Smart metal organic frameworks: focus on cancer treatment

Abstract

Metal–organic frameworks (MOFs), as a prominent category of hybrid porous materials, have been broadly employed as controlled systems of drug delivery due to their inherent interesting properties.

Recent advances in porous MOFs and their hybrids for photothermal cancer therapy

“…36–38 Although these systems exhibit excellent photothermal conversion efficiency and good stability, the lack of biodegradability and biocompatibility still restrict their development. Recently, metal–organic frameworks (MOFs), 39–61 an emerging class of inorganic–organic hybrid porous materials, have been proven to be potential candidates for PTT. Compared with traditional porous materials, the outstanding advantages of MOFs in PTT are as follows: (1) designable inorganic nodes and organic linkers offer great potential for fabrication of functionalized MOFs using photothermal agents as organic ligands; (2) simple fabrication methods can introduce inorganic or polymer materials into MOFs; (3) large surface area and suitable pore size enable encapsulation of PTT agents; (4) some endogenous metals and superior biodegradation guarantee biocompatibility and therapeutic efficacy.…”

Photoresponsive Metal‐Organic Frameworks: Tailorable Platforms of Photoswitches for Advanced Functions

“…These include high porosity, low density, structural diversity and directionality, as well as large specific surface area. [2] Furthermore, the existence of various interactions, including metal-ligand coordination, hydrogen bonding and π-π stacking, have made MOFs appealing, promising and diverse materials that may find applications in numerous scenarios, such as the adsorption, [3] storage and separation of gases, [4] catalysis, [5] sensing, [6] drug delivery, [7] cancer treatment [8] and so on.…”

Ibuprofen Loaded into Metal–Organic Framework Shells Coated on Fe3O4 Nanoparticles for the Removal of Protein-Bound Uremic Toxins in Blood

“…It has good stability in water and uses metallic Fe instead of Zr as the metal node. In addition, as an essential nutrient element for the body, metal Fe has almost no biological toxicity . Moreover, MOF can also bind to PCS through electrostatic and hydrophobic interactions, making it a good candidate material for the removal of PBUTs. ,, …”

“…In addition, as an essential nutrient element for the body, metal Fe has almost no biological toxicity. 29 Moreover, MOF can also bind to PCS through electrostatic and hydrophobic interactions, making it a good candidate material for the removal of PBUTs. 19,28,30 On the basis of the above background, in this case, a novel kind of Fe 3 O 4 /MOF/IBU nanoremover was prepared for the removal of PCS, one kind of PBUTs.…”