Smart AS1411-aptamer conjugated pegylated PAMAM dendrimer for the superior delivery of camptothecin to colon adenocarcinoma in vitro and in vivo

Alibolandi, Mona; Taghdisi, Seyed Mohammad; Ramezani, Pouria; Shamili, Fazileh Hosseini; Farzad, Sara Amel; Abnous, Khalil; Ramezani, Mohammad

doi:10.1016/j.ijpharm.2017.01.044

Cited by 132 publications

(65 citation statements)

References 47 publications

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“…It is widely used in the biomedical field as carrier systems for drugs, genes, and vaccines, in drug release and targeted drug delivery (Alibolandi et al, 2017;Sharma et al, 2017). Rely on their large numbers of terminal functional groups, PAMAM can greatly increase the quantity of attached various biomolecules such as antibody, enzyme, or aptamer, and consequently improve sensitivity of detection (Akter, Jeong, Lee, Choi, & Rahman, 2017;Malvano, Albanese, Pilloton, & Matteo, 2017;Miodek, Omrani, Khoder, & Youssoufi, 2016).…”

Section: Introductionmentioning

confidence: 99%

A signal-enhanced lateral flow strip biosensor for ultrasensitive and on-site detection of bisphenol A

Peng

Kang

Pang

et al. 2017

Food and Agricultural Immunology

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A signal-enhanced lateral flow strip biosensor has been constructed for ultrasensitive and on-site visual detection of bisphenol A (BPA). The signal amplification principle is based on the capacity of binding a large number of antibody-assembled gold nanoparticle (AuNP-antibody) conjugates of the poly amidoamine (PAMAM), which bears a multitude of amino groups. This signal-enhanced method could achieve BPA detection at 10 ppb based on naked eye visual observation, which represents an at least 50-fold improvement of the sensitivity of a traditional method without PAMAM. Moreover, good linearity was observed in the range from 2 to 100 ppb after quantitative analysis using the ImageJ software. This signal amplification method could be adopted as a potential generous technique in different fields. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

A signal-enhanced lateral flow strip biosensor for ultrasensitive and on-site detection of bisphenol A

Peng

Kang

Pang

et al. 2017

Food and Agricultural Immunology

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“…The same authors designed and developed PEGylated G5 PAMAM dendrimers loaded with camptothecin (CPT; a topoisomerase inhibitor used as an anticancer agent) and surface grafted with AS1411 anti-nucleolin aptamers for site-specific targeting to colorectal cancer cells overexpressing nucleolin receptors ( Figure 5) [26]. One of the problems of the drug delivery system is the inability to discriminate target cells from nontarget cells, which could result in off-target delivery.…”

Section: Dendrimer-aptamer Bioconjugates In Nanomedicinementioning

confidence: 99%

Dendrimer– and polymeric nanoparticle–aptamer bioconjugates as nonviral delivery systems: a new approach in medicine

Mignani

Shi

Ceña

et al. 2020

Drug Discovery Today

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Research Highlights Dendrimer-aptamer conjugates Polymer-aptamer conjugates  Delivery aptamers Cancer Aptamers are RNA or DNA oligonucleotides interacting to form unique 3D target conformations with high affinity and specificity, and are emerging as a powerful class of ligands for therapeutic applications. In addition, dendrimers are well-defined nano-sized symmetric polymeric molecules. In this review, we provide an analysis of the use of dendrimers modified with aptamers as nonviral vectors to specifically target tumor cells. Various anticancer agents have been encapsulated with dendrimers complexing with aptamers, including epirubicin, camptothecin, Bcl-xL short hairpin (sh)RNA, and 5-fluorouracil rhodamine-labeled dextran. Other types of polymeric nanoparticle (NP)-aptamer bioconjugates have also been developed and loaded with Pt(IV) derivatives, to target specific tumor cells. Keywords: dendrimer space; aptamers; polymeric nanoparticles; drug delivery. Teaser: We discuss the development of dendrimer-and polymeric nanoparticle-aptamer bioconjugates as a new approach in medicine Aptamer-based tools for therapeutic monitoring for precision therapy Aptamer comes from the Latin 'aptare' meaning to fit together or join, and from the Greek 'meros' meaning part. A nucleic acid aptamer is a short chain of artificial oligonucleotides of RNA or single-stranded DNA with a variable region of ~40-100 nucleotide bases [1]. Their unique, flexible 3D structure, and their high affinity and specificity with ligand-binding capabilities, are strongly related to their sequence. These important characteristics increase their ability to differentiate between targets. In contrast to antibodies, aptamers can bind to functional domains of their cognate target protein (e.g., substrate binding pockets and allosteric sites) ( Figure 1) [2]. Aptamers are considered to be 'smart ligands' and are often named 'nucleic acid antibodies'. The binding between aptamers and user-defined targets occurs through electrostatic interactions, which result in their versatility. The strong binding affinity and exceptional specificity induces a nano-or pico-molar dissociation constant (Kd). Their targets vary from small ions, such as Zn 2+, and large proteins, such as coagulation factor VIII, to whole cells, viruses, and tissues [3]. J o u r n a l P r e -p r o o f

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“…However, upon UV irradiation of the nanoparticles for 5 min, 10 min and 15 min, the polyethylenimine molecules on the surface were cleaved by the free radicals (OH· and O 2 ·) generated by TiO 2 and released 20.1%, 37.2%, and 73.4% of the paclitaxel over 3 h, respectively. Nanoparticles made of gold in rod, shell, or hollow sphere shape, and carbon nanotubes can absorb NIR light and generate heat for photothermally targeted drug delivery [26]. This technology was also mentioned in the above Thermoresponsive Nanomaterials Section, and can be used to deliver drugs in deep tissues because NIR can penetrate through 10 cm with minimal absorption or scattering by water and tissues [26,95–97].…”

Section: Light-responsive Nanomaterialsmentioning

confidence: 99%

“…Nanoparticles made of gold in rod, shell, or hollow sphere shape, and carbon nanotubes can absorb NIR light and generate heat for photothermally targeted drug delivery [26]. This technology was also mentioned in the above Thermoresponsive Nanomaterials Section, and can be used to deliver drugs in deep tissues because NIR can penetrate through 10 cm with minimal absorption or scattering by water and tissues [26,95–97]. Doxorubicin-loaded hollow gold nanospheres were administered intravenously to mice bearing Hey tumor and irradiation of the tumor area 24 h after injection using 808 nm NIR laser light resulted in rapid release and distribution of the doxorubicin in the treated area [96].…”

Section: Light-responsive Nanomaterialsmentioning

confidence: 99%

“…For instance, positively charged surfaces generally enhance nanoparticle cellular uptake [23–25]. PEGylation (the process of attaching polyethylene glycol (PEG) chains) of nanocarriers induces steric repulsion of blood opsonins and significantly increases the circulation time of nanomaterials [26]. The size of nanomaterials affects the biodistribution and cellular uptake of the nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Design strategies for physical-stimuli-responsive programmable nanotherapeutics

Sahle

Gulfam

Lowe

2018

Drug Discovery Today

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Nanomaterials that respond to externally applied physical stimuli such as temperature, light, ultrasound, magnetic field and electric field have shown great potential for controlled and targeted delivery of therapeutic agents. However, the body of literature on programming these stimuli-responsive nanomaterials to attain the desired level of pharmacologic responses is still fragmented and has not been systematically reviewed. The purpose of this review is to summarize and synthesize the literature on various design strategies for simple and sophisticated programmable physical stimuli-responsive nanotherapeutics.

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Smart AS1411-aptamer conjugated pegylated PAMAM dendrimer for the superior delivery of camptothecin to colon adenocarcinoma in vitro and in vivo

Cited by 132 publications

References 47 publications

A signal-enhanced lateral flow strip biosensor for ultrasensitive and on-site detection of bisphenol A

A signal-enhanced lateral flow strip biosensor for ultrasensitive and on-site detection of bisphenol A

Dendrimer– and polymeric nanoparticle–aptamer bioconjugates as nonviral delivery systems: a new approach in medicine

Design strategies for physical-stimuli-responsive programmable nanotherapeutics

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