Smart micelles self-assembled from four-arm star polymers as potential drug carriers for pH-triggered DOX release

Yu, Chao; Wang, Lei; Xu, Zhenzhu; Teng, Wenqi; Wu, Zhimin; Xiong, Di

doi:10.1007/s10965-020-02108-2

Cited by 11 publications

(8 citation statements)

References 43 publications

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“…The pH‐sensitivity of the polymers was confirmed by the increase of PTX delivery rate and cumulative release from 20% to 50% as the pH dropped from 7.4 to 5.0, due to the protonation of the PDEAEMA segment causing the micelles to swell (Figure 11). A similar behavior has been also observed by other authors for the release of DOX from micelles composed of pH‐responsive 4‐arm PCL‐ b ‐PDMAEMA star BCPs 144 . Unimolecular micelles prepared from dendrimers, star polymers and hyperbranched polymers possess high stability in comparison to the ones formed by linear amphiphilic BCPs, regardless of concentration, temperature, and pH, and have been explored for drug delivery purposes 145,146 .…”

Section: Degradable Star Bcps For Drug Deliverysupporting

confidence: 78%

“…A similar behavior has been also observed by other authors for the release of DOX from micelles composed of pH-responsive 4-arm PCL-b-PDMAEMA star BCPs. 144 Unimolecular micelles prepared from dendrimers, star polymers and hyperbranched polymers possess high stability in comparison to the ones formed by linear amphiphilic BCPs, regardless of concentration, temperature, and pH, and have been explored for drug delivery purposes. 145,146 By adjusting the hydrophilic/hydrophobic block composition, it is possible to use these systems as nanocontainers for the preparation of metallic nanoparticles with well-defined size.…”

Section: Stimuli-responsive Star Bcpsmentioning

confidence: 99%

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Amphiphilic well‐defined degradable star block copolymers by combination of ring‐opening polymerization and atom transfer radical polymerization: Synthesis and application as drug delivery carriers

Oliveira

Mendonça

Simões

et al. 2021

Journal of Polymer Science

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Atom transfer radical polymerization (ATRP) is one of the most popular advanced polymerization techniques in macromolecular science, allowing the synthesis of tailor-made polymers with controlled molecular weight, architecture, composition, and functionality. The combination of ATRP and ringopening polymerization (ROP) provides a straightforward route for the preparation of polymers exhibiting both targeted and well-defined features and biodegradability, which is very interesting for the development of new materials for biomedical applications. Among the different types of polymer architectures, amphiphilic star block copolymers (BCPs) represent a very attractive one, due to their high degree of functionality at the molecular surface, low hydrodynamic volume and higher encapsulation ability, compared to molecular systems based on linear polymers. This review article highlights the research focused on the synthesis of amphiphilic well-defined degradable star BCPs by combination of ROP and ATRP, with particular focus on the development of polymers for biomedical applications, such as anticancer drug delivery, diagnosis therapy, or photodynamic therapy, which is the most investigated field regarding these polymers.

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Section: Degradable Star Bcps For Drug Deliverysupporting

confidence: 78%

Section: Stimuli-responsive Star Bcpsmentioning

confidence: 99%

Amphiphilic well‐defined degradable star block copolymers by combination of ring‐opening polymerization and atom transfer radical polymerization: Synthesis and application as drug delivery carriers

Oliveira

Mendonça

Simões

et al. 2021

Journal of Polymer Science

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“…In the case of hydrophobic solvent, this effect is reversed, as micelles with hydrophilic cores and hydrophobic shells self-assemble with the increase of surfactant concentration and when the critical micelle concentration is reached. As a function of the composition of the amphiphilic molecule, the region in contact with the solvent can present different characteristics, which can be useful for the design of smart sustained release nanoparticles, such as pH gradient-dependent release [ 35 ]. For drug delivery purposes micelles are typically formulated with a hydrophobic core encapsulating hydrophobic drugs, with functionalities such as folic acid, glucose and monoclonal antibodies decorating the hydrophilic region [ 14 ].…”

Section: Smart Sustained Release Nanoparticlesmentioning

confidence: 99%

“…For drug delivery purposes micelles are typically formulated with a hydrophobic core encapsulating hydrophobic drugs, with functionalities such as folic acid, glucose and monoclonal antibodies decorating the hydrophilic region [ 14 ]. Yu et al [ 35 ] reported on the synthesis of pH-sensitive smart sustained-release micelles to release doxorubicin. A four-arm star polymer, poly(e-caprolactone)-b-poly(2-(diethylamino)ethylmethacrylate), was used to form micelles.…”

Section: Smart Sustained Release Nanoparticlesmentioning

confidence: 99%

Sustained Drug Release from Smart Nanoparticles in Cancer Therapy: A Comprehensive Review

et al. 2022

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Although nanomedicine has been highly investigated for cancer treatment over the past decades, only a few nanomedicines are currently approved and in the market; making this field poorly represented in clinical applications. Key research gaps that require optimization to successfully translate the use of nanomedicines have been identified, but not addressed; among these, the lack of control of the release pattern of therapeutics is the most important. To solve these issues with currently used nanomedicines (e.g., burst release, systemic release), different strategies for the design and manufacturing of nanomedicines allowing for better control over the therapeutic release, are currently being investigated. The inclusion of stimuli-responsive properties and prolonged drug release have been identified as effective approaches to include in nanomedicine, and are discussed in this paper. Recently, smart sustained release nanoparticles have been successfully designed to safely and efficiently deliver therapeutics with different kinetic profiles, making them promising for many drug delivery applications and in specific for cancer treatment. In this review, the state-of-the-art of smart sustained release nanoparticles is discussed, focusing on the design strategies and performances of polymeric nanotechnologies. A complete list of nanomedicines currently tested in clinical trials and approved nanomedicines for cancer treatment is presented, critically discussing advantages and limitations with respect to the newly developed nanotechnologies and manufacturing methods. By the presented discussion and the highlight of nanomedicine design criteria and current limitations, this review paper could be of high interest to identify key features for the design of release-controlled nanomedicine for cancer treatment.

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“…Therefore, in this research work, we design the temperature/reduction dual stimulus response triblock copolymer via ring-opening polymerization (ROP) [39,40] and atom transfer radical polymerization (ATRP) [41,42] technology, in which the hydrophobic segment is PLLA-SS-PLLA and the hydrophilic segment is P(MEO 2 MA-co-OEGMA). The study on the properties of the synthesized amphiphilic copolymer and the drug release behavior not only proves that the spherical micelles formed from self-assembly in water are a good carrier for hydrophobic anticancer drugs, but also the drug-loaded micelles have a precise targeting effect in tumor cells under the co-stimulation of temperature and reducing environment.…”

Section: Introductionmentioning

confidence: 99%

Novel Temperature/Reduction Dual-Stimulus Responsive Triblock Copolymer [P(MEO2MA-co- OEGMA)-b-PLLA-SS-PLLA-b-P(MEO2MA-co-OEGMA)] via a Combination of ROP and ATRP: Synthesis, Characterization and Application of Self-Assembled Micelles

et al. 2020

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Novel temperature/reduction dual stimulus-responsive triblock copolymers, poly [2-(2-methoxyethoxy) ethyl methacrylate-co-oligo (ethylene glycol) methacrylate]-b-(L-polylactic acid)-SS-b-(L-polylactic acid)-b-poly[2-(2-methoxyethoxy) ethyl methacrylate-co-oligo(ethylene glycol)methacrylate] [P(MEO2MA-co-OEGMA)-b-PLLA-SS-PLLA-b-P(MEO2MA-co-OEGMA)] (SPMO), were synthesized by ring opening polymerization (ROP) of L-lactide and 2,2’-dithio diethanol (SS-DOH), and random copolymerization of MEO2MA and OEGMA monomers via atom transfer radical polymerization (ATRP) technology. The chemical structures and compositions of the novel copolymers were demonstrated by proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared spectroscopy (FTIR). The molecular weights of the novel copolymers were measured by size exclusive chromatography (SEC) and proved to have a relatively narrow molecular weight distribution coefficient (ÐM ≤ 1.50). The water solubility and transmittance of the novel copolymers were tested via visual observation and UV–Vis spectroscopy, which proved the SPMO had a good hydrophilicity and suitable low critical solution temperature (LCST). The critical micelle concentration (CMC) of the novel polymeric micelles were determined using surface tension method and fluorescent probe technology. The particle size and morphology of the novel polymeric micelles were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The sol–gel transition behavior of the novel copolymers was studied via vial flip experiments. Finally, the hydrophobic anticancer drug doxorubicin (DOX) was used to study the in vitro release behavior of the novel drug-loaded micelles. The results show that the novel polymeric micelles are expected to become a favorable drug carrier. In addition, they exhibit reductive responsiveness to the small molecule reducing agent dithiothreitol (DTT) and temperature responsiveness with temperature changes.

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Smart micelles self-assembled from four-arm star polymers as potential drug carriers for pH-triggered DOX release

Cited by 11 publications

References 43 publications

Amphiphilic well‐defined degradable star block copolymers by combination of ring‐opening polymerization and atom transfer radical polymerization: Synthesis and application as drug delivery carriers

Amphiphilic well‐defined degradable star block copolymers by combination of ring‐opening polymerization and atom transfer radical polymerization: Synthesis and application as drug delivery carriers

Sustained Drug Release from Smart Nanoparticles in Cancer Therapy: A Comprehensive Review

Novel Temperature/Reduction Dual-Stimulus Responsive Triblock Copolymer [P(MEO2MA-co- OEGMA)-b-PLLA-SS-PLLA-b-P(MEO2MA-co-OEGMA)] via a Combination of ROP and ATRP: Synthesis, Characterization and Application of Self-Assembled Micelles

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