SMARCD3 Overexpression Promotes Epithelial–Mesenchymal Transition in Gastric Cancer
Sun Yi Park,
Ji-Ho Park,
Jung Wook Yang
et al.
Abstract:This study investigates the role of SMARCD3 in gastric cancer by comparing its expression in signet ring cell (SRC) and well-differentiated (WD) groups within gastric cancer cell lines and tissues. We observed elevated SMARCD3 levels in the SRC group compared to the WD group. Functional analysis was conducted through both SMARCD3 knock-in and knock-out methods. Kaplan–Meier survival analysis indicated that higher SMARCD3 expression correlates with poorer overall survival in gastric cancer patients (HR 2.16, p … Show more
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