Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy

Li, Wenjun; Zheng, Cuifang; Zhang, Pan; Chen, Chi; Hu, Dehong; Gao, Guanhui; Kang, Shendong; Cui, Haodong; Gong, Ping; Cai, Lintao

doi:10.1016/j.biomaterials.2016.05.019

Cited by 108 publications

(68 citation statements)

References 34 publications

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“…The sizes and spherical shapes of nanoparticles were also confirmed by the transmission electron microscopy (TEM) measurement (Figure B). The size estimated from TEM was smaller than that from DLS in an aqueous phase, which might be ascribed to the different determination principles between DLS (hydrated radius) and TEM . In addition, the PFH@HSC and PFH@HEC nanoparticles presented a slightly increased diameter (about 20 nm) and negligible change in morphology compared with the corresponding unloaded HSC and HEC nanoparticles, respectively.…”

Section: Resultsmentioning

confidence: 79%

Perfluorocarbon‐Loaded and Redox‐Activatable Photosensitizing Agent with Oxygen Supply for Enhancement of Fluorescence/Photoacoustic Imaging Guided Tumor Photodynamic Therapy

Zhong

Wang

et al. 2019

Adv Funct Materials

131

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The wide clinical application of photodynamic therapy (PDT) is hampered by poor water solubility, low tumor selectivity, and nonspecific activation of photosensitizers, as well as tumor hypoxia which is common for most solid tumors. To overcome these limitations, tumor-targeting, redox-activatable, and oxygen self-enriched theranostic nanoparticles are developed by synthesizing chlorin e6 (Ce6) conjugated hyaluronic acid (HA) with reducible disulfide bonds (HSC) and encapsulating perfluorohexane (PFH) within the nanoparticles (PFH@HSC). The fluorescence and phototoxicity of PFH@HSC nanoparticles are greatly inhibited by a self-quenching effect in an aqueous environment. However, after accumulating in tumors through passive and active tumor-targeting, PFH@HSC appear to be activated from "OFF" to "ON" in photoactivity by the redox-responsive destruction of the vehicle's structure. In addition, PFH@HSC can load oxygen within lungs during blood circulation, and the oxygen dissolved in PFH is slowly released and diffuses over the entire tumor, finally resulting in remarkable tumor hypoxia relief and enhancement of PDT efficacy by generating more singlet oxygen. Taking advantage of the excellent imaging performance of Ce6, the tumor accumulation of PFH@HSC can be monitored by fluorescent and photoacoustic imaging after intravenous administration into tumor-bearing mice. This PFH@HSC nanoparticle might have good potential for dual imaging-guided PDT in hypoxic solid tumor treatment.

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Section: Resultsmentioning

confidence: 79%

Perfluorocarbon‐Loaded and Redox‐Activatable Photosensitizing Agent with Oxygen Supply for Enhancement of Fluorescence/Photoacoustic Imaging Guided Tumor Photodynamic Therapy

Zhong

Wang

et al. 2019

Adv Funct Materials

131

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“…Reactive oxygen species can also be detected with semiconducting polymer nanoparticles [145]. Other examples are sensors of hyaluronidase [262] or copper (II) [263]. …”

Section: Dynamic Contrast Enhancement Approachesmentioning

confidence: 99%

Advanced optoacoustic methods for multiscale imaging of in vivo dynamics

et al. 2017

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Visualization of dynamic functional and molecular events in an unperturbed in vivo environment is essential for understanding the complex biology of living organisms and of disease state and progression. To this end, optoacoustic (photoacoustic) sensing and imaging have demonstrated the exclusive capacity to maintain excellent optical contrast and high resolution in deep-tissue observations, far beyond the penetration limits of modern microscopy. Yet, the time domain is paramount for the observation and study of complex biological interactions that may be invisible in single snapshots of living systems. This review focuses on the recent advances in optoacoustic imaging assisted by smart molecular labeling and dynamic contrast enhancement approaches that enable new types of multiscale dynamic observations not attainable with other bio-imaging modalities. A wealth of investigated new research topics and clinical applications is further discussed, including imaging of large-scale brain activity patterns, volumetric visualization of moving organs and contrast agent kinetics, molecular imaging using targeted and genetically expressed labels, as well as three-dimensional handheld diagnostics of human subjects.

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“…Nowadays, a number of theranostic drug delivery systems have been prepared and investigated in vitro and in vivo. [43][44][45] In the previous studies, it was found that Mn 2+ and gold nanomaterials can be used for MRI and X-ray CT imaging for the early diagnosis of cancer, respectively. 41,46 Gold nanoshells and Fe 3 O 4 NPs have been used to prepare a core-shell structured delivery system that had the dual-mode imaging effect.…”

Section: Effects Of Mri and X-ray Imaging In Vivomentioning

confidence: 99%

Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications

Wang¹,

Liu²,

Hao³

et al. 2017

IJN

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Recently, photothermal therapy has become a promising strategy in tumor treatment. However, the therapeutic effect was seriously hampered by the low tissue penetration of laser. Therefore, in this study, radiofrequency (RF) with better tissue penetration was used for tumor hyperthermia. First, one type of gold nanorods (AuNRs) suitable for RF hyperthermia was selected. Then, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with AuNRs and docetaxel (DTX) (PLGA/AuNR/DTX) NPs were constructed. Finally, manganese dioxide (MnO 2 ) ultrathin nanofilms were coated on the surfaces of PLGA/AuNR/DTX NPs by the reduction of KMnO 4 to construct the PLGA/AuNR/DTX@MnO 2 drug delivery system. This drug delivery system can not only be used for the combined therapy of chemotherapy and RF hyperthermia but can also produce Mn 2+ to enable magnetic resonance imaging. Furthermore, the RF hyperthermia and the degradation of MnO 2 can significantly promote the controlled drug release in a tumor region. The in vitro and in vivo results suggested that the PLGA/AuNR/DTX@MnO 2 multifunctional drug delivery system is a promising nanoplatform for effective cancer theranostic applications.

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Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy

Cited by 108 publications

References 34 publications

Perfluorocarbon‐Loaded and Redox‐Activatable Photosensitizing Agent with Oxygen Supply for Enhancement of Fluorescence/Photoacoustic Imaging Guided Tumor Photodynamic Therapy

Perfluorocarbon‐Loaded and Redox‐Activatable Photosensitizing Agent with Oxygen Supply for Enhancement of Fluorescence/Photoacoustic Imaging Guided Tumor Photodynamic Therapy

Advanced optoacoustic methods for multiscale imaging of in vivo dynamics

Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications

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Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy

Cited by 108 publications

References 34 publications

Perfluorocarbon‐Loaded and Redox‐Activatable Photosensitizing Agent with Oxygen Supply for Enhancement of Fluorescence/Photoacoustic Imaging Guided Tumor Photodynamic Therapy

Perfluorocarbon‐Loaded and Redox‐Activatable Photosensitizing Agent with Oxygen Supply for Enhancement of Fluorescence/Photoacoustic Imaging Guided Tumor Photodynamic Therapy

Advanced optoacoustic methods for multiscale imaging of in vivo dynamics

Gold nanorod&ndash;based poly(lactic-co-glycolic acid) with manganese dioxide core&ndash;shell structured multifunctional nanoplatform for cancer theranostic applications

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Product

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Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications