Smart bandage with wireless connectivity for uric acid biosensing as an indicator of wound status

Kassal, Petar; Kim, Jayoung; Kumar, Rajan; Araújo, Wanderley Pereira de; Steinberg, Ivana Murković; Steinberg, Matthew D.; Wang, Joseph

doi:10.1016/j.elecom.2015.03.018

Cited by 260 publications

(195 citation statements)

References 26 publications

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“…In the conventional design, the electrochemical measurements were often performed by potentiostat detecting circuits, while smartphone was only used as a platform to control and display the measurement. Data communications between smartphone and detecting device were often through wire or wireless ways, such as audio jack, Bluetooth, and NFC (Nemiroski et al, 2014;Kassal et al, 2015;Zhang et al, 2015). Generally, the wire communications had a good universality for different generation of mobile phone, while the wireless communications can provide a better mobility for sensor instruments.…”

Section: Future Perspectivesmentioning

confidence: 99%

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Biosensors and bioelectronics on smartphone for portable biochemical detection

Zhang

Liu

2016

Biosensors and Bioelectronics

546

216

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Section: Future Perspectivesmentioning

confidence: 99%

“…For instance, Kassal et al reported a sensor bandage with wireless connectivity to smartphone for wound monitoring (Kassal et al, 2015). The system…”

Section: Smartphone-based Nfc Sensormentioning

confidence: 99%

Biosensors and bioelectronics on smartphone for portable biochemical detection

Zhang

Liu

2016

Biosensors and Bioelectronics

546

216

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“…Long-standing hyperuricemia also contributes to gout, which is caused by the nucleation and growth of monosodium urate crystals in tissues in and around the joints following the saturation threshold of UA in serum [13]. More recently, UA has also been identified as a key biomarker in wounds, indicating the severity of a wound or presence of infection with increasing concentrations [14].…”

Section: Introductionmentioning

confidence: 98%

“…Recently, Wang and coworkers reported an elegant "smart bandage" UA biosensor capable of indicating UA release from a wound through the detection of H 2 O 2 via Prussian blue mediation with a carbon coating [14]. One popular strategy for designing amperometric biosensing schemes remains the modification of electrodes with multiple layers of functional materials.…”

Section: Introductionmentioning

confidence: 99%

Layer-by-layer design and optimization of xerogel-based amperometric first generation biosensors for uric acid

Conway

Lambertson

Schwarzmann

et al. 2016

Journal of Electroanalytical Chemistry

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a b s t r a c tA layer-by-layer (LbL) strategy of modifying an electrode with a specific combination of polymeric and xerogel materials is used to create an effective first generation biosensor for uric acid (UA) -a clinically relevant molecule implemented in pregnancy induced hypertension (PIH) diagnosis, a condition that can lead to a serious disorder called preeclampsia. In addition to offering a new, promising sensor for UA, this study represents significant progress for amperometric biosensor development since the strategy and materials employed were successfully and readily adapted from a glucose biosensor model scheme and used for the effective detection of UA, a fundamentally different molecule compared to glucose. Specifically, each of four, functional modifying layers (outer polyurethane (PU) selective membrane, the inner selective electropolymer, and the xerogel bi-layer) are systematically investigated and tailored for UA permeability and interferent discrimination. The role of PU hydrophobicity and its UA permeability are established while the enzyme-doped and outer diffusional xerogel layers are evaluated for uricase (UOx) species/loading and silane precursor dependence, respectively. LbL systematic evaluation reveals the specific combination of hydroxyl-methyl triethoxy silane (HMTES) xerogels, a polyluminol-aniline electropolymer, and 100% hydrophilic polyurethane yields impressive uric acid sensing performance: effective sensitivity (0.8 nA/μM), linear response across physiologically relevant UA concentrations (100-700 μM), fast response times (~10 s), low limits of detection (b 10 μM), and selectivity against most common interferents. Toward the specific application of PIH risk assessment, the optimized sensor exhibited 10 day stability as well as effective shelf-life exceeding 35 days. The presented system rivals or exceeds UA biosensor performance found in the literature and offers the possibility of miniaturization for in situ or in vivo remote diagnostic sensing. The successful adaptation suggests that the strategy and materials may be applicable to detecting/monitoring other medically significant molecules via sensor development.

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“…However, new non-invasive chemical sensors are critically desired to expand the scope of wearable sensor technology beyond vital signs and hence to obtain a more comprehensive information about a wearer's health and performance status. 1,3,11 Several research groups have recently addressed this gap by introducing wearable chemical sensors for monitoring of metabolites, such as a lactate 12–14 , glucose, 15,16 or uric acid, 17,18 and electrolytes, such as sodium, 19,20 potassium 14,20 or pH 21 . Widespread acceptance of wearable sensor technology requires the creation of products that can be easily integrated into an individual's lifestyle Most wearable chemical sensors have relied on sweat analysis in connection to flexible and temporary tattoo-like devices, 3,22,23 head bands, 24 or wrist bands.…”

Section: Introductionmentioning

confidence: 99%

Eyeglasses based wireless electrolyte and metabolite sensor platform

et al. 2017

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The demand for wearable sensors has grown rapidly in recent years, with increasing attention being given to epidermal chemical sensing. Here, we present the first example of a fully-integrated eyeglasses wireless multiplexed chemical sensing platform capable of real-time monitoring of sweat electrolytes and metabolites. The new concept has been realized by integrating an amperometric lactate biosensor and a potentiometric potassium ion-selective electrode on the two nose bridge pads of the glasses and interfacing them to a wireless electronic backbone placed on the glasses arms. Simultaneous real-time monitoring of sweat lactate and potassium levels with no apparent cross-talk is demonstrated along with wireless signal transduction. The electrochemical sensors were screen printed on a polyethylene terephthalate (PET) stickers and placed on each side of the glasses nose pads in order to monitor sweat metabolites and electrolytes. The electronic backbone on the arms of the glasses frame offers control of the amperometric and potentiometric transducers and enables Bluetooth wireless data transmission to the host device. The new glasses system offers an interchangeable-sensor feature in connection to variety of different nose-bridge amperometric and potentiometric sensor stickers. For example, the lactate bridge-pad sensor was replaced with a glucose one to offer convenient monitoring of sweat glucose. Such fully-integrated wireless “Lab-on-a-Glass” multiplexed biosensor platform can be readily expanded for the simultaneous monitoring of additional sweat electrolytes and metabolites.

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Smart bandage with wireless connectivity for uric acid biosensing as an indicator of wound status

Cited by 260 publications

References 26 publications

Biosensors and bioelectronics on smartphone for portable biochemical detection

Biosensors and bioelectronics on smartphone for portable biochemical detection

Layer-by-layer design and optimization of xerogel-based amperometric first generation biosensors for uric acid

Eyeglasses based wireless electrolyte and metabolite sensor platform

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