Smart cellulose-derived magnetic hydrogel with rapid swelling and deswelling properties for remotely controlled drug release

Lin, Fengcai; Zheng, Junjian; Guo, Weihong; Zhu, Zhiting; Wang, Zi; Dong, Biying; Lin, Chensheng; Huang, Biao; Lu, Beili

doi:10.1007/s10570-019-02572-0

Cited by 58 publications

(42 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Magnetic hydrogels based on natural polymers are preferable over the other gels because of their enhanced sustainability, biocompatibility, biodegradation, and nontoxicity [ 12 ]. Biocompatible magnetic hydrogels are very promising as catheters for remotely controlled manipulation systems [ 17 ], microgrippers for excising cells and intravascular surgery [ 18 ], vehicles for magnetically guided drug delivery [ 19 , 20 , 21 , 22 ], and so forth. Biopolymer magnetic gels not only provide the possibility of biomedical applications, but also (which is even more important) significantly reduce the environmental pollution.…”

Section: Introductionmentioning

confidence: 99%

“…Biopolymer magnetic gels not only provide the possibility of biomedical applications, but also (which is even more important) significantly reduce the environmental pollution. Usually, such hydrogels are produced from various polysaccharides including sodium alginate [ 23 , 24 ], cellulose [ 22 , 25 ] and its derivatives [ 26 ], κ-carrageenan [ 27 ], chitosan [ 28 , 29 ] and its derivatives [ 30 ], agarose [ 31 ], starch [ 21 ], and some others.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Remotely Self-Healable, Shapeable and pH-Sensitive Dual Cross-Linked Polysaccharide Hydrogels with Fast Response to Magnetic Field

et al. 2021

View full text Add to dashboard Cite

The development of actuators with remote control is important for the construction of devices for soft robotics. The present paper describes a responsive hydrogel of nontoxic, biocompatible, and biodegradable polymer carboxymethyl hydroxypropyl guar with dynamic covalent cross-links and embedded cobalt ferrite nanoparticles. The nanoparticles significantly enhance the mechanical properties of the gel, acting as additional multifunctional non-covalent linkages between the polymer chains. High magnetization of the cobalt ferrite nanoparticles provides to the gel a strong responsiveness to the magnetic field, even at rather small content of nanoparticles. It is demonstrated that labile cross-links in the polymer matrix impart to the hydrogel the ability of self-healing and reshaping as well as a fast response to the magnetic field. In addition, the gel shows pronounced pH sensitivity due to pH-cleavable cross-links. The possibility to use the multiresponsive gel as a magnetic-field-triggered actuator is demonstrated.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Remotely Self-Healable, Shapeable and pH-Sensitive Dual Cross-Linked Polysaccharide Hydrogels with Fast Response to Magnetic Field

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Hydrogels of this type are initiated by covalent crosslinking of polymer units via a crosslinker agent by applying various strategies: (1) reaction of a low molecular weight crosslinker agent (e.g., diacid chlorides, isocyanates, glutaraldehyde, etc.) with a single polymer unit [ 60 ]; (2) use of a crosslinked hybrid (polymer-polymer) network (HPN) [ 61 , 62 ], (3) photopolymerization using a photosensitive crosslinker agent [ 63 ]; (4) enzyme-catalyzed crosslinking processes [ 64 ]; or (5) the use of interpenetrating polymer networks (IPNs), where two or more polymers in the network are formed in such a way that one polymer is crosslinked in the presence of the other [ 65 ]. The crosslink points between polymer chains promote 3D network formation that affect the various physicochemical properties of the polymer (e.g., elasticity, viscosity, solubility, and stability) in an incremental way in accordance with the crosslink density and the crystalline nature of the formed hydrogel structure.…”

Section: Fabrication Of Bio-based Hydrogelsmentioning

confidence: 99%

A Review on the Design and Hydration Properties of Natural Polymer-Based Hydrogels

2021

View full text Add to dashboard Cite

Hydrogels are hydrophilic 3D networks that are able to ingest large amounts of water or biological fluids, and are potential candidates for biosensors, drug delivery vectors, energy harvester devices, and carriers or matrices for cells in tissue engineering. Natural polymers, e.g., cellulose, chitosan and starch, have excellent properties that afford fabrication of advanced hydrogel materials for biomedical applications: biodegradability, biocompatibility, non-toxicity, hydrophilicity, thermal and chemical stability, and the high capacity for swelling induced by facile synthetic modification, among other physicochemical properties. Hydrogels require variable time to reach an equilibrium swelling due to the variable diffusion rates of water sorption, capillary action, and other modalities. In this study, the nature, transport kinetics, and the role of water in the formation and structural stability of various types of hydrogels comprised of natural polymers are reviewed. Since water is an integral part of hydrogels that constitute a substantive portion of its composition, there is a need to obtain an improved understanding of the role of hydration in the structure, degree of swelling and the mechanical stability of such biomaterial hydrogels. The capacity of the polymer chains to swell in an aqueous solvent can be expressed by the rubber elasticity theory and other thermodynamic contributions; whereas the rate of water diffusion can be driven either by concentration gradient or chemical potential. An overview of fabrication strategies for various types of hydrogels is presented as well as their responsiveness to external stimuli, along with their potential utility in diverse and novel applications. This review aims to shed light on the role of hydration to the structure and function of hydrogels. In turn, this review will further contribute to the development of advanced materials, such as “injectable hydrogels” and super-adsorbents for applications in the field of environmental science and biomedicine.

show abstract

“…Using MNPs as the crosslinking agent, the drawback of possible release of MNPs from the hydrogel to the external environment through diffusion was overcome. [224] developed ß-cyclodextrin/cellulose hydrogel beads for drug delivery, which exhibited rapid swelling-deswelling properties under an external magnetic field (EMF) to remotely control drug release. The efficiency of the hydrogel in the stepwise drug release dose and rate can be controlled by switching on-off the EMF and by adjusting the MNPs concentration.…”

Section: Maps For Drug Deliverymentioning

confidence: 99%

Tuning the Cell and Biological Tissue Environment through Magneto-Active Materials

et al. 2021

View full text Add to dashboard Cite

This review focuses on novel applications based on multifunctional materials to actuate biological processes. The first section of the work revisits the current knowledge on mechanically dependent biological processes across several scales from subcellular and cellular level to the cell-collective scale (continuum approaches). This analysis presents a wide variety of mechanically dependent biological processes on nervous system behaviour; bone development and healing; collective cell migration. In the second section, this review presents recent advances in smart materials suitable for use as cell substrates or scaffolds, with a special focus on magneto-active polymers (MAPs). Throughout the manuscript, both experimental and computational methodologies applied to the different treated topics are reviewed. Finally, the use of smart polymeric materials in bioengineering applications is discussed.

show abstract

Smart cellulose-derived magnetic hydrogel with rapid swelling and deswelling properties for remotely controlled drug release

Cited by 58 publications

References 51 publications

Remotely Self-Healable, Shapeable and pH-Sensitive Dual Cross-Linked Polysaccharide Hydrogels with Fast Response to Magnetic Field

Remotely Self-Healable, Shapeable and pH-Sensitive Dual Cross-Linked Polysaccharide Hydrogels with Fast Response to Magnetic Field

A Review on the Design and Hydration Properties of Natural Polymer-Based Hydrogels

Tuning the Cell and Biological Tissue Environment through Magneto-Active Materials

Contact Info

Product

Resources

About