Smaller, denser LDL particles are not a risk factor for cardiovascular disease in healthy nonagenarian women of the Cremona Population Study

Ruotolo, Giacomo; Tettamanti, Cristina; Garancini, Maria Paola; Ragogna, Francesca; Derosa, Giuseppe; Nardecchia, L; Parlato, F.; Pozza, G.

doi:10.1016/s0021-9150(98)00110-5

Cited by 14 publications

(7 citation statements)

References 29 publications

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“…Recent results, however, appear to indicate that the association between LDL size and CHD is weaker in older individuals and in other ethnic groups [46][47][48][49]. In contrast, the association may be stronger in young women [50].…”

Section: Familial Forms Of Hypertriglyceridemiamentioning

confidence: 99%

Triglyceride, small, dense low-density lipoprotein, and the atherogenic lipoprotein phenotype

Austin

2000

Curr Atheroscler Rep

103

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This review provides an overview of the recent data evaluating triglyceride and low-density lipoprotein (LDL) size, two highly interrelated, genetically influenced, risk factors for cardiovascular disease (CVD). An examination of new epidemiologic studies continues to demonstrate that plasma triglyceride levels predict CVD. The first prospective study of the familial forms of hypertriglyceridemia has shown that relatives in familial-combined hyperlipidemia families are at increased risk for CVD mortality and that triglyceride levels predicted 20-year, CVD mortality among relatives in familial hypertriglyceridemia families. A meta-analysis of three, large-scale, prospective studies in men, and the first study to examine the correlation of LDL particle size distribution and vascular changes measured by B-mode ultrasound, add to growing evidence that small, dense LDL is atherogenic. Quantitative genetic analysis has recently shown substantial pleiotropic (common) genetic effects on triglyceride and LDL size. At least part of this may be explained by variation at the cholesterol ester transfer protein locus on chromosome 16, possibly through its role in reverse cholesterol transport. Taken together, these data provide new insights into the importance of triglyceride and LDL particle size for understanding genetic susceptibility to cardiovascular disease and its prevention.

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Section: Familial Forms Of Hypertriglyceridemiamentioning

confidence: 99%

Triglyceride, small, dense low-density lipoprotein, and the atherogenic lipoprotein phenotype

Austin

2000

Curr Atheroscler Rep

103

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“…The feasibility of the identification of small, dense LDL particles as independent predictors of coronary artery disease risk in population studies remains questioned. Few data are available on population‐based studies and even less on subjects living in the Mediterranean area, where a low rate of cardiovascular mortality occurs [13–20]. This cardiovascular protection could result from genetic reasons but a major role must be attributed to environmental factors and in particular to the typical diet particularly helpful in terms of health effects.…”

Section: Introductionmentioning

confidence: 99%

“…However, it is incorrect to consider Mediterranean populations as a whole, but multiple local situations, also geographically nearby, differ for genetic background, traditions and, often, alimentary habits. Regarding the Italian population, only two reports are available to date on the LDL peak particle size distribution [19,20]; however, both of them are relative to subjects living in the northern part of the country, where a progressive increase of consumption of meat, fats, milk and diary products and sugar has been found. Thus, we decided to evaluate the situation in an island village of southern Italy, preserving old traditions in terms of diet and life‐style.…”

Section: Introductionmentioning

confidence: 99%

Low‐density‐lipoprotein peak particle size in a Mediterranean population

Rizzo

Barbagallo

Severino

et al. 2003

Eur J Clin Investigation

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In this population, which appears to be somewhat protected by premature coronary artery disease, a low prevalence of the LDL pattern B was found in both men and women, and plasma TG could have a key role in regulating the LDL peak particle size. The follow up, still ongoing, will provide useful information on the predictive role of LDL peak particle size on cardiovascular risk, at least in a low-risk population.

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“…[7][8][9][10] In fact, in 2 studies, larger LDL particles were associated with increased risk of coronary disease. 7,8 Most prospective studies, [11][12][13] but not all, 14 also found that patients with coronary disease are more likely than controls to have smaller LDL particles.…”

mentioning

confidence: 99%

“…tein (LDL) cholesterol has been associated with coronary disease in several retrospective casecontrol studies, [1][2][3][4][5][6] although other studies have not found this association. [7][8][9][10] In fact, in 2 studies, larger LDL particles were associated with increased risk of coronary disease. 7,8 Most prospective studies, [11][12][13] but not all, 14 also found that patients with coronary disease are more likely than controls to have smaller LDL particles.…”

mentioning

confidence: 99%

Low-Density Lipoprotein Size, Pravastatin Treatment, and Coronary Events

Campos¹

2001

JAMA

124

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Large LDL size was an independent predictor of coronary events in a typical population with myocardial infarction, but the adverse effect was not present among patients who were treated with pravastatin. Identifying patients on the basis of LDL size may not be useful clinically, since effective treatment for elevated LDL cholesterol concentrations also effectively treats risk associated with large LDL.

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Smaller, denser LDL particles are not a risk factor for cardiovascular disease in healthy nonagenarian women of the Cremona Population Study

Cited by 14 publications

References 29 publications

Triglyceride, small, dense low-density lipoprotein, and the atherogenic lipoprotein phenotype

Triglyceride, small, dense low-density lipoprotein, and the atherogenic lipoprotein phenotype

Low‐density‐lipoprotein peak particle size in a Mediterranean population

Low-Density Lipoprotein Size, Pravastatin Treatment, and Coronary Events

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