Smart materials on the way to theranostic nanorobots: Molecular machines and nanomotors, advanced biosensors, and intelligent vehicles for drug delivery

Sokolov, I. L.; Cherkasov, V. R.; Tregubov, Andrey A.; Buiucli, Sveatoslav R.; Nikitin, Maxim P.

doi:10.1016/j.bbagen.2017.01.027

Cited by 68 publications

(51 citation statements)

References 224 publications

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“…Indeed, most of the existing biosensors employ irreversible binding to analyte, and the sensing nanoparticles or molecules cannot be reused and become insensitive to subsequent changes in concentration of detectible molecules (Ivanov and Zubov 2016;Lin et al 2016;Sokolov et al 2017). Therefore, it is impossible to use such sensors for real-time measurements or monitoring.…”

Section: Discussionmentioning

confidence: 99%

Smart multifunctional nanoagents for in situ monitoring of small molecules with a switchable affinity towards biomedical targets

et al. 2018

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The great diversity of nanomaterials provides ample opportunities for constructing effective agents for biomedical applications ranging from biosensing to drug delivery. Multifunctional nanoagents that combine several features in a single particle are of special interest due to capabilities that substantially exceed those of molecular drugs. An ideal theranostic agent should simultaneously be an advanced biosensor to identify a disease and report the diagnosis and a biomedical actuator to treat the disease. While many approaches were developed to load a nanoparticle with various drugs for actuation of the diseased cells (e.g., to kill them), the nanoparticle-based approaches for the localized biosensing with real-time reporting of the marker concentration severely lag behind. Here, we show a smart in situ nanoparticle-based biosensor/actuator system that dynamically and reversibly changes its structural and optical properties in response to a small molecule marker to allow real-time monitoring of the marker concentration and adjustment of the system ability to bind its biomedical target. Using the synergistic combination of signal readout based on the localized surface plasmon resonance and an original method of fabrication of smart ON/OFF-switchable nanoagents, we demonstrate reversible responsiveness of the system to a model small molecule marker (antibiotic chloramphenicol) in a wide concentration range. The proposed approach can be used for the development of advanced multifunctional nanoagents for theranostic applications.

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Section: Discussionmentioning

confidence: 99%

Smart multifunctional nanoagents for in situ monitoring of small molecules with a switchable affinity towards biomedical targets

et al. 2018

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“…The design, safety and motion freedom are greatly facilitated in externally driven nanorobots, usually referred as nanoswimmers (8). These systems can present intrinsic magnetism or embedded magnetic nanoparticles; specific geometry/material-driven torque formation when exposed to stimuli; and material-mediated hydrolyzing properties under UV light (for which the in vivo application is debatable) (6). Mixed propulsion systems have also been investigated (9).…”

Section: Nanotechnology Systemsmentioning

confidence: 99%

Nanotechnology and stem cells in vascular biology

et al. 2019

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Nanotechnology and stem cells are one of the most promising strategies for clinical medicine applications. The article provides an up-to-date view on advances in the field of regenerative and targeted vascular therapies describing a molecular design (propulsion mechanism, composition, target identification) and applications of nanorobots. Stem cell paragraph presents current clinical application of various cell types involved in vascular biology including mesenchymal stem cells, very small embryonic-like stem cells, induced pluripotent stem cells, mononuclear stem cells, amniotic fluid-derived stem cells and endothelial progenitor cells. A possible bridging between the two fields is also envisioned, where bio-inspired, safe, long-lasting nanorobots can fully target the cellular specific cues and even drive vascular process in a timely manner.

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“…A wide range of nano/microvehicles based on different propulsion mechanisms have been developed in recent years. 5 , 6 These vehicles can be classified into three different types based on their propulsion mechanism: (1) those with their own built-in propulsion powered by energy-rich molecules, (2) those with external energy sources such as magnetic or acoustic fields, and (3) systems “towed” to the site of interest by living objects with propulsion functions. In the case of autonomous systems, the engine must be equipped with some sort of navigation system to direct the nano/microvehicle to the target, while the direction of externally powered systems must be guided by an operator.…”

Section: Nano/microvehiclesmentioning

confidence: 99%

Nano/microvehicles for efficient delivery and (bio)sensing at the cellular level

Ávila²,

et al. 2017

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Smart materials on the way to theranostic nanorobots: Molecular machines and nanomotors, advanced biosensors, and intelligent vehicles for drug delivery

Cited by 68 publications

References 224 publications

Smart multifunctional nanoagents for in situ monitoring of small molecules with a switchable affinity towards biomedical targets

Smart multifunctional nanoagents for in situ monitoring of small molecules with a switchable affinity towards biomedical targets

Nanotechnology and stem cells in vascular biology

Nano/microvehicles for efficient delivery and (bio)sensing at the cellular level

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