Smallpox Vaccination after a Bioterrorism-Based Exposure

Bicknell, William J.; James, Ken

doi:10.1086/376650

Cited by 6 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It concluded that postexposure vaccination reduced the clinical case rate by 50% when administered up to 5 days postexposure [32]. Concerns over the effectiveness of postexposure vaccination have been raised by others [33,34].…”

Section: Should Preemptive Vaccination Be Offered To the Public?mentioning

confidence: 99%

Rethinking Smallpox

Weiss¹,

Weiss²,

Mathisen³

et al. 2004

CLIN INFECT DIS

View full text Add to dashboard Cite

The potential consequences of a competently executed smallpox attack have not been adequately considered by policy makers. The possibility of release of an aerosolized and/or bioengineered virus must be anticipated and planned for. The transmission and infectivity of variola virus are examined. Arguments for and against pre-event vaccination are offered. The likely morbidity and mortality that would ensue from implementation of a mass pre-event vaccination program, within reasonable boundaries, are known. The extent of contagion that could result from an aerosolized release of virus is unknown and may have been underestimated. Pre-event vaccination of first responders is urged, and voluntary vaccination programs should be offered to the public. Two defenses against a vaccine-resistant, engineered variola virus are proposed for consideration. Methisazone, an overlooked drug, is reported to be effective for prophylaxis only. The extent of reduction in the incidence of smallpox with use of this agent is uncertain. It is useless for treatment of clinical smallpox. N-100 respirators (face masks) worn by uninfected members of the public may prevent transmission of the virus.

show abstract

Section: Should Preemptive Vaccination Be Offered To the Public?mentioning

confidence: 99%

Rethinking Smallpox

Weiss¹,

Weiss²,

Mathisen³

et al. 2004

CLIN INFECT DIS

View full text Add to dashboard Cite

show abstract

An update on smallpox vaccine candidates and their role in bioterrorism related vaccination strategies

Wiser

Balicer

Cohen

2007

Vaccine

View full text Add to dashboard Cite

Defending against smallpox: a focus on vaccines

Voigt

Kennedy

Poland

2016

Expert Review of Vaccines

View full text Add to dashboard Cite

Smallpox has shaped human history, from the earliest human civilizations well into the 20th century. With high mortality rates, rapid transmission, and serious long-term effects on survivors, smallpox was a much-feared disease. The eradication of smallpox represents an unprecedented medical victory for the lasting benefit of human health and prosperity. Concerns remain, however, about the development and use of the smallpox virus as a biological weapon, which necessitates the need for continued vaccine development. Smallpox vaccine development is thus a much-reviewed topic of high interest. This review focuses on the current state of smallpox vaccines and their context in biodefense efforts.

show abstract

Smallpox Vaccination after a Bioterrorism-Based Exposure

Cited by 6 publications

References 2 publications

Rethinking Smallpox

Rethinking Smallpox

An update on smallpox vaccine candidates and their role in bioterrorism related vaccination strategies

Defending against smallpox: a focus on vaccines

Contact Info

Product

Resources

About