thiruchelvi

2018

Asian J Pharm Clin Res

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“…DNA nanorobots are intelligent molecular devices used as cargos for targeted and controlled drug delivery, sensing, and imaging agents. 79 DNA nanorobotsprecisely folded DNA nanostructures that can respond to biological or chemical stimulican be employed as tiny machines for action at the targeted site. For example, Li et al designed an aptamer (AS1411)-conjugated DNA nanorobot that encapsulated therapeutic thrombin in the core.…”

Section: Different Classes Of Dna Nanodevices Used For Cancer Diagnos...mentioning

confidence: 99%

Aptamer-Programmed DNA Nanodevices for Advanced, Targeted Cancer Theranostics

Walia

Chandrasekaran

Chakraborty³

et al. 2021

ACS Appl. Bio Mater.

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DNA has been demonstrated to be a versatile material for construction at the nanoscale. DNA nanodevices are highly programmable and allow functionalization with multiple entities such as imaging modalities (fluorophores), targeting entities (aptamers), drug conjugation (chemical linkers), and triggered release (photoresponsive molecules). These features enhance the use of DNA nanodevices in biological applications, catalyzing the rapid growth of this domain of research. In this review, we focus on recent progress in the development and use of aptamer-functionalized DNA nanodevices as theranostic agents, their characterization, applications as delivery platforms, and advantages. We provide a brief background on the development of aptamers and DNA nanodevices in biomedical applications, and we present specific applications of these entities in cancer diagnosis and therapeutics. We conclude with a perspective on the challenges and possible solutions for the clinical translation of aptamer-functionalized DNA nanodevices in the domain of cancer therapeutics.

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“…Then, the functionalized drug easily forms a monolayer assembly when the drug was allowed to equilibrate the AgNPs. These methods are exploited for drug delivery of controlled and relaxed antibiotic to avoid side effects of overdosage [20] (Fig. 12).…”

Section: Antibacterial Activity Of Peg-protected Agnpsmentioning

confidence: 99%

Microwave Synthesis of Silver Nanoparticles by Polyol Method and Testing Their Synergistic Antibacterial Activity in the Presence of Vancomycin

Malathy

Revathi

Letticia

2018

Asian J Pharm Clin Res

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Objective: The aim of this study is to prepare silver nanoparticles (AgNPs) and nanorods using polyol under microwave heating method. Methods: The synthesized nanoparticles were characterized using UV-visible, infrared spectral studies (Fourier-transform infrared [FTIR]), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Finally, the antibacterial activity of polyethylene glycol (PEG) protected AgNPs, against a series of Gram-positive and Gram-negative bacteria, was studied. Results: From UV-visible spectroscopy studies, the growth rate of AgNPs was confirmed by measuring the change in absorbance of plasmon peak shape at different time intervals. FTIR spectroscopy studies showed the changes in the metal and the capping agents. SEM and TEM images revealed that very stable colloidal solutions of AgNPs with almost spherical and rod shape along with high monodispersity can be obtained with PEG protected AgNPs. Finally, the antibacterial activity of PEG protected AgNPs was investigated, which showed a synergistic role for the AgNPs along with vancomycin. Conclusion: Uniform and stable polymer protected AgNPs were synthesized using ethylene glycol, triethylene glycol, and PEG as reducing agent in the presence of polyvinylpyrrolidone.

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Smart Nanobots: The Future in Nanomedicine and Biotherapeutics

Cited by 11 publications

References 10 publications

A Review on Dna Nanobots – A New Technique for Cancer Treatment

A Review on Dna Nanobots – A New Technique for Cancer Treatment

Aptamer-Programmed DNA Nanodevices for Advanced, Targeted Cancer Theranostics

Microwave Synthesis of Silver Nanoparticles by Polyol Method and Testing Their Synergistic Antibacterial Activity in the Presence of Vancomycin

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