Smart drug delivery: Capping strategies for mesoporous silica nanoparticles

Nik, Amirala Bakhshian; Zare, Hossein; Razavi, Seyedsahameddin; Mohammadi, Hesameddin; Ahmadi, Pooya Torab; Yazdani, Narges; Bayandori, Mehrdad; Rabiee, Navid; Mobarakeh, Jalal Izadi

doi:10.1016/j.micromeso.2020.110115

Cited by 96 publications

(60 citation statements)

References 199 publications

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“…Based on the confocal microscopy analysis, MSN-C-R101-70-PEG were internalized in the cells and specifically accumulated into the lysosomes as shown by the subcellular localization experiments ( Figure 6 ), where the lysotracker (green) and the nanoparticles (red) were co-localized (yellow). The fact that these NPs are localized into lysosomes indicates that they are possibly taken up by endocytosis, as widely reported for silica NPs at similar size range [ 82 , 83 ]. Note that the nanoparticles offer a sharper quality in the bioimaging of lysosomes with respect to commercial lysotrackers.…”

Section: Resultssupporting

confidence: 52%

Functionalized Fluorescent Silica Nanoparticles for Bioimaging of Cancer Cells

Prieto-Montero

Katsumiti

Cajaraville

et al. 2020

Sensors

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Functionalized fluorescent silica nanoparticles were designed and synthesized to selectively target cancer cells for bioimaging analysis. The synthesis method and characterization of functionalized fluorescent silica nanoparticles (50–60 nm), as well as internalization and subcellular localization in HeLa cells is reported here. The dye, rhodamine 101 (R101) was physically embedded during the sol–gel synthesis. The dye loading was optimized by varying the synthesis conditions (temperature and dye concentration added to the gel) and by the use of different organotriethoxysilanes as a second silica precursor. Additionally, R101, was also covalently bound to the functionalized external surface of the silica nanoparticles. The quantum yields of the dye-doped silica nanoparticles range from 0.25 to 0.50 and demonstrated an enhanced brightness of 230–260 fold respect to the free dye in solution. The shell of the nanoparticles was further decorated with PEG of 2000 Da and folic acid (FA) to ensure good stability in water and to enhance selectivity to cancer cells, respectively. In vitro assays with HeLa cells showed that fluorescent nanoparticles were internalized by cells accumulating exclusively into lysosomes. Quantitative analysis showed a significantly higher accumulation of FA functionalized fluorescent silica nanoparticles compared to nanoparticles without FA, proving that the former may represent good candidates for targeting cancer cells.

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Section: Resultssupporting

confidence: 52%

Functionalized Fluorescent Silica Nanoparticles for Bioimaging of Cancer Cells

Prieto-Montero

Katsumiti

Cajaraville

et al. 2020

Sensors

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“…It is known that due to their small size, nanoparticles have a relatively larger surface area than the bulk phases [26]. This feature predestines the use of nanoparticles in many scientific fields, including biological technologies [27]. High surface area leads to effective adsorption of biomolecules, which is very important for biosensors and drug delivery, The phase purity and composition of ZnO NPs obtained by a sol-gel method was examined by the XRD technique.…”

Section: Textural Propertiesmentioning

confidence: 99%

Fabrication of Gelatin-ZnO Nanofibers for Antibacterial Applications

et al. 2020

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In this study, GNF@ZnO composites (gelatin nanofibers (GNF) with zinc oxide (ZnO) nanoparticles (NPs)) as a novel antibacterial agent were obtained using a wet chemistry approach. The physicochemical characterization of ZnO nanoparticles (NPs) and GNF@ZnO composites, as well as the evaluation of their antibacterial activity toward Gram-positive (Staphyloccocus aureus and Bacillus pumilus) and Gram-negative (Escherichia coli and Pseudomonas fluorescens) bacteria were performed. ZnO NPs were synthesized using a facile sol-gel approach. Gelatin nanofibers (GNF) were obtained by an electrospinning technique. GNF@ZnO composites were obtained by adding previously produced GNF into a Zn2+ methanol solution during ZnO NPs synthesis. Crystal structure, phase, and elemental compositions, morphology, as well as photoluminescent properties of pristine ZnO NPs, pristine GNF, and GNF@ZnO composites were characterized using powder X-ray diffraction (XRD), FTIR analysis, transmission and scanning electron microscopies (TEM/SEM), and photoluminescence spectroscopy. SEM, EDX, as well as FTIR analyses, confirmed the adsorption of ZnO NPs on the GNF surface. The pristine ZnO NPs were highly crystalline and monodispersed with a size of approximately 7 nm and had a high surface area (83 m2/g). The thickness of the pristine gelatin nanofiber was around 1 µm. The antibacterial properties of GNF@ZnO composites were investigated by a disk diffusion assay on agar plates. Results show that both pristine ZnO NPs and their GNF-based composites have the strongest antibacterial properties against Pseudomonas fluorescence and Staphylococcus aureus, with the zone of inhibition above 10 mm. Right behind them is Escherichia coli with slightly less inhibition of bacterial growth. These properties of GNF@ZnO composites suggest their suitability for a range of antimicrobial uses, such as in the food industry or in biomedical applications.

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“…Así, los medicamentos con carga positiva solubles en agua prefieren ser adsorbidos en los poros y superficies con carga negativa de las MSN para formar un complejo estable de MSN/medicamento [41]. Las MSN se pueden modificar covalentemente con grupos funcionales orgánicos e inorgánicos [7] incluidos los hidruros [5] que mejoran la entrega selectiva [3], biodistribución [31] y la adsorción electrostática de medicamentos con diferentes cargas en MSN [41] al impedir las interacciones indeseables entre las nanopartículas y el medio ambiente [42]. Estos grupos funcionales incluyen pequeños fosfatos orgánicos como el fosfoenolpiruvato, tioles, polímeros que contienen amino como la polietilenimina (PEI), dendrímeros, polietilenglicol (PEG), fosfolípidos o sulfhidrilo [42,43].…”

Section: Funcionalizaciones Y Recubrimientos De Las Nanopartículas Deunclassified

“…Las MSN se pueden modificar covalentemente con grupos funcionales orgánicos e inorgánicos [7] incluidos los hidruros [5] que mejoran la entrega selectiva [3], biodistribución [31] y la adsorción electrostática de medicamentos con diferentes cargas en MSN [41] al impedir las interacciones indeseables entre las nanopartículas y el medio ambiente [42]. Estos grupos funcionales incluyen pequeños fosfatos orgánicos como el fosfoenolpiruvato, tioles, polímeros que contienen amino como la polietilenimina (PEI), dendrímeros, polietilenglicol (PEG), fosfolípidos o sulfhidrilo [42,43]. Además, se puede modificar la superficie de las MSN a través de la hidrólisis de silanos usando estrategias como la condensación conjunta [7], la hidrólisis-condensación, las reacciones post-sintéticas y el post-injerto.…”

Section: Funcionalizaciones Y Recubrimientos De Las Nanopartículas Deunclassified

Obtención, funcionalización y aplicaciones biomédicas de las Nanopartículas de Sílice Mesoporosa: una revisión

Hincapie

Hernández

González

et al. 2020

DYNA

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Recientemente, las nanopartículas inorgánicas han sido ampliamente investigadas como agentes terapéuticos en los campos biomédicos debido a sus propiedades físicas, químicas y biológicas excepcionales, su fácil funcionalización superficial, su capacidad de carga y su excelente biocompatibilidad. El creciente aumento en investigaciones centradas en nanopartículas inorgánicas en especial las de sílice ha permitido entender su comportamiento en aplicaciones biomédicas, debido a que es un biomaterial con alta resistencia mecánica, bioactividad y reabsorbilidad mejoradas. En este artículo, se realiza la revisión de estudios recientes basados en Nanopartículas de Sílice Mesoporosa (MSN) cuyo enfoque principal se centra en diferentes métodos de síntesis, funcionalización y recubrimiento de superficie y algunas aplicaciones biomédicas como liberación controlada de fármacos e imágenes diagnósticas. Finalmente, se presentan los impactos de las modificaciones químicas de la superficie de las nanopartículas en cuanto a su biocompatibilidad y las diversas aplicaciones biomédicas debido a sus destacables características.

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Smart drug delivery: Capping strategies for mesoporous silica nanoparticles

Cited by 96 publications

References 199 publications

Functionalized Fluorescent Silica Nanoparticles for Bioimaging of Cancer Cells

Functionalized Fluorescent Silica Nanoparticles for Bioimaging of Cancer Cells

Fabrication of Gelatin-ZnO Nanofibers for Antibacterial Applications

Obtención, funcionalización y aplicaciones biomédicas de las Nanopartículas de Sílice Mesoporosa: una revisión

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