Smart biomaterial-based systems for intrinsic stimuli-responsive chronic wound management

Alves, Pedro M.; Barrias, Cristina C.; Gomes, Paula; Martins, M. Cristina L.

doi:10.1016/j.mtchem.2021.100623

Cited by 20 publications

(18 citation statements)

References 111 publications

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“…Chitosan possesses several reactive functional groups (hydroxyls and amines) amenable to participate, directly or indirectly, in a wide range of [bio]functionalization, and/or cross-linking reactions. , Besides possessing mild antimicrobial activity, chitosan can also act as a sensitizer to potentiate the antimicrobial activity of other molecules, including antimicrobial peptides (AMP). , The covalent conjugation of AMP onto chitosan may improve its bactericidal properties, allowing, for instance, the fabrication of coatings to address medical devices-related infections , or to fight infection in biofilms established in highly proteolytic environments, such as skin chronic wounds, where covalent conjugation may protect AMP from enzymatic degradation …”

Section: Introductionmentioning

confidence: 99%

Thiol–Norbornene Photoclick Chemistry for Grafting Antimicrobial Peptides onto Chitosan to Create Antibacterial Biomaterials

Alves

Pereira

Costa

et al. 2022

ACS Appl. Polym. Mater.

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Covalent conjugation of antimicrobial peptides (AMP) is considered an effective approach to overcome their potential degradation in vivo. As the high cost of AMP-based therapies is one of the major hurdles toward their clinical application, it is urgently needed to explore high yield reactions. Herein, the highly efficient thiol–norbornene photoclick chemistry (TNPC) was explored for AMP grafting onto chitosan. Norbornenes were introduced onto chitosan (NorChit) in an aqueous/organic system, followed by UV-triggered conjugation of N- and C-terminus cysteine-modified Dhvar5 (NorChit-Dhvar5). Up to 0.38 norbornene groups per chitosan repeating unit and up to 43% conjugation yield in NorChit-Nt-Dhvar5 (80 μmol of Dhvar5/g) were achieved, while in NorChit-Ct-Dhvar5 conjugation yield was 30% (55 μmol of Dhvar5/g). Finally, NorChit-Dhvar5 ultrathin films showed up to a 35% reduction of total adhered Gram-positive Staphylococcus epidermidis and increased the adhesion and killing of Gram-negative Pseudomonas aeruginosa compared to unmodified chitosan. Moreover, NorChit-Dhvar5 was noncytotoxic to human neonatal dermal fibroblasts, according to ISO 10993-1. Overall, our findings indicate TNPC as a high yield strategy for AMP grafting onto norbornene-functionalized biopolymers toward the fabrication of antibacterial biomaterials.

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Section: Introductionmentioning

confidence: 99%

Thiol–Norbornene Photoclick Chemistry for Grafting Antimicrobial Peptides onto Chitosan to Create Antibacterial Biomaterials

Alves

Pereira

Costa

et al. 2022

ACS Appl. Polym. Mater.

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“…Regarding enzymecontrolled biomaterials, although they successfully control the drug release, the elevated enzyme levels may increase the incidence of the exposure of biomolecules to enzymatic attacks. Also, achieving a well-controlled drug release is not easy as all smart materials suffer from an initial burst release when the specific stimulus is present so attaining a specific dosage at a specific time is difficult [156]. The literature includes several examples highlighting the use of smart polymers in the field of tissue engineering as briefly illustrated in Table III.…”

Section: Smart Polymers (Stimuli-responsive)mentioning

confidence: 99%

Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review

2022

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Tissue engineering has emerged as an interesting field nowadays; it focuses on accelerating the auto-healing mechanism of tissues rather than organ transplantation. It involves implanting an In Vitro cultured initiative tissue or a scaffold loaded with tissue regenerating ingredients at the damaged area. Both techniques are based on the use of biodegradable, biocompatible polymers as scaffolding materials which are either derived from natural (e.g. alginates, celluloses, and zein) or synthetic sources (e.g. PLGA, PCL, and PLA). This review discusses in detail the recent applications of different biomaterials in tissue engineering highlighting the targeted tissues besides the in vitro and in vivo key findings. As well, smart biomaterials (e.g. chitosan) are fascinating candidates in the field as they are capable of elucidating a chemical or physical transformation as response to external stimuli (e.g. temperature, pH, magnetic or electric fields). Recent trends in tissue engineering are summarized in this review highlighting the use of stem cells, 3D printing techniques, and the most recent 4D printing approach which relies on the use of smart biomaterials to produce a dynamic scaffold resembling the natural tissue. Furthermore, the application of advanced tissue engineering techniques provides hope for the researchers to recognize COVID-19/host interaction, also, it presents a promising solution to rejuvenate the destroyed lung tissues. Graphical abstract

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“…For example, Martins et al provided a detailed discussion about smart dressings responsive to endogenous stimuli (pH, temperature, enzyme levels, and reactive oxygen species). 26 Cheng et al summarized smart bioadhesives for wound healing and closure. 27 Unfortunately, a detailed summary and systematic analysis about the research progress of multifunctional wound dressings in recent years is still lacking.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Construction of multifunctional wound dressings with their application in chronic wound treatment

Long

Liu

et al. 2022

Biomater. Sci.

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Smart biomaterial-based systems for intrinsic stimuli-responsive chronic wound management

Cited by 20 publications

References 111 publications

Thiol–Norbornene Photoclick Chemistry for Grafting Antimicrobial Peptides onto Chitosan to Create Antibacterial Biomaterials

Thiol–Norbornene Photoclick Chemistry for Grafting Antimicrobial Peptides onto Chitosan to Create Antibacterial Biomaterials

Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review

Construction of multifunctional wound dressings with their application in chronic wound treatment

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