Smart multifunctional nanoparticles in nanomedicine

Abstract

Recent advances in nanotechnology caused a growing interest using nanomaterials in medicine to solve a number of issues associated with therapeutic agents. The fabricated nanomaterials with unique physical and chemical properties have been investigated for both diagnostic and therapeutic applications. Therapeutic agents have been combined with the nanoparticles to minimize systemic toxicity, increase their solubility, prolong the circulation half-life, reduce their immunogenicity and improve their distribution. Multifunctional nanoparticles have shown great promise in targeted imaging and therapy. In this review, we summarized the physical parameters of nanoparticles for construction of "smart" multifunctional nanoparticles and their various surface engineering strategies. Outlook and questions for the further researches were discussed.

Fri0140 evaluation of Effectiveness and Usage Patterns of Tofacitinib in Treatment of Rheumatoid Arthritis in Australia: An Analysis From the Opal-Qumi Real World Dataset

“…. For the SF36 PCS at 12 weeks:JAK-i:+4,82 IC95% [3,88,5.77] and bDMARDs : +3,99 IC95% [2,81,5,18] .…”

“…More head-to-head studies are needed to draw definitive conclusions on potential efficacy differences between JAK-inhibitor and bDMARDs in RA. Background: The combination of methotrexate (MTX) with leflunomide (LEF), despite being effective in the therapy of rheumatoid arthritis (RA) [1], has not been widely accepted [2,3]. In spite of evidence that the MTX-LEF combination is generally safe [1,4,5], the relatively small number of patients and treatment courses have not permitted firm conclusions.…”

Nanoparticles: synthesis and applications

“…The purpose of the functionalization is manyfold, such as surface modification, the ability to increase the functionality, dispersibility, and stability, controlled release of the single nanoparticles, reduction in consumption of materials, etc. Applications of different multifunctional nanoparticles are summarized in review articles by Karele et al (2006), Seleci et al (2016), Jia et al (2013), and Bao et al (2013). The multifunctional nanoparticles are widely used in various applications such as pharmaceutical applications (Caruso, 2001), biomedical (Balakrishnan et al, 2009;Salgueirino-Maceira and Correa-Duarte, 2007), catalysis (Daniel and Astruc, 2004;Phadtare et al, 2003), electronics (Kortan et al, 1990;Qi et al, 1996), enhancing photoluminescence (Mews et al, 1994;Kamat and Shanghavi, 1997), creating photonic crystals (Scodeller et al, 2008), etc.…”

Cockle Shell-Derived Calcium Carbonate (Aragonite) Nanoparticles: A Dynamite to Nanomedicine

“…Hence, the shape and nature remains unaltered while the size increases after loading depending on the existing bond interactions between the nanoparticles and the type of drug loaded [11,17]. Drug molecules consolidation onto a nanoparticle occurs during nanocarrier synthesis followed by adsorption of the drug leading to drug incubation within the nanocarrier [142]. Thus CSCaCO 3 NP is capable of loading drug molecules in large quantity due to its large surface area, functional group endings and porosity through the process of adsorption [143].…”