Smart multifunctional nanosystem: Next-generation drug delivery platform for drug-resistant breast cancer

Paul, Paramita; Mandal, Sanchita; Dua, Tarun K.; Mandal, Debabrata; Deepa, R Manasa

doi:10.1016/b978-0-12-821712-2.00012-8

Cited by 1 publication

(1 citation statement)

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“…Polymeric nanoparticles have piqued the interest of many researchers in the realm of medical biology owing to their high efficiency, ease of synthesis, long circulation time, biocompatibility, low toxicity, ability to absorb/encapsulate, and carry other molecules, and possibility of active targeting via surface modification (113,114). Polymeric nanoparticles can deliver a wide range of drug(s) that offer high surface to volume ratio and have enormous opportunity to ameliorate DN by virtue of their versatile physicochemical properties.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Nanomedicines for the management of diabetic nephropathy: present progress and prospects

Paul,

Chacko,

Dua

et al. 2023

Front. Endocrinol.

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Diabetic nephropathy (DN) is a serious microvascular consequence of diabetes mellitus (DM), posing an encumbrance to public health worldwide. Control over the onset and progress of DN depend heavily on early detection and effective treatment. DN is a major contributor to end-stage renal disease, and a complete cure is yet to be achieved with currently available options. Though some therapeutic molecules have exhibited promise in treating DN complications, their poor solubility profile, low bioavailability, poor permeation, high therapeutic dose and associated toxicity, and low patient compliance apprehend their clinical usefulness. Recent research has indicated nano-systems as potential theranostic platforms displaying futuristic promise in the diagnosis and treatment of DN. Early and accurate diagnosis, site-specific delivery and retention by virtue of ligand conjugation, and improved pharmacokinetic profile are amongst the major advantages of nano-platforms, defining their superiority. Thus, the emergence of nanoparticles has offered fresh approaches to the possible diagnostic and therapeutic strategies regarding DN. The present review corroborates an updated overview of different types of nanocarriers regarding potential approaches for the diagnosis and therapy of DN.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%