2021
DOI: 10.1016/j.jtho.2021.03.024
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SMARCA4 and Other SWItch/Sucrose NonFermentable Family Genomic Alterations in NSCLC: Clinicopathologic Characteristics and Outcomes to Immune Checkpoint Inhibition

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Cited by 57 publications
(63 citation statements)
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References 53 publications
(69 reference statements)
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“…As previously described, the co-mutation frequency of STK11 and KEAP1 significantly co-occurred [49,63,64]. Furthermore, STK11 and KEAP1 alterations frequently co-occur in 30% to 60% of SMARCA4-mutant NSCLCs [49,72].…”
Section: Stk11/lkb1 Alterations and Co-occurring Mutations: Prognosti...supporting
confidence: 67%
“…As previously described, the co-mutation frequency of STK11 and KEAP1 significantly co-occurred [49,63,64]. Furthermore, STK11 and KEAP1 alterations frequently co-occur in 30% to 60% of SMARCA4-mutant NSCLCs [49,72].…”
Section: Stk11/lkb1 Alterations and Co-occurring Mutations: Prognosti...supporting
confidence: 67%
“…On the other hand, a remarkable effect on ICI therapy received by patients with KRAS and TP53 mutation was seen that was compared to KRAS-SMARCA4 mutation or KRAS mutation alone, as this co-mutation facilitates T-cell infiltration and augments tumor immunogenicity, resulting in a high PD-L1 expression. This, in fact, further enhances the need to evaluate BRG1 IHC expression and molecular evaluation of co-mutations to predict the responders with NSCLC to immunotherapy [7,43,44].…”
Section: Prognostic and Predictive Management Issues In Smarca4-deficient Nsclcmentioning
confidence: 99%
“…The special relationship carried by KRAS-driven lung cancers with SMARCA4 loss was studied by some research groups [7,43,44]. As is already known, KRAS is a key oncogenic driver in lung adenocarcinomas, which is frequently observed in ever smokers and it is associated with a high TMB; hence, a subset of cases which carry other mutations may show a better response to ICI therapy.…”
Section: Prognostic and Predictive Management Issues In Smarca4-deficient Nsclcmentioning
confidence: 99%
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“…A few therapeutic molecules targeting these genomic alterations are under development, most are being tested in vitro but some are also being evaluated in clinical trials. ICIs have been found to be efficacious in patients with SMARCA4 mutated or rearranged tumors 138,139 . However, cases of hyper progression after administration of ICIs have also been reported in these tumors 139 .…”
Section: Other Gene Fusions In Nsclcmentioning
confidence: 99%