‘Smart’ acid-degradable zinc-releasing silicate glasses

Chen, Xiaohui; Brauer, Delia S.; Karpukhina, Natalia; Waite, Richard; Barry, Matthew; McKay, Ian J.; Hill, Robert G.

doi:10.1016/j.matlet.2014.04.009

Cited by 30 publications

(34 citation statements)

References 19 publications

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“…The global reduction in the overall leaching activity with higher zinc concentration can also be explained by the fact that amorphous phases are usually more prone to ion leaching phenomena than crystalline phases [81]. Chen et al [46] incorporated ZnO (14 mol% -25 mol%) in silicate glasses of the composition (mol%) 44 -55% SiO 2 , 7% CaO, 5% K 2 O, 19% Na 2 O, 14 -25% ZnO and reported that glasses with low ZnO content (< 19 mol%) were amorphous while the glasses with higher ZnO content (> 21 mol%) contained small amounts of crystalline sodium zinc silicate. The results are related to the findings of Kamitakahara et al [46] who showed that the glass transition and crystallization temperatures of CaO-SiO 2 -P 2 O 5 -CaF 2 glass-ceramics decreased with increasing ZnO content up to 14.2 mol%.…”

Section: Structure Physical and Mechanical Propertiesmentioning

confidence: 99%

“…Chen et al [46] incorporated ZnO (14 mol% -25 mol%) in silicate glasses of the composition (mol%) 44 -55% SiO 2 , 7% CaO, 5% K 2 O, 19% Na 2 O, 14 -25% ZnO and reported that glasses with low ZnO content (< 19 mol%) were amorphous while the glasses with higher ZnO content (> 21 mol%) contained small amounts of crystalline sodium zinc silicate. The results are related to the findings of Kamitakahara et al [46] who showed that the glass transition and crystallization temperatures of CaO-SiO 2 -P 2 O 5 -CaF 2 glass-ceramics decreased with increasing ZnO content up to 14.2 mol%. These observations were similar to a recent study by Kapoor et al [45] wherein the addition of zinc to a system of CaO-MgO-ZnO-P 2 O 5 -SiO 2 -CaF 2 glasses gradually decreased the glass transition temperature from 752 to 718 ∘ C. This, in turn, translates in lowering the viscosity of the glasses and thereby, decreasing their crystallization temperatures as well.…”

Section: Structure Physical and Mechanical Propertiesmentioning

confidence: 99%

“…Rat bone marrow cells showed higher ALP activity and up-regulated osteogenic-related genes in zincincorporated coatings in comparison with zinc-free coatings. In addition, zinc is antimicrobial and plays a major role in wound healing [46]. Antimicrobial coatings for metallic implants can thus be developed based on this property of zinc.…”

Section: Biomedical Coatingsmentioning

confidence: 99%

“…Antimicrobial coatings for metallic implants can thus be developed based on this property of zinc. Chen et al [46] incorporated zinc in silicate glasses to be applied as coatings on stainless steel. The authors hypothesized that zinc present in the silicate glass system influences the ion release behavior of the glass ion response to the pH environment, wherein glasses are comparatively stable in neutral pH and they dissolve readily under acidic conditions.…”

Section: Biomedical Coatingsmentioning

confidence: 99%

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Zinc-containing bioactive glasses for bone regeneration, dental and orthopedic applications

Balasubramanian¹,

Strobel²,

Kneser³

et al. 2015

Biomedical Glasses

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Zinc is a vital and beneficial trace element found in the human body. Though found in small proportions, zinc performs a variety of functions in relation to the immune system, cell division, fertility and the body growth and maintenance. In particular, zinc is proven to be a necessary element for the formation, mineralization, development and maintenance of healthy bones. Considering this attractive attributes of zinc, recent research has widely focused on using zinc along with silicate-based bioactive glasses for bone tissue engineering applications. This paper reviews relevant literature discussing the significance of zinc in the human body, along with its ability to enhance antibacterial effects, bioactivity and distinct physical, structural and mechanical properties of bioactive glasses. In this context, even if the present analysis is not meant to be exhaustive and only representative studies are discussed, literature results confirm that it is essential to understand the properties of zinc-containing bioactive glasses with respect to their in vitro biological behavior, possible cytotoxic effects and degradation characteristics to be able to effectively apply these glasses in bone regeneration strategies. Topics attracting increasing research efforts in this field are elaborated in detail in this review, including a summary of the structural, physical, biological and mechanical properties of zinc-containing bioactive glasses. This paper also presents an overview of the various applications in which zinc-containing bioactive glasses are considered for use as bone tissue scaffolds, bone filling granules, bioactive coatings and bone cements, and advances and remaining challenges are highlighted.

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Section: Structure Physical and Mechanical Propertiesmentioning

confidence: 99%

Section: Structure Physical and Mechanical Propertiesmentioning

confidence: 99%

Section: Biomedical Coatingsmentioning

confidence: 99%

Section: Biomedical Coatingsmentioning

confidence: 99%

See 2 more Smart Citations

Zinc-containing bioactive glasses for bone regeneration, dental and orthopedic applications

Balasubramanian¹,

Strobel²,

Kneser³

et al. 2015

Biomedical Glasses

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“…The research done by Minser et al [23] shows that it is possible to obtain fully amorphous glass from the Na 2 OZnO-SiO 2 system if it contains the addition of ZnO in the amount of up to 30 % mol. The research on the glasses with the composition (100-x)SiO 2 -7CaO-5K 2 O-19Na 2 OxZnO done by Chen et al [24] indicates that adding over 19 mol% of ZnO causes their crystallization.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of zinc addition effect on thermal properties of silicate and phosphate glasses

Sułowska

Wacławska

Szumera

2015

J Therm Anal Calorim

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The aim of the study was an analysis of two groups of glasses from the SiO 2 -P 2 O 5 -K 2 O-CaO-MgO system with various content of network formers in the form of P 2 O 5 and SiO 2 , modified by the addition of ZnO. Their effect on glass-forming ability, glass transition effect, crystallization process and the kind of crystallizing phases was examined using DSC and XRD methods. It was observed that in both matrixes, the addition of ZnO decreases the glass transition temperature (T g ). The lower T g values observed in the phosphate matrix glasses and the accompanying higher values of the changes in molar heat capacity (Dc p ) in contrast to the silicate matrix glasses may be considered an indicator of the degree of the reconstruction of their amorphous structure, which facilitates the process of their crystallization. It was found that the crystallizing products of the silicate matrix glasses were silicates and phosphates whose structure contained zinc. In the phosphate matrix glasses, it was observed that zinc inhibited the crystallization of silicate phases.

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Bioactive Glasses

Jaimes¹,

Poologasundarampillai²,

Brauer³

2019

Kirk-Othmer Encyclopedia of Chemical Technology

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Bioactive silicate glasses release ions when in contact with physiological solutions, leading to the formation of a biomimetic apatite surface layer. This apatite layer allows for protein adhesion, cell attachment and proliferation, and, subsequently, formation of a strong interfacial bond between bioactive glass and bone. In addition, bioactive glasses degrade in vivo and are replaced by new bone, and they thus help to regenerate bone tissue. These reactions are possible owing to the highly disrupted silicate structure of bioactive glasses, containing large concentrations of modifier ions and nonbridging oxygen atoms. Bioactive glasses have been used clinically since the mid‐1980s, and they are used mainly to treat bone defects. However, their mineralizing properties have also resulted in them being used in oral care products for the treatment of sensitive teeth and the remineralization of enamel.

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‘Smart’ acid-degradable zinc-releasing silicate glasses

Cited by 30 publications

References 19 publications

Zinc-containing bioactive glasses for bone regeneration, dental and orthopedic applications

Zinc-containing bioactive glasses for bone regeneration, dental and orthopedic applications

Comparative study of zinc addition effect on thermal properties of silicate and phosphate glasses

Bioactive Glasses

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