Smart control of guest inclusion by α-cyclodextrin using its hydration history

Gatiatulin, Askar K.; Osel’skaya, Viktoria Yu.; Зиганшин, Марат А.; Gorbatchuk, Valery V.

doi:10.1039/c9ra08710a

Cited by 8 publications

(3 citation statements)

References 53 publications

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“…When comparing the composition and packing of inclusion compounds (solvates) determined by different methods, one should take into account that in the present work the inclusion compounds that are stable in air at RT were studied. The partial desolvation process often produces material with the same packing as for stoichiometric solvate but with a lower guest content according to refs , , , and .…”

Section: Resultsmentioning

confidence: 99%

New Polymorph of Indomethacin: Screening by Solid-State Guest Exchange and Characterization Using Fast Scanning Calorimetry

Gataullina,

Buzyurov,

Gerasimov

et al. 2023

Crystal Growth & Design

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Section: Resultsmentioning

confidence: 99%

New Polymorph of Indomethacin: Screening by Solid-State Guest Exchange and Characterization Using Fast Scanning Calorimetry

Gataullina,

Buzyurov,

Gerasimov

et al. 2023

Crystal Growth & Design

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“…Two model-free methods of Friedman [ 25 ] and Ozawa–Flynn–Wall [ 26 , 27 ] were used for approximation of the experimental data according to the recommendation of International Confederation for Thermal Analysis and Calorimetry [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Determination of Melting Parameters of Cyclodextrins Using Fast Scanning Calorimetry

Gatiatulin

Grishin

Buzyurov

et al. 2022

IJMS

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The first evidence of native cyclodextrins fusion was registered using fast scanning calorimetry (FSC) with heating rates up to 40,000 K s−1. The endothermal effects, detected at low heating rates, correspond to the decomposition processes. Upon the increase of the heating rate the onset of these effects shifts to higher temperatures, reaching a limiting value at high heating rates. The limiting temperatures were identified as the melting points of α-, β- and γ-cyclodextrins, as the decomposition processes are suppressed at high heating rates. For γ-cyclodextrin the fusion enthalpy was measured. The activation energies of thermal decomposition of cyclodextrins were determined by dependence of the observed thermal effects on heating rates from 4 K min−1 in conventional differential scanning calorimetry to 40,000 K s−1 in FSC. The lower thermal stability and activation energy of decomposition of β-cyclodextrin than for the other two cyclodextrins were found, which may be explained by preliminary phase transition and chemical reaction without mass loss. The obtained values of fusion parameters of cyclodextrins are needed in theoretical models widely used for prediction of solubility and solution rates and in preparation of cyclodextrin inclusion compounds involving heating.

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“…The guest inclusion by the host with a partial exchange of the already included water is a standard experimental procedure for solid hydrophilic hosts, such as native cyclodextrins (Ho et al, 2011(Ho et al, , 2016Gatiatulin et al, 2019) that do not include large hydrophobic guests in binary host-guest systems in the absence of water (Gorbatchuk et al, 2013;Gatiatulin et al, 2018). To activate this inclusion without water, the guest exchange in anhydrous inclusion compounds of cyclodextrins may be used (Gorbatchuk et al, 2013;Gatiatulin et al, 2014), which selectivity and efficiency depends much on molecular structure of the leaving guest.…”

Section: Selectivity Of Guest Exchange In Inclusion Compoundmentioning

confidence: 99%

Smart Molecular Recognition: From Key-to-Lock Principle to Memory-Based Selectivity

2020

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The formation and decomposition of inclusion compounds with a solid-solid phase transition may be very selective to the guest molecular structure. This selectivity may function in essentially different ways than defined by the classical concept of molecular recognition, which implies the preferential binding of complementary molecules. Solid inclusion compounds may take part as an initial or/and final state in several processes of different types summarized in this review, which selectivity is boosted by cooperativity of participating molecular crystals. Some of these processes resemble switching electronic devices and can be called smart giving practically absolute molecular recognition.

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Smart control of guest inclusion by α-cyclodextrin using its hydration history

Abstract: The hydration level and hydration history of alpha-cyclodextrin significantly affects its structure and inclusion capacity for organic guests.

Cited by 8 publications

References 53 publications

New Polymorph of Indomethacin: Screening by Solid-State Guest Exchange and Characterization Using Fast Scanning Calorimetry

New Polymorph of Indomethacin: Screening by Solid-State Guest Exchange and Characterization Using Fast Scanning Calorimetry

Determination of Melting Parameters of Cyclodextrins Using Fast Scanning Calorimetry

Smart Molecular Recognition: From Key-to-Lock Principle to Memory-Based Selectivity

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