Smart coumarin-tagged imprinted polymers for the rapid detection of tamoxifen

Ray, Judith Victoria; Mirata, Fosca; Pérollier, Céline; Arotçaréna, Michel; Bayoudh, Sami; Resmini, Marina

doi:10.1007/s00216-015-9296-8

Cited by 10 publications

(1 citation statement)

References 12 publications

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“…The applications of these systems have been developed in areas such as drug and gene delivery, 11,12 tissue engineering, 13 detection and sensing. 14 More recently, research has focused on materials with dual functionality, where two stimuli are combined. 15 In particular, materials showing dual temperature and pH response characteristics have been developed for drug delivery applications, 16 demonstrating efficient tailored release.…”

Section: Introductionmentioning

confidence: 99%

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

Salinas

Resmini

2018

Polym. Chem.

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The synthesis and characterisation of a novel dual stimuli-responsive nanogel, based on thermoresponsive N-n-propylacrylamide and an L-proline based monomer acting as a pH-switcher, is reported here. The effect of the crosslinker/co-monomer ratios was studied to demonstrate the relationship between the chemical structure, degree of hydrophobicity and physico-chemical characteristics of the nanogels. Tailoring of the thermoresponsive properties was achieved by altering crosslinker N,N'-methylenebis (acrylamide) content between 10 and 50 mol%, in combination with three thermoresponsive monomers N-n-isopropylacrylamide, N-n-propylacrylamide and N-acryloylpyrrolidine. A library of 25 different combinations of monomers and crosslinkers was obtained and characterised by dynamic light scattering and UV-Vis spectroscopy. The nanogel based on N-n-propylacrylamide and 10 mol% crosslinker was then co-polymerised with an L-proline based monomer to introduce a pH-switch. This nanogel was obtained with <10 nm particle size and a VPTT ca. 43°C, and was used to demonstrate a drug delivery capability using Nile Blue A as a model drug. Detailed studies demonstrated maximum drug release at lower pH and 43°C, thus confirming the dual stimuli switch.

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Section: Introductionmentioning

confidence: 99%

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

Salinas

Resmini

2018

Polym. Chem.

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Molecularly imprinted polymers fabricated via Pickering emulsions stabilized solely by food-grade casein colloidal nanoparticles for selective protein recognition

Sun

Zhong

2018

Anal Bioanal Chem

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Novel molecularly imprinted polymers (MIPs) based on denatured casein nanoparticle (DCP)-stabilized Pickering emulsions were developed for the first time. Casein, a phosphoprotein, is the main protein in milk. In this work, DCPs were solely used as Pickering-type interfacial emulsifiers for fabrication of MIPs for the selective recognition of proteins for the first time. DCPs were prepared by acidification and heat denaturation (at 80 °C) of casein. Their dispersions have satisfactory colloidal stability over a wide pH range. The DCPs acted as natural, food-grade, and edible interfacial emulsifiers, and adsorbed at the oil-water interface to form Pickering emulsions. After the polymerization of monomers, the template protein was removed by elution. During the elution, the interfacial DCPs were also removed, allowing more imprinted cavities to become exposed. The interfacial imprinting technology causes nearly all the imprinted sites to locate on the surface of the polymeric material. Therefore, the MIPs obtained exhibit fast rebinding and excellent specific recognition ability toward the analytes. Overall, this work provides a promising method for designing and fabricating natural-protein-based structured emulsions to prepare MIPs and thus offers new insight into protein separation and purification. Graphical Abstract Pickering emulsions stabilized by denatured casein particles.

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Molecularly imprinted polymers for the detection of illegal drugs and additives: a review

Xiao

2018

Microchim Acta

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This review (with 154 refs.) describes the current status of using molecularly imprinted polymers in the extraction and quantitation of illicit drugs and additives. The review starts with an introduction into some synthesis methods (lump MIPs, spherical MIPs, surface imprinting) of MIPs using illicit drugs and additives as templates. The next section covers applications, with subsections on the detection of illegal additives in food, of doping in sports, and of illicit addictive drugs. A particular focus is directed towards current limitations and challenges, on the optimization of methods for preparation of MIPs, their applicability to aqueous samples, the leakage of template molecules, and the identification of the best balance between adsorption capacity and selectivity factor. At last, the need for convincing characterization methods, the lack of uniform parameters for defining selectivity, and the merits and demerits of MIPs prepared using nanomaterials are addressed. Strategies are suggested to solve existing problems, and future developments are discussed with respect to a more widespread use in relevant fields. Graphical abstract This review gives a comprehensive overview of the advances made in molecularly imprinting of polymers for use in the extraction and quantitation of illicit drugs and additives. Methods for syntheses, highlighted applications, limitations and current challenges are specifically addressed.

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Smart coumarin-tagged imprinted polymers for the rapid detection of tamoxifen

Cited by 10 publications

References 12 publications

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

Molecularly imprinted polymers fabricated via Pickering emulsions stabilized solely by food-grade casein colloidal nanoparticles for selective protein recognition

Molecularly imprinted polymers for the detection of illegal drugs and additives: a review

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