Small vessel disease and collaterals in ischemic stroke patients treated with thrombectomy

Forestier, Géraud; Agbonon, Rémi; Bricout, Nicolas; Benhassen, Wagih; Turc, Guillaume; Bretzner, Martin; Pasi, Marco; Benzakoun, Joseph; Seners, Pierre; Personnic, Thomas; Legrand, Laurence; Trystram, Denis; Rodriguez-Régent, Christine; Charidimou, Andreas; Rost, Natalia S.; Bracard, Serge; Clarençon, Frédéric; Nighoghossian, Norbert; Cordonnier, Charlotte; Oppenheim, Catherine; Naggara, Olivier; Hénon, Hilde; Boulouis, Grégoire

doi:10.1007/s00415-022-11099-7

Cited by 9 publications

(15 citation statements)

References 40 publications

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“…On this basis, two studies were devised to explore the linkage between the total CSVD score and the collateral status before MT with inconsistent results. 5,22 However, prognosis of the patients was not covered in that two studies. Here, preoperative collateral status was demonstrated as independent of the total CSVD score.…”

Section: Discussionmentioning

confidence: 99%

“…There are some studies which believe that lack of certain single feature can overestimate or underestimate the effect of total CSVD score, although truncated total CSVD score was analyzed in some research. 5 Fourth, the MRI used to assess CSVD were conducted before or after (within 72 h) EVT in different patients. However, chronic CSVD imaging makers were not likely to change rapidly within 72h after stroke.…”

Section: Discussionmentioning

confidence: 99%

“…Such truncated total CSVD scores were used in some previous studies because of various limitations. 5,11…”

Section: Methodsmentioning

confidence: 99%

“…Such truncated total CSVD scores were used in some previous studies because of various limitations. 5,11 Collateral status was evaluated with digital subtraction angiography (DSA) images on the basis of the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) Collateral Flow Grading System 12 : grade 0-2, poor collaterals; grade 3-4, good collaterals.…”

Section: Imaging Assessmentmentioning

confidence: 99%

“…4 Nevertheless, various CSVD features usually coexist and influence each other. In this context, combination of more than one imaging features of CSVD has been increasingly used in clinical practice, [5][6] and it is more significant to explore the association between the overall CSVD burden (measured by total CSVD score) and the therapeutic outcome of thrombectomy. 7 To this end, the current retrospective case-control study aimed at probing into the association between the overall CSVD burden and 90-day outcome of MT in 145 patients with acute ACLVOS.…”

Section: Introductionmentioning

confidence: 99%

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Overall cerebral small vessel disease burden is associated with outcome of acute ischemic stroke after mechanical thrombectomy

et al. 2022

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Objectives To investigate the association between the overall cerebral small vessel disease (CSVD) burden and the therapeutic outcome of mechanical thrombectomy (MT) in patients with acute anterior circulation large-vessel occlusion stroke. Materials and Methods Data of patients who achieved successful revascularization after MT for acute anterior circulation large-vessel occlusion stroke in the Ningbo Medical Center Lihuili Hospital between April 2017 and January 2022 were retrospectively analyzed. The overall CSVD burden was evaluated by total CSVD score based on MRI images. According to the 90-day modified Rankin Scale (mRS) score, the participants were divided into the Good outcome group (mRS score 0–2) and Poor outcome group (mRS score 3–6). Multivariate Logistic regression was applied to assess the relationship between the overal CSVD burdern and 90-day outcome. Results In total, 145 eligible patients were included and classified into the Good outcome group (n = 77, 62.3% males, mean age: 64.92 ± 13.67 years) and Poor outcome group (n = 68, 50% males, mean age: 69.76 ± 10.88 years). Symptomatic intracranial hemorrhage (OR = 2.788, 95%CI: 1.143–8.745, P = 0.048), poor preoperative collateral status (OR = 3.619, 95%CI: 1.670–7.844, P = 0.001), and high total CSVD score (score 2: OR = 3.800, 95%CI: 1.173 = 12.311, P = 0.026; score 3: OR = 7.529, 95%CI: 1.555–36.460, P = 0.012) were independently prognostic for poor 90-day outcome in patients receiving MT. Conclusion This study identified that the overall CSVD burden was independently associated with the prognosis of patients receiving MT for acute anterior circulation large-vessel occlusion stroke.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Such truncated total CSVD scores were used in some previous studies because of various limitations. 5,11…”

Section: Methodsmentioning

confidence: 99%

Section: Imaging Assessmentmentioning

confidence: 99%