Smallest lectin-like peptide identified from the skin secretion of an endemic frog, Hydrophylax bahuvistara

Abstract

Lectins are sugar-binding proteins and considered as attractive candidates for drug delivery and targeting. Here, we report the identification of the smallest lectin-like peptide (odorranalectin HYba) from the skin secretion of Hydrophylax bahuvistara which is being the shortest lectin-like peptide identified so far from the frog skin secretion, with 15 amino acid residues. The peptide is the first report from an Indian frog and lacks antimicrobial activity but strongly agglutinate intact human erythrocytes. The sequences at the L-fucose recognizing region is conserved as in other lectins reported from frog skin secretion and could be exploited for specificity and drug targeting properties.

Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art

“…Nonetheless, their applicability to lectin engineering remains largely limited when compared to other functional proteins such as enzymes [ 319 ]. Furthermore, efforts have been made to develop small lectin-like peptides for drug targeting, as normal lectins with a molecular weight of more than 10 KD can result in toxicity and immunogenicity [ 320 , 321 ].…”

Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41

“…Similarly, the β-galactose-specific lectin from the polychaete marine worm Chaetopterus variopedatus has also been shown to exert anti-HIV-1 activity by blocking HIV-1 entry into cells . However, lectins tend to weigh over 10 kDa, resulting in unavoidable toxicity or immunogenicity, limiting their clinical development and application. − Therefore, the discovery of small, specific lectins would be highly desirable. While small-size lectins such as retrocyclin-1, Selenocosmia huwena lectin-I, and odorranalectin have been discovered, only a few have exhibited anti-HIV capacity. − …”