Smart Janus membrane for on-demand separation of oil, bacteria, dye, and metal ions from complex wastewater

Hu, Jietao; Gui, Lishuang; Zhu, Mingning; Liu, Kuiliang; Chen, Ya; Wang, Xiaopan; Lin, Jing

doi:10.1016/j.ces.2022.117586

Cited by 25 publications

(7 citation statements)

References 58 publications

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“…When the PVA/CS/Ag superhydrophilic layer absorbs water in the blood or comes into contact with water in the blood through PVA and water molecules to form a hydration layer, the hydration layer can resist lipophilic substances and block bacterial adhesion because the bacterial cell walls are lipophilic. The bacterial antiadhesion effect of the hydration layer is also reported in our other works [51][52][53]. In addition, the synergistic antibacterial action of CS and Ag can reduce the total Fig.…”

Section: Antibacterial and Bacterial Antiadhesion Of The Janus Compos...supporting

confidence: 80%

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Hemostatic, antiextravasation, and prehealing drug droplet directional transportation of antibacterial Janus wound plaster based on the structural and wettability gradients

Lin

Hua

Yao

et al. 2022

Preprint

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Uncontrolled bleeding and bacterial infections are major causes of wounds that do not heal. However, developing a wound plaster that can stop bleeding, resist blood extravasation, and realize directional transportation of drugs to promote wound healing remains a significant challenge. This study developed a superhydrophilic/hydrophobic PVA/CS/Ag@TPU Janus membrane with structural and wettability gradients. Water is absorbed from blood via the superhydrophilic layer attached to the wound and charge interactions between introduced chitosan (CS) and platelets promote blood clotting. The capillary pressure resistance (∆p > 0) from the superhydrophilic layer to the hydrophobic layer can prevent blood from permeating, reducing blood loss. A favorable ∆p ( < 0 ) based on structural and wettability gradients can realize the directional transportation of drugs that promote wound healing from the hydrophobic to superhydrophilic layer. The incorporation of CS and Ag endows Janus wound plaster with intrinsic antibacterial activity (99.9%). The bacterial antiadhesion capability of wound plaster can be achieved due to the resisting effect of the hydrated layer that formed on the hydrophilic layer, its low adhesion, and antibacterial capability. Experiments on mice with full-thickness skin defects showed that the wound-healing rate using the Janus membrane after dosing with a drug increased from 87.65% (without the drug) to approximately 100%. Moreover, it could accelerate wound healing, regenerate epidermal and granulation tissue, promote collagen formation, and reduce the scar area. This gradient-design strategy opens an avenue for next-generation wound dressings.

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Section: Antibacterial and Bacterial Antiadhesion Of The Janus Compos...supporting

confidence: 80%

“…Bacterial antiadhesion capabilities of samples were evaluated using a slight modi cation of the methodology reported by Lin et al [46][47][48][49][50][51][52]. The PVA and Janus membranes were cut into 1 cm diameter discs.…”

Section: Bacterial Antiadhesion Test and Live/dead Bacteria Uorescenc...mentioning

confidence: 99%

Hemostatic, antiextravasation, and prehealing drug droplet directional transportation of antibacterial Janus wound plaster based on the structural and wettability gradients

Lin

Hua

Yao

et al. 2022

Preprint

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“…[191] Meanwhile, the combination of stimuli-responsive and Janus-featured separation materials have greater competitiveness for the separation of complex oily wastewater, which gives us a signal that the ondemand oil/water separation materials with intelligent-responsive property is more and more important in separation. [192] Figure 25. Schematic of the application of the on-demand superwetting materials from the a) oil/water mixture separation, and b) immiscible organic liquid separation.…”

Section: Discussionmentioning

confidence: 99%

Special Superwetting Materials from Bioinspired to Intelligent Surface for On‐Demand Oil/Water Separation: A Comprehensive Review

Yang

Guo

Liu

2022

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Since superwetting surfaces have emerged, on-demand oil/water separation materials serve as a new direction for meeting practical needs. This new separation mode uses a single porous material to allow oil-removing and water-removing to be achieved alternately. In this review, the fundamentals of wettability are systematically summarized in oil/water separation. Most importantly, the two states, bioinspired surface and intelligent surface, are summarized for on-demand oil/water separation. Specifically, bioinspired surfaces include micro/nanostructures, bioinspired chemistry, Janus-featured surfaces, and dual-superlyophobic surfaces that these superwetting materials can possess asymmetric wettability in one structure system or opposite underliquid wettability by prewetting. Furthermore, an intelligent surface can be adopted by various triggers such as pH, thermal and photo stimuli, etc., to control wettability for switchable oil/water separation reversibly, expressing a thought beyond nature to realize innovative oil/water separation by external stimuli. Remarkably, this review also discusses the advantages of all the materials mentioned above, expanding the separation scope from the on-demand oil/water mixtures to the multiphase immiscible liquid-liquid mixtures. Finally, the prospects of on-demand oil/water separation materials are also concluded.

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“…The bacterial antiadhesion properties of the samples were evaluated using a slightly modi ed version of a methodology reported by Lin et al [46][47][48][49][50][51][52]. Brie y, the PVA and Janus membranes were sectioned into 1-cm diameter disks and separately placed in test tubes where the hydrophilic layer of the Janus membrane was placed toward the mouth of the tube.…”

Section: Bacterial Antiadhesion Test and Live/dead Bacteria Uorescenc...mentioning

confidence: 99%

Directional transport of drug droplets based on structural and wettability gradients

Lin,

Yao,

Hua

et al. 2023

Preprint

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The failure of wound healing is majorly attributed to uncontrolled bleeding and bacterial infections. However, developing a wound plaster that can stop bleeding, resist blood extravasation, and realize directional transportation of drugs to promote wound healing remains a significant challenge. Herein, we developed a superhydrophilic/hydrophobic PVA/CS/Ag@TPU Janus membrane with structural and wettability gradients. In this newly developed membrane, water is absorbed from blood via the superhydrophilic layer, which is attached to the wound, and the charge interactions between platelets and the introduced chitosan (CS) promote blood clotting. The capillary pressure resistance (∆p > 0) of the superhydrophilic layer toward the hydrophobic layer prevents blood permeation, thereby reducing blood loss. The favorable ∆p (< 0) of the membrane based on its structural and wettability gradients can realize the directional transportation of drugs that promote wound healing from the hydrophobic to the superhydrophilic layer. The incorporation of CS and silver endows the Janus membrane with intrinsic antibacterial properties (99.9%). The formation of the hydrated layer on the hydrophilic layer imparts a resisting effect, further endowing the membrane with antiadhesion and antibacterial properties. Experiments involving mice with full-thickness skin wounds revealed that the wound-healing rate increased from 87.65% to ~ 100% when the Janus membrane was loaded with the prehealing drug. Moreover, the dressing accelerated wound healing, regenerated epidermal and granulation tissues, promoted collagen formation, and reduced scar size. Thus, this gradient design strategy opens an avenue for the development of next-generation wound dressings.

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Smart Janus membrane for on-demand separation of oil, bacteria, dye, and metal ions from complex wastewater

Cited by 25 publications

References 58 publications

Hemostatic, antiextravasation, and prehealing drug droplet directional transportation of antibacterial Janus wound plaster based on the structural and wettability gradients

Hemostatic, antiextravasation, and prehealing drug droplet directional transportation of antibacterial Janus wound plaster based on the structural and wettability gradients

Special Superwetting Materials from Bioinspired to Intelligent Surface for On‐Demand Oil/Water Separation: A Comprehensive Review

Directional transport of drug droplets based on structural and wettability gradients

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