Smart -borneol-loaded hierarchical hollow polymer nanospheres with antipollution and antibacterial capabilities

Song, Wenliang; Zhang, Mingxin; Huang, Xinyi; Chen, B.; Ding, Yaqiong; Zhang, Yi-Shuo; Yu, Deng‐Guang; Kim, Il

doi:10.1016/j.mtchem.2022.101252

Cited by 37 publications

(43 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this nano era, more and more “top-down” and “bottom-up” techniques are developed for bioengineering and biotechnology, accompanied with a series of novel functional materials such as hydrogels and new types of polymers ( Li et al, 2022b ; Zhang et al, 2022b ; Wang et al, 2022c ; Wang et al, 2022d Song et al, 2022 ; Wang and Feng, 2022 ; Zhu et al, 2022 ) and even inorganic nanoparticles ( Tang et al, 2022b ; Chen et al, 2022c ; Wu et al, 2022 ). The present protocols showed a frontier, in which the combination of a top-down electrospinning and a bottom-up of molecular self-emulsifying was explored to fabricate biomedical materials for resolving one of the most difficult challenges, i.e.…”

Section: Resultsmentioning

confidence: 99%

Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel

Ge¹,

Ding

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The poor solubility of numerous drugs pose a long-existing challenge to the researchers in the fields of pharmaceutics, bioengineering and biotechnology. Many “top-down” and “bottom-up” nano fabrication methods have been exploited to provide solutions for this issue. In this study, a combination strategy of top-down process (electrospinning) and bottom-up (self-emulsifying) was demonstrated to be useful for enhancing the dissolution of a typical poorly water-soluble anticancer model drug (paclitaxel, PTX). With polyvinylpyrrolidone (PVP K90) as the filament-forming matrix and drug carrier, polyoxyethylene castor oil (PCO) as emulsifier, and triglyceride (TG) as oil phase, Both a single-fluid blending process and a coaxial process were utilized to prepare medicated nanofibers. Scanning electron microscope and transmission electron microscope (TEM) results clearly demonstrated the morphology and inner structures of the nanofibers. The lipid nanoparticles of emulsions after self-emulsification were also assessed through TEM. The encapsulation efficiency (EE) and in vitro dissolution tests demonstrated that the cores-shell nanofibers could provide a better self-emulsifying process int terms of a higher EE and a better drug sustained release profile. Meanwhile, an increase of sheath fluid rate could benefit an even better results, suggesting a clear process-property-performance relationship. The protocols reported here pave anew way for effective oral delivery of poorly water-soluble drug.

show abstract

Section: Resultsmentioning

confidence: 99%

Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel

Ge¹,

Ding

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Terpene-modified polysiloxane-based polyurethane was also developed to improve mechanical properties of waterborne polyurethane [ 39 ]. Moreover, hyper-cross-linked porous polymers loaded with L-borneol with interesting antibacterial and antipollution properties have been prepared as well [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of Polyurethane Foams Additivated with Terpenes from a Bio-Based Polyol

et al. 2023

View full text Add to dashboard Cite

Water-blown polyurethane (PU) foams were prepared by bio-polyols from epoxidized linseed oils and caprylic acid in combination with toluene diisocianate (TDI). A series of terpenes (menthol, geraniol, terpineol, and borneol), natural compounds with recognized antibacterial properties, were included in the starting formulations to confer bactericidal properties to the final material. Foams additivated with Irgasan®, a broad-spectrum antimicrobial molecule, were prepared as reference. The bactericidal activity of foams against planktonic and sessile E. coli (ATCC 11229) and S. aureus (ATCC 6538) was evaluated following a modified AATCC 100-2012 static method. Menthol-additivated foams showed broad-spectrum antibacterial activity, reducing Gram+ and Gram− viability by more than 60%. Foams prepared with borneol and terpineol showed selective antibacterial activity against E. coli and S. aureus, respectively. NMR analysis of foams leaking in water supported a bactericidal mechanism mediated by contact killing rather than molecule release. The results represent the proof of concept of the possibility to develop bio-based PU foams with intrinsic bactericidal properties through a simple and innovative synthetic approach.

show abstract

“…On the contrary, highly hydrophobic fluorine-rich POPs were also prepared [ 21 , 22 ] and applied to capture the vapour of non-polar hydrocarbons and fluorinated compounds. Application-interesting POPs with ionic [ 20 , 23 ], luminescent [ 24 ], chiral [ 25 , 26 ], and other groups [ 27 , 28 ] were also reported in the literature. Unlike inorganic porous materials (zeolites, molecular sieves) or MOF-type materials, POPs are mostly highly stable in an aqueous environment, even in the presence of acids, bases, and salts.…”

Section: Introductionmentioning

confidence: 99%

Combining Polymerization and Templating toward Hyper-Cross-Linked Poly(propargyl aldehyde)s and Poly(propargyl alcohol)s for Reversible H2O and CO2 Capture and Construction of Porous Chiral Networks

et al. 2023

View full text Add to dashboard Cite

Two series of hyper-cross-linked microporous polyacetylene networks containing either -[CH=C(CH=O)]- or -[CH=C(CH2OH)]- monomeric units are reported. Networks are prepared by chain-growth copolymerization of acetal-protected propargyl aldehyde and acetal-protected propargyl alcohol with a 1,3,5-triethynylbenzene cross-linker followed by hydrolytic deprotection/detemplating. Deprotection not only liberates reactive CH=O and CH2OH groups in the networks but also modifies the texture of the networks towards higher microporosity and higher specific surface area. The final networks with CH=O and CH2OH groups attached directly to the polyene main chains of the networks have a specific surface area from 400 to 800 m2/g and contain functional groups in a high amount, up to 9.6 mmol/g. The CH=O and CH2OH groups in the networks serve as active centres for the reversible capture of CO2 and water vapour. The water vapour capture capacities of the networks (up to 445 mg/g at 297 K) are among the highest values reported for porous polymers, making these materials promising for cyclic water harvesting from the air. Covalent modification of the networks with (R)-(+)-3-aminopyrrolidine and (S)-(+)-2-methylbutyric acid enables the preparation of porous chiral networks and shows networks with CH=O and CH2OH groups as reactive supports suitable for the anchoring of various functional molecules.

show abstract

Smart -borneol-loaded hierarchical hollow polymer nanospheres with antipollution and antibacterial capabilities

Cited by 37 publications

References 65 publications

Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel

Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel

Antibacterial Properties of Polyurethane Foams Additivated with Terpenes from a Bio-Based Polyol

Combining Polymerization and Templating toward Hyper-Cross-Linked Poly(propargyl aldehyde)s and Poly(propargyl alcohol)s for Reversible H2O and CO2 Capture and Construction of Porous Chiral Networks

Contact Info

Product

Resources

About